From Wikipedia, the free encyclopedia
Mammalian protein found in Homo sapiens
ITGB3
Available structures
PDB Ortholog search:
PDBe
RCSB List of PDB id codes
4O02 ,
1JV2 ,
1KUP ,
1KUZ ,
1L5G ,
1M1X ,
1M8O ,
1MIZ ,
1MK7 ,
1MK9 ,
1S4X ,
1TYE ,
1U8C ,
2K9J ,
2KNC ,
2KV9 ,
2L1C ,
2L91 ,
2LJD ,
2LJE ,
2LJF ,
2MTP ,
2Q6W ,
2RMZ ,
2RN0 ,
2VC2 ,
2VDK ,
2VDL ,
2VDM ,
2VDN ,
2VDP ,
2VDQ ,
2VDR ,
3FCS ,
3FCU ,
3IJE ,
3NID ,
3NIF ,
3NIG ,
3T3M ,
3T3P ,
3ZDX ,
3ZDY ,
3ZDZ ,
3ZE0 ,
3ZE1 ,
3ZE2 ,
4CAK ,
4G1E ,
4G1M ,
4MMX ,
4MMY ,
4MMZ ,
5HDB ,
4Z7Q ,
4Z7O ,
4Z7N
Identifiers
Aliases
ITGB3 , BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT, integrin subunit beta 3, BDPLT24, GT2External IDs
OMIM :
173470
MGI :
96612
HomoloGene :
55444
GeneCards :
ITGB3
Wikidata
Integrin beta-3 (β3) or CD61 is a
protein that in humans is encoded by the ITGB3
gene .
[5] CD61 is a
cluster of differentiation found on
thrombocytes .
[6]
Structure and function
The ITGB3 protein product is the integrin beta chain beta 3.
Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface-mediated signaling.
[7]
Role in endometriosis
Defectively expressed β3 integrin subunit has been correlated with presence of
endometriosis , and has been suggested as a putative marker of this condition.
[8]
Interactions
CD61 has been shown to
interact with
PTK2 ,
[9]
[10]
ITGB3BP ,
[11]
[12]
TLN1
[13]
[14] and
CIB1 .
[15]
See also
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000259207 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000020689 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS, et al. (August 1988).
"Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa" . J Clin Invest . 81 (6): 1993–8.
doi :
10.1172/JCI113548 .
PMC
442653 .
PMID
2454952 .
^ Heemskerk, J. W. M.; Mattheij, N. J. A.; Cosemans, J. M. E. M. (2013).
"Platelet-based coagulation: different populations, different functions" (PDF) . Journal of Thrombosis and Haemostasis . 11 (1): 2–16.
doi :
10.1111/jth.12045 .
ISSN
1538-7933 .
PMID
23106920 .
S2CID
206157070 .
^
"Entrez Gene: ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)" .
^ May, K. E.; Villar, J.; Kirtley, S.; Kennedy, S. H.; Becker, C. M. (2011).
"Endometrial alterations in endometriosis: A systematic review of putative biomarkers" . Human Reproduction Update . 17 (5): 637–653.
doi :
10.1093/humupd/dmr013 .
PMID
21672902 .
^ Eliceiri, Brian P; Puente Xose S; Hood John D; Stupack Dwayne G; Schlaepfer David D; Huang Xiaozhu Z; Sheppard Dean; Cheresh David A (April 2002).
"Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling" . J. Cell Biol . 157 (1): 149–60.
doi :
10.1083/jcb.200109079 .
ISSN
0021-9525 .
PMC
2173263 .
PMID
11927607 .
^ Chung, J; Gao A G; Frazier W A (June 1997).
"Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3" . J. Biol. Chem . 272 (23): 14740–6.
doi :
10.1074/jbc.272.23.14740 .
ISSN
0021-9258 .
PMID
9169439 .
^ Fujimoto, Tetsuro-Takahiro; Katsutani Shinya; Shimomura Takeshi; Fujimura Kingo (January 2002). "Novel alternatively spliced form of beta(3)-endonexin". Thromb. Res . 105 (1): 63–70.
doi :
10.1016/S0049-3848(01)00405-4 .
ISSN
0049-3848 .
PMID
11864709 .
^ Shattil, S J; O'Toole T; Eigenthaler M; Thon V; Williams M; Babior B M; Ginsberg M H (November 1995).
"Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit" . J. Cell Biol . 131 (3): 807–16.
doi :
10.1083/jcb.131.3.807 .
ISSN
0021-9525 .
PMC
2120613 .
PMID
7593198 .
