Keratin, type II cytoskeletal 78 is a
protein that in humans is encoded by the KRT78gene.[5][6]
This gene is a member of the type II
keratin gene family and encodes a
protein with an intermediate filament domain. Keratins are the major
structural proteins in
epithelial cells, forming a
cytoplasmic network of 10 to 12 nm wide intermediate filaments and creating a scaffold that gives cells the ability to withstand
mechanical and non-mechanical stresses. The genes of the type II keratin family are located as a gene cluster at 12p13.13. Four
pseudogenes of this gene family have been identified.[6]
Hesse M, Magin TM, Weber K (2002). "Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18". J. Cell Sci. 114 (Pt 14): 2569–75.
doi:
10.1242/jcs.114.14.2569.
PMID11683385.