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Ilaprazole

Clinical data
Trade names	Noltec
Routes of administration	Oral
ATC code	None
Identifiers
IUPAC name 2-[(RS)-[(4-methoxy-3-methylpyridin-2-yl)methyl]sulfinyl]-5-(1H-pyrrol-1-yl)-1H-benzimidazole
CAS Number	172152-36-2
PubChem CID	214351
ChemSpider	185839
UNII	776Q6XX45J
ChEMBL	ChEMBL2106370
Chemical and physical data
Formula	C19H18N4O2S
Molar mass	366.44 g·mol−1
3D model ( JSmol)	Interactive image
SMILES Cc1c(OC)ccnc1CS(=O)c2[nH]c3ccc(cc3n2)n4cccc4
InChI InChI=1S/C19H18N4O2S/c1-13-17(20-8-7-18(13)25-2)12-26(24)19-21-15-6-5-14(11-16(15)22-19)23-9-3-4-10-23/h3-11H,12H2,1-2H3,(H,21,22) Key:HRRXCXABAPSOCP-UHFFFAOYSA-N

Ilaprazole (trade name Noltec) is a proton pump inhibitor (PPI) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) ^[1] and duodenal ulcer. ^{[2] [3]}

It is available in strengths of 5, 10, and 20 mg.

Clinical studies show that ilaprazole is at least as potent a PPI as omeprazole when taken in equivalent doses. Studies also showed that ilaprazole significantly prevented the development of reflux oesophagitis.

Ilaprazole is developed by Il-Yang Pharmaceutical ( Korea), and is still under clinical trials with US FDA. It has launched in Korea and China for the treatment of gastric ulcer, duodenal ulcer, gastroesophageal reflux disease and erosive esophagitis. ^[4]

Ilaprazole is sold in Mexico by Chinoin Pharmaceuticals under the brand name Norutec. ^[5]

References