From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Proto-oncogene tyrosine-protein kinase MER is an
enzyme that in humans is encoded by the MERTK
gene .
[5]
[6]
[7]
Function
This gene is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a
transmembrane protein with two
fibronectin type-III domains , two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain.
Mutations in this gene have been associated with disruption of the
retinal pigment epithelium (RPE)
phagocytosis pathway and onset of autosomal recessive
retinitis pigmentosa (RP).
[7]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000153208 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000014361 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Graham DK, Dawson TL, Mullaney DL, Snodgrass HR, Earp HS (June 1994). "Cloning and mRNA expression analysis of a novel human protooncogene, c-mer". Cell Growth & Differentiation . 5 (6): 647–57.
PMID
8086340 .
^ Weier HU, Fung J, Lersch RA (Jun 1999).
"Assignment of protooncogene MERTK (a.k.a. c-mer) to human chromosome 2q14.1 by in situ hybridization" . Cytogenetics and Cell Genetics . 84 (1–2): 91–2.
doi :
10.1159/000015223 .
PMID
10343112 .
S2CID
43714175 .
^
a
b
"Entrez Gene: MERTK c-mer proto-oncogene tyrosine kinase" .
Further reading
Iwase T, Tanaka M, Suzuki M, Naito Y, Sugimura H, Kino I (July 1993). "Identification of protein-tyrosine kinase genes preferentially expressed in embryo stomach and gastric cancer". Biochemical and Biophysical Research Communications . 194 (2): 698–705.
doi :
10.1006/bbrc.1993.1878 .
hdl :
10271/1029 .
PMID
7688222 .
S2CID
45988423 .
Mark MR, Chen J, Hammonds RG, Sadick M, Godowsk PJ (April 1996).
"Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl" . The Journal of Biological Chemistry . 271 (16): 9785–9.
doi :
10.1074/jbc.271.16.9785 .
PMID
8621659 .
Ling L, Templeton D, Kung HJ (August 1996).
"Identification of the major autophosphorylation sites of Nyk/Mer, an NCAM-related receptor tyrosine kinase" . The Journal of Biological Chemistry . 271 (31): 18355–62.
doi :
10.1074/jbc.271.31.18355 .
PMID
8702477 .
Bonaldo MF, Lennon G, Soares MB (September 1996).
"Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Research . 6 (9): 791–806.
doi :
10.1101/gr.6.9.791 .
PMID
8889548 .
Nagata K, Ohashi K, Nakano T, Arita H, Zong C, Hanafusa H, Mizuno K (November 1996).
"Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases" . The Journal of Biological Chemistry . 271 (47): 30022–7.
doi :
10.1074/jbc.271.47.30022 .
PMID
8939948 .
Georgescu MM, Kirsch KH, Shishido T, Zong C, Hanafusa H (February 1999).
"Biological effects of c-Mer receptor tyrosine kinase in hematopoietic cells depend on the Grb2 binding site in the receptor and activation of NF-kappaB" . Molecular and Cellular Biology . 19 (2): 1171–81.
doi :
10.1128/mcb.19.2.1171 .
PMC
116046 .
PMID
9891051 .
Gal A, Li Y, Thompson DA, Weir J, Orth U, Jacobson SG, Apfelstedt-Sylla E, Vollrath D (November 2000). "Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa". Nature Genetics . 26 (3): 270–1.
doi :
10.1038/81555 .
PMID
11062461 .
S2CID
2812292 .
Thompson DA, McHenry CL, Li Y, Richards JE, Othman MI, Schwinger E, Vollrath D, Jacobson SG, Gal A (January 2002).
"Retinal dystrophy due to paternal isodisomy for chromosome 1 or chromosome 2, with homoallelism for mutations in RPE65 or MERTK, respectively" . American Journal of Human Genetics . 70 (1): 224–9.
doi :
10.1086/338455 .
PMC
384890 .
PMID
11727200 .
Yin JL, Hambly BD, Bao SS, Painter D, Bishop GA, Eris JM (September 2003). "Expression of growth arrest-specific gene 6 and its receptors in dysfunctional human renal allografts". Transplant International . 16 (9): 681–8.
doi :
10.1007/s00147-003-0593-3 .
PMID
12768229 .
S2CID
13419387 .
McHenry CL, Liu Y, Feng W, Nair AR, Feathers KL, Ding X, Gal A, Vollrath D, Sieving PA, Thompson DA (May 2004). "MERTK arginine-844-cysteine in a patient with severe rod-cone dystrophy: loss of mutant protein function in transfected cells". Investigative Ophthalmology & Visual Science . 45 (5): 1456–63.
doi :
10.1167/iovs.03-0909 .
PMID
15111602 .
Chen C, Li Q, Darrow AL, Wang Y, Derian CK, Yang J, de Garavilla L, Andrade-Gordon P, Damiano BP (June 2004).
"Mer receptor tyrosine kinase signaling participates in platelet function" . Arteriosclerosis, Thrombosis, and Vascular Biology . 24 (6): 1118–23.
doi :
10.1161/01.ATV.0000130662.30537.08 .
PMID
15130911 .
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology . 22 (6): 707–16.
doi :
10.1038/nbt971 .
PMID
15146197 .
S2CID
27764390 .
Li Y, Mahajan NP, Webster-Cyriaque J, Bhende P, Hong GK, Earp HS, Kenney S (November 2004).
"The C-mer gene is induced by Epstein-Barr virus immediate-early protein BRLF1" . Journal of Virology . 78 (21): 11778–85.
doi :
10.1128/JVI.78.21.11778-11785.2004 .
PMC
523243 .
PMID
15479819 .
Gould WR, Baxi SM, Schroeder R, Peng YW, Leadley RJ, Peterson JT, Perrin LA (April 2005). "Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses". Journal of Thrombosis and Haemostasis . 3 (4): 733–41.
doi :
10.1111/j.1538-7836.2005.01186.x .
PMID
15733062 .
S2CID
20373626 .
Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006).
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry" . Journal of Proteome Research . 4 (6): 2070–80.
doi :
10.1021/pr0502065 .
PMC
1850943 .
PMID
16335952 .
Graham DK, Salzberg DB, Kurtzberg J, Sather S, Matsushima GK, Keating AK, Liang X, Lovell MA, Williams SA, Dawson TL, Schell MJ, Anwar AA, Snodgrass HR, Earp HS (May 2006).
"Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia" . Clinical Cancer Research . 12 (9): 2662–9.
doi :
10.1158/1078-0432.CCR-05-2208 .
PMID
16675557 .
Tada A, Wada Y, Sato H, Itabashi T, Kawamura M, Tamai M, Nishida K (May 2006). "Screening of the MERTK gene for mutations in Japanese patients with autosomal recessive retinitis pigmentosa". Molecular Vision . 12 : 441–4.
PMID
16710167 .
External links
Activity Regulation Classification Kinetics Types