^ Patil, S; Jedsadayanmata A; Wencel-Drake J D; Wang W; Knezevic I; Lam S C (October 1999).
"Identification of a talin-binding site in the integrin beta(3) subunit distinct from the NPLY regulatory motif of post-ligand binding functions. The talin n-terminal head domain interacts with the membrane-proximal region of the beta(3) cytoplasmic tail" . J. Biol. Chem . 274 (40): 28575–83.
doi :
10.1074/jbc.274.40.28575 .
ISSN
0021-9258 .
PMID
10497223 .
^ Calderwood, David A; Yan Boxu; de Pereda Jose M; Alvarez Begoña García; Fujioka Yosuke; Liddington Robert C; Ginsberg Mark H (June 2002).
"The phosphotyrosine binding-like domain of talin activates integrins" . J. Biol. Chem . 277 (24): 21749–58.
doi :
10.1074/jbc.M111996200 .
ISSN
0021-9258 .
PMID
11932255 .
^ Naik, U P; Patel P M; Parise L V (February 1997).
"Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain" . J. Biol. Chem . 272 (8): 4651–4.
doi :
10.1074/jbc.272.8.4651 .
ISSN
0021-9258 .
PMID
9030514 .
Further reading
Bray PF (1995). "Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization". Thromb. Haemost . 72 (4): 492–502.
PMID
7878622 .
Bennett JS (2001). "Platelet-fibrinogen interactions". Ann. N. Y. Acad. Sci . 936 (1): 340–54.
Bibcode :
2001NYASA.936..340B .
doi :
10.1111/j.1749-6632.2001.tb03521.x .
PMID
11460491 .
S2CID
25431334 .
Sajid M, Stouffer GA (2002). "The role of alpha(v)beta3 integrins in vascular healing". Thromb. Haemost . 87 (2): 187–93.
doi :
10.1055/s-0037-1612971 .
PMID
11858476 .
Quinn MJ, Byzova TV, Qin J, et al. (2004).
"Integrin alphaIIbbeta3 and its antagonism" . Arterioscler. Thromb. Vasc. Biol . 23 (6): 945–52.
doi :
10.1161/01.ATV.0000066686.46338.F1 .
PMID
12637342 .
Charakida M, Tousoulis D, Stefanadis C, Toutouzas P (2003). "The impact of platelet glycoprotein IIIa and Ia polymorphisms in cardiovascular thrombotic disease". Italian Heart Journal . 4 (1): 17–22.
PMID
12690916 .
Smith FB, Connor JM, Lee AJ, et al. (2004). "Relationship of the platelet glycoprotein PlA and fibrinogen T/G+1689 polymorphisms with peripheral arterial disease and ischaemic heart disease". Thromb. Res . 112 (4): 209–16.
doi :
10.1016/j.thromres.2003.11.010 .
PMID
14987913 .
Fullard JF (2004). "The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis". Curr. Pharm. Des . 10 (14): 1567–76.
doi :
10.2174/1381612043384682 .
PMID
15134555 .
Cacciari B, Spalluto G (2005). "Non peptidic alphavbeta3 antagonists: recent developments". Curr. Med. Chem . 12 (1): 51–70.
doi :
10.2174/0929867053363522 .
PMID
15638730 .
Watson SP, Auger JM, McCarty OJ, Pearce AC (2005). "GPVI and integrin alphaIIb beta3 signaling in platelets". J. Thromb. Haemost . 3 (8): 1752–62.
doi :
10.1111/j.1538-7836.2005.01429.x .
PMID
16102042 .
S2CID
42666713 .
Bennett JS (2006).
"Structure and function of the platelet integrin alphaIIbbeta3" . J. Clin. Invest . 115 (12): 3363–9.
doi :
10.1172/JCI26989 .
PMC
1297263 .
PMID
16322781 .
External links
PDB gallery
1jv2 : CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHAVBETA3
1l5g : CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN AVB3 IN COMPLEX WITH AN ARG-GLY-ASP LIGAND
1m1x : CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHA VBETA3 BOUND TO MN2+
1m8o : Platelet integrin alfaIIb-beta3 cytoplasmic domain
1txv :
1ty3 :
1ty5 :
1ty6 :
1ty7 :
1tye : Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the platelet receptor for fibrinogen
1u8c : A novel adaptation of the integrin PSI domain revealed from its crystal structure
1–50 51–100 101–150 151–200 201–250 251–300 301–350
Alpha Beta Dimers
Cytoadhesin receptor: Fibrinogen receptor: Fibronectin receptor: Leukocyte-adhesion receptor: Very late antigen receptor: Vitronectin receptor: