From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Kinesin-like protein KIF2C is a
protein that in humans is encoded by the KIF2C
gene .
[5]
[6]
The protein encoded by this gene is a member of
kinesin -like protein family, and contains common ATPase site structures such as the P-loop, Switch 1, and Switch 2.
[7] Most proteins of this family are
microtubule -dependent
molecular motors that transport
organelles within cells and move
chromosomes during
cell division . This protein acts to regulate microtubule dynamics in cells and is important for
anaphase
chromosome segregation and may be required to coordinate the onset of sister
centromere separation.
[6]
A ribbon and surface diagram of the KIF2C motor domain.
[8] The kinesin structure is pseudo-colored to highlight the ATPase site with a bound nucleotide. The figure then presents KIF2C binding to the tubulin dimer and finally visualizes a KIF2C motor head in the context of the microtubule filament.
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000142945 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000028678 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Kim IG, Jun DY, Sohn U, Kim YH (December 1997).
"Cloning and expression of human mitotic centromere-associated kinesin gene" . Biochimica et Biophysica Acta . 1359 (3): 181–186.
doi :
10.1016/s0167-4889(97)00103-1 .
PMID
9434124 .
^
a
b
"Entrez Gene: KIF2C kinesin family member 2C" .
^ Wang W, Cantos-Fernandes S, Lv Y, Kuerban H, Ahmad S, Wang C, Gigant B (July 2017).
"Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin" . Nature Communications . 8 (1): 70.
doi :
10.1038/s41467-017-00091-9 .
PMC
5503940 .
PMID
28694425 .
^
"RCSB PDB - 3EDL: Kinesin13-Microtubule Ring complex" . RCSB Protein Data Bank . Retrieved 2024-04-21 .
Further reading
Miki H, Setou M, Kaneshiro K, Hirokawa N (June 2001).
"All kinesin superfamily protein, KIF, genes in mouse and human" . Proceedings of the National Academy of Sciences of the United States of America . 98 (13): 7004–7011.
Bibcode :
2001PNAS...98.7004M .
doi :
10.1073/pnas.111145398 .
PMC
34614 .
PMID
11416179 .
Maney T, Hunter AW, Wagenbach M, Wordeman L (August 1998).
"Mitotic centromere-associated kinesin is important for anaphase chromosome segregation" . The Journal of Cell Biology . 142 (3): 787–801.
doi :
10.1083/jcb.142.3.787 .
PMC
2148171 .
PMID
9700166 .
Wordeman L, Wagenbach M, Maney T (2000). "Mutations in the ATP-binding domain affect the subcellular distribution of mitotic centromere-associated kinesin (MCAK)". Cell Biology International . 23 (4): 275–286.
doi :
10.1006/cbir.1999.0359 .
PMID
10600236 .
S2CID
29403722 .
Sugata N, Li S, Earnshaw WC, Yen TJ, Yoda K, Masumoto H, et al. (November 2000).
"Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere--kinetochore complexes" . Human Molecular Genetics . 9 (19): 2919–2926.
doi :
10.1093/hmg/9.19.2919 .
PMID
11092768 .
Maney T, Wagenbach M, Wordeman L (September 2001).
"Molecular dissection of the microtubule depolymerizing activity of mitotic centromere-associated kinesin" . The Journal of Biological Chemistry . 276 (37): 34753–34758.
doi :
10.1074/jbc.M106626200 .
PMID
11466324 .
Cheng LJ, Zhou ZM, Li JM, Zhu H, Zhu H, Zhou YD, et al. (October 2002). "Expression of a novel HsMCAK mRNA splice variant, tsMCAK gene, in human testis". Life Sciences . 71 (23): 2741–2757.
doi :
10.1016/S0024-3205(02)02079-9 .
PMID
12383881 .
Cassimeris L, Morabito J (April 2004).
"TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly" . Molecular Biology of the Cell . 15 (4): 1580–1590.
doi :
10.1091/mbc.E03-07-0544 .
PMC
379257 .
PMID
14718566 .
Ganem NJ, Compton DA (August 2004).
"The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK" . The Journal of Cell Biology . 166 (4): 473–478.
doi :
10.1083/jcb.200404012 .
PMC
2172212 .
PMID
15302853 .
Newton CN, Wagenbach M, Ovechkina Y, Wordeman L, Wilson L (August 2004).
"MCAK, a Kin I kinesin, increases the catastrophe frequency of steady-state HeLa cell microtubules in an ATP-dependent manner in vitro" . FEBS Letters . 572 (1–3): 80–84.
doi :
10.1016/j.febslet.2004.06.093 .
PMID
15304328 .
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature . 433 (7021): 77–83.
Bibcode :
2005Natur.433...77A .
doi :
10.1038/nature03207 .
PMID
15635413 .
S2CID
4344740 .
Moore AT, Rankin KE, von Dassow G, Peris L, Wagenbach M, Ovechkina Y, et al. (May 2005).
"MCAK associates with the tips of polymerizing microtubules" . The Journal of Cell Biology . 169 (3): 391–397.
doi :
10.1083/jcb.200411089 .
PMC
2171944 .
PMID
15883193 .
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–1178.
Bibcode :
2005Natur.437.1173R .
doi :
10.1038/nature04209 .
PMID
16189514 .
S2CID
4427026 .
Ganem NJ, Upton K, Compton DA (October 2005).
"Efficient mitosis in human cells lacking poleward microtubule flux" . Current Biology . 15 (20): 1827–1832.
Bibcode :
2005CBio...15.1827G .
doi :
10.1016/j.cub.2005.08.065 .
PMID
16243029 .
S2CID
8541946 .
Helenius J, Brouhard G, Kalaidzidis Y, Diez S, Howard J (May 2006). "The depolymerizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends". Nature . 441 (7089): 115–119.
Bibcode :
2006Natur.441..115H .
CiteSeerX
10.1.1.392.1014 .
doi :
10.1038/nature04736 .
PMID
16672973 .
S2CID
4408328 .
Sun Y, Huang YC, Xu QZ, Wang HP, Bai B, Sui JL, Zhou PK (July 2006). "HIV-1 Tat depresses DNA-PK(CS) expression and DNA repair, and sensitizes cells to ionizing radiation". International Journal of Radiation Oncology, Biology, Physics . 65 (3): 842–850.
doi :
10.1016/j.ijrobp.2006.02.040 .
PMID
16751065 .
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006).
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–648.
doi :
10.1016/j.cell.2006.09.026 .
PMID
17081983 .
S2CID
7827573 .
External links
Overview of all the structural information available in the
PDB for
UniProt :
Q99661 (Kinesin-like protein KIF2C) at the
PDBe-KB .
PDB gallery
1v8j : The Crystal Structure of the Minimal Functional Domain of the Microtubule Destabilizer KIF2C Complexed with Mg-ADP
1v8k : The Crystal Structure of the Minimal Functional Domain of the Microtubule Destabilizer KIF2C Complexed with Mg-AMPPNP
2heh : Crystal Structure of the KIF2C motor domain (CASP Target)