From Wikipedia, the free encyclopedia
Microtubule minus-end binding human protein
Calmodulin-regulated spectrin-associated protein 1 (CAMSAP1) is a human
protein encoded by the
gene CAMSAP1. Like other CAMSAP-family proteins, it is a
microtubule minus-end anchor, and binds microtubules through its
CKK domain .
[4]
Clinical significance
CAMSAP1 is vital for
neuron polarisation, and so mice that lack CAMSAP1 die of
epileptic seizures .
[5]
See also
References
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000026933 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Baines, A. J.; Bignone, P. A.; King, M. D.A.; Maggs, A. M.; Bennett, P. M.; Pinder, J. C.; Phillips, G. W. (2009-09-01).
"The CKK Domain (DUF1781) Binds Microtubules and Defines the CAMSAP/ssp4 Family of Animal Proteins" . Molecular Biology and Evolution . 26 (9): 2005–2014.
doi :
10.1093/molbev/msp115 .
ISSN
0737-4038 .
PMID
19508979 .
^ Zhou Z, Xu H, Li Y, Yang M, Zhang R, Shiraishi A, et al. (September 2020).
"CAMSAP1 breaks the homeostatic microtubule network to instruct neuronal polarity" . Proceedings of the National Academy of Sciences of the United States of America . 117 (36): 22193–22203.
Bibcode :
2020PNAS..11722193Z .
doi :
10.1073/pnas.1913177117 .
PMC
7486724 .
PMID
32839317 .