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Nonsteroidal anti-inflammatory prodrug
Indometacin farnesil
AHFS /
Drugs.com
International Drug Names
Routes of administration Oral
ATC code
Legal status
In general: ℞ (Prescription only)
Metabolism To
indometacin
Elimination half-life 1.5 hours
Excretion Renal
(2E ,6E )-3,7,11-trimethyldodeca-2,6,10-trien-1-yl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H -indol-3-yl]acetate
CAS Number
PubChem
CID
ChemSpider
UNII
CompTox Dashboard (
EPA )
ECHA InfoCard
100.242.585
Formula C 34 H 40 Cl N O 4
Molar mass 562.15 g·mol−1 3D model (
JSmol )
CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)OCC=C(C)CCC=C(C)CCC=C(C)C
InChI=1S/C34H40ClNO4/c1-23(2)9-7-10-24(3)11-8-12-25(4)19-20-40-33(37)22-30-26(5)36(32-18-17-29(39-6)21-31(30)32)34(38)27-13-15-28(35)16-14-27/h9,11,13-19,21H,7-8,10,12,20,22H2,1-6H3/b24-11+,25-19+
Y Key:CFIGYZZVJNJVDQ-LMJOQDENSA-N
Y
(verify)
Indometacin farnesil (
INN ) is a
prodrug of the
nonsteroidal anti-inflammatory drug (NSAID)
indometacin , designed to reduce the occurrence of side-effects by esterification of the carboxyl group on indometacin with
farnesol . Indometacin farnesil was first approved in
Japan in 1991, and is available in Japan and
Indonesia , under the trade names Infree and Dialon , respectively.
External links
Receptor (
ligands )
DP (D2 ) Tooltip Prostaglandin D2 receptor
DP1 Tooltip Prostaglandin D2 receptor 1
DP2 Tooltip Prostaglandin D2 receptor 2
EP (E2 ) Tooltip Prostaglandin E2 receptor
EP1 Tooltip Prostaglandin EP1 receptor
EP2 Tooltip Prostaglandin EP2 receptor
EP3 Tooltip Prostaglandin EP3 receptor
EP4 Tooltip Prostaglandin EP4 receptor Unsorted
FP (F2α ) Tooltip Prostaglandin F receptor
IP (I2 ) Tooltip Prostacyclin receptor
TP (TXA2 ) Tooltip Thromboxane receptor Unsorted
Enzyme (
inhibitors )
COX (
PTGS )
PGD2 S Tooltip Prostaglandin D synthase
PGES Tooltip Prostaglandin E synthase
PGFS Tooltip Prostaglandin F synthase
PGI2 S Tooltip Prostacyclin synthase
TXAS Tooltip Thromboxane A synthase
Others