From Wikipedia, the free encyclopedia
Chemical compound
LY-344545
(αS)-α-Amino-α-[(1R,2R)-2-carboxycyclopropyl]-9H-xanthene-9-propanoic acid
CAS Number
PubChem
CID
ChemSpider
UNII
Formula C 20 H 19 N O 5
Molar mass 353.374 g·mol−1 3D model (
JSmol )
c1ccc2c(c1)C(c3ccccc3O2)C[C@]([C@@H]4C[C@H]4C(=O)O)(C(=O)O)N
InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20+/m1/s1
Key:VLZBRVJVCCNPRJ-RCDCFZSISA-N
(verify)
LY-344,545 is a research drug developed by the pharmaceutical company
Eli Lilly , which acts as an
antagonist for the
metabotropic glutamate receptor subtype
mGluR5 . It is an
epimer of another metabotropic glutamate receptor antagonist, the
mGluR2/3 -selective
LY-341,495 .
[1]
[2]
References
^ Ornstein PL, Bleisch TJ, Arnold MB, Kennedy JH, Wright RA, Johnson BG, et al. (January 1998). "2-substituted (2SR )-2-amino-2-((1SR ,2SR )-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioavailability". Journal of Medicinal Chemistry . 41 (3): 358–78.
doi :
10.1021/jm970498o .
PMID
9464367 .
^ Doherty AJ, Palmer MJ, Bortolotto ZA, Hargreaves A, Kingston AE, Ornstein PL, et al. (September 2000).
"A novel, competitive mGlu(5) receptor antagonist (LY344545) blocks DHPG-induced potentiation of NMDA responses but not the induction of LTP in rat hippocampal slices" . British Journal of Pharmacology . 131 (2): 239–44.
doi :
10.1038/sj.bjp.0703574 .
PMC
1572327 .
PMID
10991916 .
Group I
mGluR1 Tooltip Metabotropic glutamate receptor 1
mGluR5 Tooltip Metabotropic glutamate receptor 5
Group II
mGluR2 Tooltip Metabotropic glutamate receptor 2
mGluR3 Tooltip Metabotropic glutamate receptor 3
Group III
mGluR4 Tooltip Metabotropic glutamate receptor 4
mGluR6 Tooltip Metabotropic glutamate receptor 6
mGluR7 Tooltip Metabotropic glutamate receptor 7
mGluR8 Tooltip Metabotropic glutamate receptor 8