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Chemical compound
Gefarnate
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AHFS/
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International Drug Names |
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ATC code | |
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(2E)-3,7-dimethylocta-2,6-dien-1-yl (4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienoate
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PubChem
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CompTox Dashboard (
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ECHA InfoCard |
100.000.111
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Formula | C27H44O2 |
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Molar mass | 400.647 g·mol−1 |
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3D model (
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CC(C)=CCC/C(C)=C/CC/C(C)=C/CCC(=O)OC/C=C(C)/CCC=C(C)C
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InChI=1S/C27H44O2/c1-22(2)12-8-14-24(5)16-10-17-25(6)18-11-19-27(28)29-21-20-26(7)15-9-13-23(3)4/h12-13,16,18,20H,8-11,14-15,17,19,21H2,1-7H3/b24-16+,25-18+,26-20+ NKey:ZPACYDRSPFRDHO-ROBAGEODSA-N N
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NY
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Gefarnate is a drug used for the treatment of
gastric ulcers.
[1]
It also has been proposed for use in the treatment of
dry eye syndrome.
[2]
[3]
References
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^ Ohta Y, Kobayashi T, Imai Y, Inui K, Yoshino J, Nakazawa S (August 2005).
"Effect of gefarnate on acute gastric mucosal lesion progression in rats treated with compound 48/80, a mast cell degranulator, in comparison with that of teprenone". Biol. Pharm. Bull. 28 (8): 1424–30.
doi:
10.1248/bpb.28.1424.
PMID
16079487.
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^ Peral A, Domínguez-Godínez CO, Carracedo G, Pintor J (April 2008). "Therapeutic targets in dry eye syndrome". Drug News Perspect. 21 (3): 166–76.
PMID
18560615.
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^ Gipson IK, Hori Y, Argüeso P (April 2004).
"Character of ocular surface mucins and their alteration in dry eye disease". Ocul Surf. 2 (2): 131–48.
doi:
10.1016/s1542-0124(12)70149-0.
PMID
17216084.[
permanent dead link]