Clinical data | |
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Routes of administration | Oral |
ATC code | |
Pharmacokinetic data | |
Bioavailability | 80–90% |
Protein binding | 5–7% |
Metabolism |
Hepatic
deacetylation Minor involvement of CYP2D6 and CYP2A6 |
Elimination half-life | 5–7 hours |
Excretion | Renal |
Identifiers | |
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CAS Number |
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PubChem CID | |
DrugBank | |
ChemSpider | |
UNII |
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KEGG | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C19H28N2O4 |
Molar mass | 348.443 g·mol−1 |
3D model ( JSmol) | |
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(what is this?) (verify) |
Roxatidine acetate is a specific and competitive histamine H2 receptor antagonist drug that is used to treat gastric ulcers, Zollinger–Ellison syndrome, erosive esophagitis, gastro-oesophageal reflux disease, and gastritis. [1] [2]
Pharmacodynamic studies showed that 150 mg of roxatidine acetate were optimal in suppressing gastric acid secretion, and that a single bedtime dose of 150 mg was more effective than a dose of 75 mg twice daily in terms of inhibiting nocturnal acid secretion. [1]
It was patented in 1979 and approved for medical use in 1986. [3] It is available in countries including China, Japan, Korea, Germany, Italy, the Netherlands, Greece and South Africa. [2]