From Wikipedia, the free encyclopedia
Prostaglandin E synthase (
EC
5.3.99.3, or PGE synthase) is an
enzyme involved in
eicosanoid and
glutathione metabolism, a member of
MAPEG family. It generates
prostaglandin E (PGE) from
prostaglandin H2.
[2]
[3]
The synthase generating PGE2 is a membrane-associated protein.
Isozymes
Humans express three prostaglandin-E synthase
isozymes, each encoded by a separate gene:
References
-
^ Jegerschold, C.; Pawelzik, S. -C.; Purhonen, P.; Bhakat, P.; Gheorghe, K. R.; Gyobu, N.; Mitsuoka, K.; Morgenstern, R.; Jakobsson, P. -J.; Hebert, H. (2008).
"Structural basis for induced formation of the inflammatory mediator prostaglandin E2". Proceedings of the National Academy of Sciences. 105 (32): 11110–11115.
Bibcode:
2008PNAS..10511110J.
doi:
10.1073/pnas.0802894105.
PMC
2516235.
PMID
18682561.
-
^ Murakami M, Nakatani Y, Tanioka T, Kudo I (August 2002). "Prostaglandin E synthase". Prostaglandins Other Lipid Mediat. 68–69: 383–99.
doi:
10.1016/S0090-6980(02)00043-6.
PMID
12432931.
S2CID
22246484.
-
^ Park JY, Pillinger MH, Abramson SB (June 2006). "Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases". Clin. Immunol. 119 (3): 229–40.
doi:
10.1016/j.clim.2006.01.016.
PMID
16540375.
External links
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Receptor (
ligands) |
DP (D2)Tooltip Prostaglandin D2 receptor |
DP1Tooltip Prostaglandin D2 receptor 1 | |
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DP2Tooltip Prostaglandin D2 receptor 2 | |
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EP (E2)Tooltip Prostaglandin E2 receptor |
EP1Tooltip Prostaglandin EP1 receptor | |
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EP2Tooltip Prostaglandin EP2 receptor | |
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EP3Tooltip Prostaglandin EP3 receptor | |
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EP4Tooltip Prostaglandin EP4 receptor | |
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Unsorted | |
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FP (F2α)Tooltip Prostaglandin F receptor | |
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IP (I2)Tooltip Prostacyclin receptor | |
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TP (TXA2)Tooltip Thromboxane receptor | |
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Unsorted | |
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Enzyme (
inhibitors) |
COX (
PTGS) | |
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PGD2STooltip Prostaglandin D synthase | |
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PGESTooltip Prostaglandin E synthase | |
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PGFSTooltip Prostaglandin F synthase | |
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PGI2STooltip Prostacyclin synthase | |
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TXASTooltip Thromboxane A synthase | |
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Others | |
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Activity | |
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Regulation | |
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Classification | |
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Kinetics | |
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Types | |
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