From Wikipedia, the free encyclopedia
Chemical compound
Becampanel
ATC code
({[(2,3-Dihydroxy-7-nitro-5-quinoxalinyl)methyl]amino}methyl)phosphonic acid
CAS Number
PubChem
CID
ChemSpider
UNII
CompTox Dashboard (
EPA )
Formula C 10 H 11 N 4 O 7 P
Molar mass 330.193 g·mol−1 3D model (
JSmol )
c1c(cc2c(c1CNCP(=O)(O)O)[nH]c(=O)c(=O)[nH]2)[N+](=O)[O-]
InChI=1S/C10H11N4O7P/c15-9-10(16)13-8-5(3-11-4-22(19,20)21)1-6(14(17)18)2-7(8)12-9/h1-2,11H,3-4H2,(H,12,15)(H,13,16)(H2,19,20,21)
Key:ABFMMCZFKUIJGQ-UHFFFAOYSA-N
Becampanel (
INN ) (code name AMP397 ) is a
quinoxalinedione
derivative
drug which acts as a
competitive antagonist of the
AMPA receptor (
IC50 = 11 nM).
[1]
[2]
[3]
[4] It was investigated as an
anticonvulsant for the treatment of
epilepsy by
Novartis , and was also looked at as a potential treatment for
neuropathic pain and
cerebral ischemia , but never completed
clinical trials .
[1]
[2]
[3]
[5]
References
^
a
b Taylor JB, Triggle DJ (2007).
Comprehensive medicinal chemistry II . Elsevier. p. 290.
ISBN
978-0-08-044513-7 .
^
a
b Kwan P, Brodie MJ (September 2007). "Emerging drugs for epilepsy". Expert Opinion on Emerging Drugs . 12 (3): 407–422.
doi :
10.1517/14728214.12.3.407 .
PMID
17874969 .
S2CID
27627114 .
^
a
b Citraro R, Aiello R, Franco V, De Sarro G, Russo E (March 2014). "Targeting α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors in epilepsy". Expert Opinion on Therapeutic Targets . 18 (3): 319–334.
doi :
10.1517/14728222.2014.874416 .
PMID
24387310 .
S2CID
1504490 .
^ World Health Organization (1988).
International Nonproprietary Names (INN) for Pharmaceutical Substances . W.H.O.
ISBN
9789240560369 .
^ Pathan SA, Jain GK, Akhter S, Vohora D, Ahmad FJ, Khar RK (September 2010). "Insights into the novel three 'D's of epilepsy treatment: drugs, delivery systems and devices". Drug Discovery Today . 15 (17–18): 717–732.
doi :
10.1016/j.drudis.2010.06.014 .
PMID
20603226 .
AMPAR Tooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
KAR Tooltip Kainate receptor
NMDAR Tooltip N-Methyl-D-aspartate receptor