Myosin-Ic is a
protein that in humans is encoded by the MYO1Cgene.[5][6]
This gene encodes a member of the unconventional
myosin protein family, which are
actin-based molecular motors. The protein is found in the
cytoplasm, and one
isoform with a unique
N-terminus is also found in the
nucleus. The nuclear isoform associates with
RNA polymerase I and
II and functions in
transcription initiation. The mouse ortholog of this protein also functions in intracellular
vesicle transport to the
plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on
chromosome 19.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Crozet F, el Amraoui A, Blanchard S, Lenoir M, Ripoll C, Vago P, Hamel C, Fizames C, Levi-Acobas F, Depetris D, Mattei MG, Weil D, Pujol R, Petit C (Apr 1997). "Cloning of the genes encoding two murine and human cochlear unconventional type I myosins". Genomics. 40 (2): 332–41.
doi:
10.1006/geno.1996.4526.
PMID9119401.
Ruppert C, Godel J, Müller RT, et al. (1997). "Localization of the rat myosin I molecules myr 1 and myr 2 and in vivo targeting of their tail domains". J. Cell Sci. 108 (12): 3775–86.
doi:
10.1242/jcs.108.12.3775.
PMID8719884.
Philimonenko VV, Zhao J, Iben S, et al. (2005). "Nuclear actin and myosin I are required for RNA polymerase I transcription". Nat. Cell Biol. 6 (12): 1165–72.
doi:
10.1038/ncb1190.
PMID15558034.
S2CID6633625.
Kyselá K, Philimonenko AA, Philimonenko VV, et al. (2005). "Nuclear distribution of actin and myosin I depends on transcriptional activity of the cell". Histochem. Cell Biol. 124 (5): 347–58.
doi:
10.1007/s00418-005-0042-8.
PMID16133118.
S2CID28731167.
Kahle M, Pridalová J, Spacek M, et al. (2007). "Nuclear myosin is ubiquitously expressed and evolutionary conserved in vertebrates". Histochem. Cell Biol. 127 (2): 139–48.
doi:
10.1007/s00418-006-0231-0.
PMID16957816.
S2CID23325557.
Hofmann WA, Vargas GM, Ramchandran R, et al. (2006). "Nuclear myosin I is necessary for the formation of the first phosphodiester bond during transcription initiation by RNA polymerase II". J. Cell. Biochem. 99 (4): 1001–9.
doi:
10.1002/jcb.21035.
PMID16960872.
S2CID39237955.