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Chemical compound
Apricoxib is an experimental anticancer drug and
nonsteroidal anti-inflammatory drug (NSAID).
[1] It is a
COX-2 inhibitor which is intended to improve standard therapy response in molecularly-defined models of
pancreatic cancer.
[2] It was also studied in clinical trials for
non-small-cell lung cancer.
[3] Development was abandoned in 2015 due to poor clinical trial results.
[4]
See also
References
-
^
"Apricoxib (Code C74021)". NCI Thesaurus. National Cancer Institute.
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^ Kirane A, Toombs JE, Ostapoff K, Carbon JG, Zaknoen S, Braunfeld J, et al. (September 2012).
"Apricoxib, a novel inhibitor of COX-2, markedly improves standard therapy response in molecularly defined models of pancreatic cancer". Clinical Cancer Research. 18 (18): 5031–42.
doi:
10.1158/1078-0432.CCR-12-0453.
PMC
3777527.
PMID
22829202.
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^ Edelman MJ, Tan MT, Fidler MJ, Sanborn RE, Otterson G, Sequist LV, et al. (January 2015).
"Randomized, double-blind, placebo-controlled, multicenter phase II study of the efficacy and safety of apricoxib in combination with either docetaxel or pemetrexed in patients with biomarker-selected non-small-cell lung cancer". Journal of Clinical Oncology. 33 (2): 189–94.
doi:
10.1200/JCO.2014.55.5789.
PMC
4890680.
PMID
25452446.
-
^
"Apricoxib". Adis Insight. Springer Nature Switzerland AG.
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Receptor (
ligands) |
DP (D2)Tooltip Prostaglandin D2 receptor |
DP1Tooltip Prostaglandin D2 receptor 1 | |
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DP2Tooltip Prostaglandin D2 receptor 2 | |
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EP (E2)Tooltip Prostaglandin E2 receptor |
EP1Tooltip Prostaglandin EP1 receptor | |
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EP2Tooltip Prostaglandin EP2 receptor | |
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EP3Tooltip Prostaglandin EP3 receptor | |
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EP4Tooltip Prostaglandin EP4 receptor | |
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FP (F2α)Tooltip Prostaglandin F receptor | |
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IP (I2)Tooltip Prostacyclin receptor | |
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TP (TXA2)Tooltip Thromboxane receptor | |
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Enzyme (
inhibitors) |
COX (
PTGS) | |
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PGD2STooltip Prostaglandin D synthase | |
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PGESTooltip Prostaglandin E synthase | |
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PGFSTooltip Prostaglandin F synthase | |
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PGI2STooltip Prostacyclin synthase | |
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TXASTooltip Thromboxane A synthase | |
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