IDPN has been shown to kill vestibular
hair cells, disrupting normal
vestibular function, in rats,[4] mice, guinea pigs, and frogs.[5] In rodents, the loss of vestibular function results in balance-related deficits, including circling behavior, retropulsion, and head bobbing, as well as weight loss.[5] Type I hair cells are more sensitive to IDPN toxicity than Type II hair cells.[4] No regeneration of vestibular hair cells was observed, thus these effects can be considered to be irreversible.[4]
IDPN has also been shown to kill
cochlear hair cells, affecting
auditory function.[6] IDPN-induced hearing loss covered a broad range of frequencies.
^Crofton, K. M.; Janssen, R.; Prazma, J.; Pulver, S.; Barone, S. (November 1994). "The ototoxicity of 3,3'-iminodipropionitrile: functional and morphological evidence of cochlear damage". Hearing Research. 80 (2): 129–140.
doi:
10.1016/0378-5955(94)90104-X.
ISSN0378-5955.
PMID7896571.
S2CID4699179.