Clinical data | |
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Other names | Homoquinolinate |
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CAS Number | |
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PDB ligand | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.164.902 |
Chemical and physical data | |
Formula | C8H7NO4 |
Molar mass | 181.147 g·mol−1 |
3D model ( JSmol) | |
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Homoquinolinic acid (HQA) is a potent excitotoxin [1] which is a conformationally-restricted analogue of N-methyl-D-aspartate (NMDA) and a partial agonist of the main/ glutamate site of the NMDA receptor, with some selectivity for NR2B subunit-containing receptors. [2] [3] [4] It is approximately equipotent to NMDA and about five times more potent than quinolinic acid as an agonist of the NMDA receptor. [5] HQA has also been found to label a novel, yet uncharacterized binding site, which can be distinguished from the NMDA receptor with the use of 2-carboxy-3-carboxymethylquinoline (CCMQ), a selective ligand of the uncharacterized site. [6]