From Wikipedia, the free encyclopedia
Chemical compound
Ro67-4853 is a drug used in scientific research, which acts as a selective
positive allosteric modulator for the
metabotropic glutamate receptor subtype
mGluR1.
[1]
[2]
[3] It was derived by modification of the simpler compound
Ro01-6128, and has itself subsequently been used as a
lead compound to develop a range of potent and selective mGluR1 positive modulators.
[4]
[5]
See also
C19H19NO4
References
-
^ Knoflach F, Mutel V, Jolidon S, Kew JN, Malherbe P, Vieira E, Wichmann J, Kemp JA (November 2001).
"Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site". Proceedings of the National Academy of Sciences of the United States of America. 98 (23): 13402–7.
Bibcode:
2001PNAS...9813402K.
doi:
10.1073/pnas.231358298.
PMC
60883.
PMID
11606768.
-
^ Hemstapat K, de Paulis T, Chen Y, Brady AE, Grover VK, Alagille D, Tamagnan GD, Conn PJ (August 2006).
"A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators" (PDF). Molecular Pharmacology. 70 (2): 616–626.
doi:
10.1124/mol.105.021857.
PMID
16645124.
S2CID
2719603. Archived from
the original (PDF) on 2019-02-22.
-
^ Sheffler DJ, Conn PJ (September 2008).
"Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells". Neuropharmacology. 55 (4): 419–27.
doi:
10.1016/j.neuropharm.2008.06.047.
PMC
2600811.
PMID
18625258.
-
^ Vieira E, Huwyler J, Jolidon S, Knoflach F, Mutel V, Wichmann J (October 2005). "9H-Xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl- and (2H-tetrazol-5-yl)-amides as potent, orally available mGlu1 receptor enhancers". Bioorganic & Medicinal Chemistry Letters. 15 (20): 4628–31.
doi:
10.1016/j.bmcl.2005.05.135.
PMID
16099654.
-
^ Vieira E, Huwyler J, Jolidon S, Knoflach F, Mutel V, Wichmann J (March 2009). "Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers". Bioorganic & Medicinal Chemistry Letters. 19 (6): 1666–9.
doi:
10.1016/j.bmcl.2009.01.108.
PMID
19233648.
|
---|
Group I |
mGluR1Tooltip Metabotropic glutamate receptor 1 | |
---|
mGluR5Tooltip Metabotropic glutamate receptor 5 | |
---|
|
---|
Group II |
mGluR2Tooltip Metabotropic glutamate receptor 2 | |
---|
mGluR3Tooltip Metabotropic glutamate receptor 3 | |
---|
|
---|
Group III |
mGluR4Tooltip Metabotropic glutamate receptor 4 | |
---|
mGluR6Tooltip Metabotropic glutamate receptor 6 | |
---|
mGluR7Tooltip Metabotropic glutamate receptor 7 | |
---|
mGluR8Tooltip Metabotropic glutamate receptor 8 | |
---|
|
---|
|