From Wikipedia, the free encyclopedia
Chlorohydroxyphenylglycine
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Names
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IUPAC name
Amino(2-chloro-5-hydroxyphenyl)acetic acid
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Identifiers
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Abbreviations
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CHPG
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ChemSpider
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ECHA InfoCard
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100.162.133
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UNII
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InChI=1S/C8H8ClNO3/c9-6-2-1-4(11)3-5(6)7(10)8(12)13/h1-3,7,11H,10H2,(H,12,13) Key: UNIDAFCQFPGYJJ-UHFFFAOYSA-N InChI=1/C8H8ClNO3/c9-6-2-1-4(11)3-5(6)7(10)8(12)13/h1-3,7,11H,10H2,(H,12,13) Key: UNIDAFCQFPGYJJ-UHFFFAOYAM
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Properties
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C8H6ClNO3
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Molar mass
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199.59 g·mol−1
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Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
2-Chloro-5-hydroxyphenylglycine or CHPG is an agonist of the
metabotropic glutamate receptors, specific for
mGluR5.
[1]
It is capable of directly potentiating the depolarization of
hippocampal CA1 neurons induced through
NMDA administration.
[2]
References
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Group I |
mGluR1Tooltip Metabotropic glutamate receptor 1 | |
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mGluR5Tooltip Metabotropic glutamate receptor 5 | |
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Group II |
mGluR2Tooltip Metabotropic glutamate receptor 2 | |
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mGluR3Tooltip Metabotropic glutamate receptor 3 | |
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Group III |
mGluR4Tooltip Metabotropic glutamate receptor 4 | |
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mGluR6Tooltip Metabotropic glutamate receptor 6 | |
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mGluR7Tooltip Metabotropic glutamate receptor 7 | |
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mGluR8Tooltip Metabotropic glutamate receptor 8 | |
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