From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
FLNB
Available structures
PDB Ortholog search:
PDBe
RCSB List of PDB id codes
2DI8 ,
2DI9 ,
2DIA ,
2DIB ,
2DIC ,
2DJ4 ,
2DLG ,
2DMB ,
2DMC ,
2E9I ,
2E9J ,
2EE6 ,
2EE9 ,
2EEA ,
2EEB ,
2EEC ,
2EED ,
2WA5 ,
2WA6 ,
2WA7 ,
3FER ,
4B7L
Identifiers
Aliases
FLNB , ABP-278, ABP-280, AOI, FH1, FLN-B, FLN1L, LRS1, SCT, TABP, TAP, filamin BExternal IDs
OMIM :
603381
MGI :
2446089
HomoloGene :
37480
GeneCards :
FLNB
Wikidata
Filamin B, beta (FLNB ), also known as Filamin B, beta (truncated actin binding protein 278 homolog) , is a
cytoplasmic
protein which in humans is encoded by the FLNB
gene .
FLNB regulates intracellular communication and signalling by cross-linking the protein
actin to allow direct communication between the
cell membrane and
cytoskeletal network , to control and guide proper skeletal development.
[5]
Mutations in the FLNB gene are involved in several
lethal bone dysplasias , including
boomerang dysplasia and
atelosteogenesis type I .
[6]
[7]
[8]
Interactions
FLNB has been shown to
interact with
GP1BA ,
[9]
Filamin ,
[10]
FBLIM1 ,
[11]
PSEN1 ,
[12]
CD29
[13] and
PSEN2 .
[12]
See also
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000136068 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000025278 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Lu J, Lian G, Lenkinski R, De Grand A, Vaid RR, Bryce T, Stasenko M, Boskey A, Walsh C, Sheen V (2007).
"Filamin B mutations cause chondrocyte defects in skeletal development" . Hum Mol Genet . 16 (14): 1661–1675.
doi :
10.1093/hmg/ddm114 .
PMID
17510210 .
^ Bicknell LS, Morgan T, Bonife L, Wessels MW, Bialer MG, Willems PJ, Cohen DH, Krakow D, Robertson SP (2005).
"Mutations in FLNB cause boomerang dysplasia" . Am J Med Genet . 42 (7): e43.
doi :
10.1136/jmg.2004.029967 .
PMC
1736093 .
PMID
15994868 .
^ Greally MT; Jewett T; Smith WL Jr.; Penick GD; Williamson RA (1993). "Lethal bone dysplasia in a fetus with manifestations of Atelosteogenesis type I and Boomerang dysplasia". Am J Med Genet . 47 (4): 1086–1091.
doi :
10.1002/ajmg.1320470731 .
PMID
8291529 .
^ Nishimura G, Horiuchi T, Kim OH, Sasamoto Y (1997). "Atypical skeletal changes in otopalatodigital syndrome type II: phenotypic overlap among otopalatodigital syndrome type II, boomerang dysplasia, atelosteogenesis type I and type III, and lethal male phenotype of Melnick-Needles syndrome". Am J Med Genet . 73 (2): 132–138.
doi :
10.1002/(SICI)1096-8628(19971212)73:2<132::AID-AJMG6>3.0.CO;2-W .
PMID
9409862 .
^ Takafuta, T; Wu G; Murphy G F; Shapiro S S (Jul 1998).
"Human beta-filamin is a new protein that interacts with the cytoplasmic tail of glycoprotein Ibalpha" . J. Biol. Chem . 273 (28). UNITED STATES: 17531–8.
doi :
10.1074/jbc.273.28.17531 .
ISSN
0021-9258 .
PMID
9651345 .
^ Sheen, Volney L; Feng Yuanyi; Graham Donna; Takafuta Toshiro; Shapiro Sandor S; Walsh Christopher A (Nov 2002).
"Filamin A and Filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact" . Hum. Mol. Genet . 11 (23). England: 2845–54.
doi :
10.1093/hmg/11.23.2845 .
ISSN
0964-6906 .
PMID
12393796 .
^ Takafuta, Toshiro; Saeki Mari; Fujimoto Tetsuro-Takahiro; Fujimura Kingo; Shapiro Sandor S (Apr 2003).
"A new member of the LIM protein family binds to filamin B and localizes at stress fibers" . J. Biol. Chem . 278 (14). United States: 12175–81.
doi :
10.1074/jbc.M209339200 .
ISSN
0021-9258 .
PMID
12496242 .
^
a
b Zhang, W; Han S W; McKeel D W; Goate A; Wu J Y (Feb 1998).
"Interaction of presenilins with the filamin family of actin-binding proteins" . J. Neurosci . 18 (3). UNITED STATES: 914–22.
doi :
10.1523/JNEUROSCI.18-03-00914.1998 .
ISSN
0270-6474 .
PMC
2042137 .
PMID
9437013 .
^ van der Flier, Arjan; Kuikman Ingrid; Kramer Duco; Geerts Dirk; Kreft Maaike; Takafuta Toshiro; Shapiro Sandor S; Sonnenberg Arnoud (Jan 2002).
"Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits" . J. Cell Biol . 156 (2). United States: 361–76.
doi :
10.1083/jcb.200103037 .
ISSN
0021-9525 .
PMC
2199218 .
PMID
11807098 .
External links
Further reading
Stossel TP, Condeelis J, Cooley L, et al. (2001). "Filamins as integrators of cell mechanics and signalling". Nat. Rev. Mol. Cell Biol . 2 (2): 138–45.
doi :
10.1038/35052082 .
