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Chemical compound
Ampiroxicam (
INN ) is a
non-steroidal anti-inflammatory drug (NSAID). It is a
prodrug of
piroxicam .
[1] It has been studied for potential
anticancer activity , but preliminary results did not show evidence of such activity.
[2]
[3]
References
^ Carty TJ, Marfat A, Moore PF, Falkner FC, Twomey TM, Weissman A (July 1993). "Ampiroxicam, an anti-inflammatory agent which is a prodrug of piroxicam". Agents Actions . 39 (3–4): 157–65.
doi :
10.1007/BF01998969 .
PMID
8304243 .
S2CID
24284281 .
^ Choi, K.-H.; Shim, J.-H.; Huong, L. D.; Cho, N.-P.; Cho, S.-D. (July 2011).
"Inhibition of myeloid cell leukemia-1 by tolfenamic acid induces apoptosis in mucoepidermoid carcinoma" . Oral Diseases . 17 (5): 469–475.
doi :
10.1111/j.1601-0825.2010.01774.x .
ISSN
1601-0825 .
PMID
21496182 .
^ Shim, Jung-Hyun; Shin, Ji-Ae; Jung, Ji-Youn; Choi, Kyeong-Hee; Choi, Eun-Sun; Cho, Nam-Pyo; Kong, Gu; Ryu, Mi Heon; Chae, Jung-Ii; Cho, Sung-Dae (March 2011).
"Chemopreventive effect of tolfenamic acid on KB human cervical cancer cells and tumor xenograft by downregulating specificity protein 1" . European journal of cancer prevention: the official journal of the European Cancer Prevention Organisation (ECP) . 20 (2): 102–111.
doi :
10.1097/CEJ.0b013e328341e38f .
ISSN
1473-5709 .
PMID
21131823 .
Receptor (
ligands )
DP (D2 ) Tooltip Prostaglandin D2 receptor
DP1 Tooltip Prostaglandin D2 receptor 1
DP2 Tooltip Prostaglandin D2 receptor 2
EP (E2 ) Tooltip Prostaglandin E2 receptor
EP1 Tooltip Prostaglandin EP1 receptor
EP2 Tooltip Prostaglandin EP2 receptor
EP3 Tooltip Prostaglandin EP3 receptor
EP4 Tooltip Prostaglandin EP4 receptor Unsorted
FP (F2α ) Tooltip Prostaglandin F receptor
IP (I2 ) Tooltip Prostacyclin receptor
TP (TXA2 ) Tooltip Thromboxane receptor Unsorted
Enzyme (
inhibitors )
COX (
PTGS )
PGD2 S Tooltip Prostaglandin D synthase
PGES Tooltip Prostaglandin E synthase
PGFS Tooltip Prostaglandin F synthase
PGI2 S Tooltip Prostacyclin synthase
TXAS Tooltip Thromboxane A synthase
Others