From Wikipedia, the free encyclopedia
Chemical compound
RU-58642 is a
nonsteroidal antiandrogen (NSAA) derived from
nilutamide with very high
affinity and
selectivity for the
androgen receptor (AR), which made it among the most
potent and
efficacious antiandrogens known at the time of its discovery.
[1] It was investigated for
topical application for the treatment of
androgenetic alopecia (male-pattern baldness), but development did not proceed past initial trial stages, and it is now only used for
scientific research into the AR.
[2]
[3]
See also
References
^ Battmann T, Branche C, Bouchoux F, Cerede E, Philibert D, Goubet F, Teutsch G, Gaillard-Kelly M (January 1998). "Pharmacological profile of RU 58642, a potent systemic antiandrogen for the treatment of androgen-dependent disorders". The Journal of Steroid Biochemistry and Molecular Biology . 64 (1–2): 103–11.
doi :
10.1016/S0960-0760(97)00151-9 .
PMID
9569015 .
S2CID
290926 .
^ Sims NA, Clément-Lacroix P, Minet D, Fraslon-Vanhulle C, Gaillard-Kelly M, Resche-Rigon M, Baron R (May 2003).
"A functional androgen receptor is not sufficient to allow estradiol to protect bone after gonadectomy in estradiol receptor-deficient mice" . The Journal of Clinical Investigation . 111 (9): 1319–27.
doi :
10.1172/JCI17246 .
PMC
154447 .
PMID
12727923 .
^ Windahl SH, Galien R, Chiusaroli R, Clément-Lacroix P, Morvan F, Lepescheux L, Nique F, Horne WC, Resche-Rigon M, Baron R (September 2006).
"Bone protection by estrens occurs through non-tissue-selective activation of the androgen receptor" . The Journal of Clinical Investigation . 116 (9): 2500–9.
doi :
10.1172/JCI28809 .
PMC
1555662 .
PMID
16955145 .
AR Tooltip Androgen receptor
Agonists
SARMs Tooltip Selective androgen receptor modulator Antagonists
GPRC6A