From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Kinesin family member 5B (KIF5B) is a
protein that in humans is encoded by the KIF5B
gene .
[5]
[6] It is part of the
kinesin family of
motor proteins .
Interactions
KIF5B has been shown to
interact with:
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000170759 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000006740 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Navone F, Niclas J, Hom-Booher N, Sparks L, Bernstein HD, McCaffrey G, Vale RD (Jun 1992).
"Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells" . The Journal of Cell Biology . 117 (6): 1263–75.
doi :
10.1083/jcb.117.6.1263 .
PMC
2289507 .
PMID
1607388 .
^
"Entrez Gene: KIF5B kinesin family member 5B" .
^
a
b
c Diefenbach RJ, Diefenbach E, Douglas MW, Cunningham AL (Dec 2002). "The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23". Biochemistry . 41 (50): 14906–15.
doi :
10.1021/bi026417u .
PMID
12475239 .
^
a
b Rahman A, Friedman DS, Goldstein LS (Jun 1998).
"Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins" . The Journal of Biological Chemistry . 273 (25): 15395–403.
doi :
10.1074/jbc.273.25.15395 .
PMID
9624122 .
^
a
b Rahman A, Kamal A, Roberts EA, Goldstein LS (Sep 1999).
"Defective kinesin heavy chain behavior in mouse kinesin light chain mutants" . The Journal of Cell Biology . 146 (6): 1277–88.
doi :
10.1083/jcb.146.6.1277 .
PMC
2156125 .
PMID
10491391 .
^ Ichimura T, Wakamiya-Tsuruta A, Itagaki C, Taoka M, Hayano T, Natsume T, Isobe T (Apr 2002). "Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein". Biochemistry . 41 (17): 5566–72.
doi :
10.1021/bi015946f .
PMID
11969417 .
Further reading
Niclas J, Navone F, Hom-Booher N, Vale RD (May 1994). "Cloning and localization of a conventional kinesin motor expressed exclusively in neurons". Neuron . 12 (5): 1059–72.
doi :
10.1016/0896-6273(94)90314-X .
PMID
7514426 .
S2CID
32927183 .
Kull FJ, Sablin EP, Lau R, Fletterick RJ, Vale RD (Apr 1996).
"Crystal structure of the kinesin motor domain reveals a structural similarity to myosin" . Nature . 380 (6574): 550–5.
Bibcode :
1996Natur.380..550J .
doi :
10.1038/380550a0 .
PMC
2851642 .
PMID
8606779 .
Rahman A, Friedman DS, Goldstein LS (Jun 1998).
"Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins" . The Journal of Biological Chemistry . 273 (25): 15395–403.
doi :
10.1074/jbc.273.25.15395 .
PMID
9624122 .
Tanaka Y, Kanai Y, Okada Y, Nonaka S, Takeda S, Harada A, Hirokawa N (Jun 1998).
"Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria" . Cell . 93 (7): 1147–58.
doi :
10.1016/S0092-8674(00)81459-2 .
PMID
9657148 .
S2CID
17524297 .
Rahman A, Kamal A, Roberts EA, Goldstein LS (Sep 1999).
"Defective kinesin heavy chain behavior in mouse kinesin light chain mutants" . The Journal of Cell Biology . 146 (6): 1277–88.
doi :
10.1083/jcb.146.6.1277 .
PMC
2156125 .
PMID
10491391 .
Ong LL, Lim AP, Er CP, Kuznetsov SA, Yu H (Oct 2000).
"Kinectin-kinesin binding domains and their effects on organelle motility" . The Journal of Biological Chemistry . 275 (42): 32854–60.
doi :
10.1074/jbc.M005650200 .
PMID
10913441 .
Kanai Y, Okada Y, Tanaka Y, Harada A, Terada S, Hirokawa N (Sep 2000).
"KIF5C, a novel neuronal kinesin enriched in motor neurons" . The Journal of Neuroscience . 20 (17): 6374–84.
doi :
10.1523/JNEUROSCI.20-17-06374.2000 .
PMC
6772948 .
PMID
10964943 .
Setou M, Seog DH, Tanaka Y, Kanai Y, Takei Y, Kawagishi M, Hirokawa N (May 2002). "Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendrites". Nature . 417 (6884): 83–7.
Bibcode :
2002Natur.417...83S .
doi :
10.1038/nature743 .
PMID
11986669 .
S2CID
4400494 .
Hakimi MA, Speicher DW, Shiekhattar R (Oct 2002).
"The motor protein kinesin-1 links neurofibromin and merlin in a common cellular pathway of neurofibromatosis" . The Journal of Biological Chemistry . 277 (40): 36909–12.
doi :
10.1074/jbc.C200434200 .
PMID
12191989 .
Diefenbach RJ, Diefenbach E, Douglas MW, Cunningham AL (Dec 2002). "The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23". Biochemistry . 41 (50): 14906–15.
doi :
10.1021/bi026417u .
PMID
12475239 .
Macioce P, Gambara G, Bernassola M, Gaddini L, Torreri P, Macchia G, Ramoni C, Ceccarini M, Petrucci TC (Dec 2003).
"Beta-dystrobrevin interacts directly with kinesin heavy chain in brain" . Journal of Cell Science . 116 (Pt 23): 4847–56.
doi :
10.1242/jcs.00805 .
PMID
14600269 .
Diefenbach RJ, Diefenbach E, Douglas MW, Cunningham AL (Jul 2004). "The ribosome receptor, p180, interacts with kinesin heavy chain, KIF5B". Biochemical and Biophysical Research Communications . 319 (3): 987–92.
doi :
10.1016/j.bbrc.2004.05.069 .
PMID
15184079 .
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004).
"Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization" . Current Biology . 14 (16): 1436–50.
Bibcode :
2004CBio...14.1436J .
doi :
10.1016/j.cub.2004.07.051 .
PMID
15324660 .
S2CID
2371325 .
Su Q, Cai Q, Gerwin C, Smith CL, Sheng ZH (Oct 2004). "Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons". Nature Cell Biology . 6 (10): 941–53.
doi :
10.1038/ncb1169 .
PMID
15459722 .
S2CID
6875457 .
Brickley K, Smith MJ, Beck M, Stephenson FA (Apr 2005).
"GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin" . The Journal of Biological Chemistry . 280 (15): 14723–32.
doi :
10.1074/jbc.M409095200 .
PMID
15644324 .
Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (Jun 2005).
"Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer" . Molecular & Cellular Proteomics . 4 (6): 785–95.
doi :
10.1074/mcp.M500021-MCP200 .
PMID
15778465 .
External links
Overview of all the structural information available in the
PDB for
UniProt :
P33176 (Kinesin-1 heavy chain) at the
PDBe-KB .