From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Myosin-Ie (Myo1e) is a
protein that in humans is encoded by the MYO1E
gene .
[5]
[6]
Myosin-Ie is a long tailed myosin. It contains an N-terminal motor domain, an IQ motif, a TH1 domain containing a
plecstrin homology (PH) domain, a proline rich TH2 domain, and an
SH3 domain .
[7]
The MYO1E gene was included in several genetic signatures for cancer prognosis.
[8]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000157483 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000032220 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, et al. (September 1996).
"Mapping of unconventional myosins in mouse and human" . Genomics . 36 (3): 431–439.
doi :
10.1006/geno.1996.0488 .
PMID
8884266 .
^
"Entrez Gene: MYO1E myosin IE" .
^ McConnell RE, Tyska MJ (July 2010).
"Leveraging the membrane - cytoskeleton interface with myosin-1" . Trends in Cell Biology . 20 (7): 418–426.
doi :
10.1016/j.tcb.2010.04.004 .
PMC
2897960 .
PMID
20471271 .
^ Chicco D, Alameer A, Rahmati S, Jurman G (November 2022).
"Towards a potential pan-cancer prognostic signature for gene expression based on probesets and ensemble machine learning" . BioData Mining . 15 (1): 28.
doi :
10.1186/s13040-022-00312-y .
eISSN
1756-0381 .
PMC
9632055 .
PMID
36329531 .
Further reading
Krendel M, Osterweil EK, Mooseker MS (February 2007).
"Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis" . FEBS Letters . 581 (4): 644–650.
doi :
10.1016/j.febslet.2007.01.021 .
PMC
1861834 .
PMID
17257598 .
El Mezgueldi M, Tang N, Rosenfeld SS, Ostap EM (June 2002).
"The kinetic mechanism of Myo1e (human myosin-IC)" . The Journal of Biological Chemistry . 277 (24): 21514–21521.
doi :
10.1074/jbc.M200713200 .
PMID
11940582 .
Skowron JF, Bement WM, Mooseker MS (1999). "Human brush border myosin-I and myosin-Ic expression in human intestine and Caco-2BBe cells". Cell Motility and the Cytoskeleton . 41 (4): 308–324.
doi :
10.1002/(SICI)1097-0169(1998)41:4<308::AID-CM4>3.0.CO;2-J .
PMID
9858156 .
Robertson H, Langdon WY, Thien CB, Bowtell DD (November 1997). "A c-Cbl yeast two hybrid screen reveals interactions with 14-3-3 isoforms and cytoskeletal components". Biochemical and Biophysical Research Communications . 240 (1): 46–50.
doi :
10.1006/bbrc.1997.7608 .
PMID
9367879 .
Bement WM, Hasson T, Wirth JA, Cheney RE, Mooseker MS (July 1994).
"Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types" . Proceedings of the National Academy of Sciences of the United States of America . 91 (14): 6549–6553.
Bibcode :
1994PNAS...91.6549B .
doi :
10.1073/pnas.91.14.6549 .
PMC
44240 .
PMID
8022818 .
Bement WM, Wirth JA, Mooseker MS (October 1994).
"Cloning and mRNA expression of human unconventional myosin-IC. A homologue of amoeboid myosins-I with a single IQ motif and an SH3 domain" . Journal of Molecular Biology . 243 (2): 356–363.
doi :
10.1006/jmbi.1994.1662 .
PMID
7932763 .
External links
Overview of all the structural information available in the
PDB for
UniProt :
E9Q634 (Mouse Unconventional myosin-Ie) at the
PDBe-KB .