PMID
11252955 .
S2CID
5203942 .
van der Flier A, Sonnenberg A (2001).
"Structural and functional aspects of filamins" . Biochim. Biophys. Acta . 1538 (2–3): 99–117.
doi :
10.1016/S0167-4889(01)00072-6 .
PMID
11336782 .
Vujic M, Hallstensson K, Wahlström J, et al. (1995).
"Localization of a gene for autosomal dominant Larsen syndrome to chromosome region 3p21.1-14.1 in the proximity of, but distinct from, the COL7A1 locus" . Am. J. Hum. Genet . 57 (5): 1104–13.
PMC
1801374 .
PMID
7485161 .
Leedman PJ, Faulkner-Jones B, Cram DS, et al. (1993).
"Cloning from the thyroid of a protein related to actin binding protein that is recognized by Graves disease immunoglobulins" . Proc. Natl. Acad. Sci. U.S.A . 90 (13): 5994–8.
Bibcode :
1993PNAS...90.5994L .
doi :
10.1073/pnas.90.13.5994 .
PMC
46853 .
PMID
8327473 .
Zhang W, Han SW, McKeel DW, et al. (1998).
"Interaction of presenilins with the filamin family of actin-binding proteins" . J. Neurosci . 18 (3): 914–22.
doi :
10.1523/JNEUROSCI.18-03-00914.1998 .
PMC
2042137 .
PMID
9437013 .
Takafuta T, Wu G, Murphy GF, Shapiro SS (1998).
"Human beta-filamin is a new protein that interacts with the cytoplasmic tail of glycoprotein Ibalpha" . J. Biol. Chem . 273 (28): 17531–8.
doi :
10.1074/jbc.273.28.17531 .
PMID
9651345 .
Xu W, Xie Z, Chung DW, Davie EW (1998). "A novel human actin-binding protein homologue that binds to platelet glycoprotein Ibalpha". Blood . 92 (4): 1268–76.
doi :
10.1182/blood.V92.4.1268 .
PMID
9694715 .
Bröcker F, Bardenheuer W, Vieten L, et al. (1999). "Assignment of human filamin gene FLNB to human chromosome band 3p14.3 and identification of YACs containing the complete FLNB transcribed region". Cytogenet. Cell Genet . 85 (3–4): 267–8.
doi :
10.1159/000015309 .
PMID
10449914 .
S2CID
36854151 .
Ikeda K, Takahashi Y, Katagiri S (2000).
"Effect of medium change on the development of in vitro matured and fertilized bovine oocytes cultured in medium containing amino acids" . J. Vet. Med. Sci . 62 (1): 121–3.
doi :
10.1292/jvms.62.121 .
PMID
10676904 .
Chakarova C, Wehnert MS, Uhl K, et al. (2001). "Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family". Hum. Genet . 107 (6): 597–611.
doi :
10.1007/s004390000414 .
PMID
11153914 .
S2CID
39416345 .
Dyson JM, O'Malley CJ, Becanovic J, et al. (2002).
"The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin" . J. Cell Biol . 155 (6): 1065–79.
doi :
10.1083/jcb.200104005 .
PMC
2150887 .
PMID
11739414 .
van der Flier A, Kuikman I, Kramer D, et al. (2002).
"Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits" . J. Cell Biol . 156 (2): 361–76.
doi :
10.1083/jcb.200103037 .
PMC
2199218 .
PMID
11807098 .
Donaldson JC, Dise RS, Ritchie MD, Hanks SK (2002).
"Nephrocystin-conserved domains involved in targeting to epithelial cell-cell junctions, interaction with filamins, and establishing cell polarity" . J. Biol. Chem . 277 (32): 29028–35.
doi :
10.1074/jbc.M111697200 .
PMID
12006559 .
Shoeman RL, Hartig R, Hauses C, Traub P (2003). "Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease". Cell Biol. Int . 26 (6): 529–39.
doi :
10.1006/cbir.2002.0895 .
PMID
12119179 .
S2CID
39778155 .
Sheen VL, Feng Y, Graham D, et al. (2003).
"Filamin A and Filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact" . Hum. Mol. Genet . 11 (23): 2845–54.
doi :
10.1093/hmg/11.23.2845 .
PMID
12393796 .
Takafuta T, Saeki M, Fujimoto TT, et al. (2003).
"A new member of the LIM protein family binds to filamin B and localizes at stress fibers" . J. Biol. Chem . 278 (14): 12175–81.
doi :
10.1074/jbc.M209339200 .
PMID
12496242 .
Himmel M, Van Der Ven PF, Stöcklein W, Fürst DO (2003). "The limits of promiscuity: isoform-specific dimerization of filamins". Biochemistry . 42 (2): 430–9.
doi :
10.1021/bi026501+ .
PMID
12525170 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
PDB gallery
2di8 : Solution structure of the 19th filamin domain from human Filamin-B
2di9 : Solution structure of the 9th filamin domain from human Filamin-B
2dia : Solution structure of the 10th filamin domain from human Filamin-B
2dib : Solution structure of the 11th filamin domain from human Filamin-B
2dic : Solution structure of the 12th filamin domain from human Filamin-B
2dj4 : Solution structure of the 13th filamin domain from human Filamin-B
2dlg : Solution structure of the 20th Filamin domain from human Filamin-B
2dmb : Solution structure of the 15th Filamin domain from human Filamin-B
2dmc : Solution structure of the 18th Filamin domain from human Filamin-B