From Wikipedia, the free encyclopedia
Chemical compound
Fluproquazone (trade name Tormosyl , RF 46-790 ) was a
quinazolinone derivative with potent
analgesic ,
antipyretic , and
anti-inflammatory effects discovered by
Sandoz .
[1]
[2]
[3]
[4] It was withdrawn during development due to
liver toxicity .
[5] : 370
[6] : 520
References
^ Haanaes HR, Benterud UJ, Skoglund LA (November 1986). "RF 46-790 versus paracetamol: effect on post-operative pain". International Journal of Clinical Pharmacology, Therapy, and Toxicology . 24 (11): 598–601.
PMID
3491794 .
^ Mohing W, Suckert R, Lataste X (1981). "Comparative study of fluproquazone in the management of post-operative pain". Arzneimittel-Forschung . 31 (5a): 918–20.
PMID
6973986 .
^ Wheatley D (May 1982). "Analgesic properties of fluproquazone". Rheumatology and Rehabilitation . 21 (2): 98–100.
doi :
10.1093/rheumatology/21.2.98 .
PMID
7043713 .
^ Fankhauser S, Laube W, Marti HR, Schultheiss HR, Vögtlin J, von Graffenried B (1981). "Antipyretic activity of fluproquazone in man". Arzneimittel-Forschung . 31 (5a): 934–5.
PMID
6973990 .
^ Lewis JH, Stine JG (2013). "Nonsteroidal Antiinflammatory Drugs and Leukotriene Receptor Antagonists". In Kaplowitz N, DeLeve LD (eds.). Drug-induced Liver Disease (third ed.). Elsevier Inc.
ISBN
9780123878175 .
^ Zimmerman HJ (1999). Hepatotoxicity: The Adverse Effects of Drugs and Other Chemicals on the Liver . Lippincott Williams & Wilkins.
ISBN
9780781719520 .
Receptor (
ligands )
DP (D2 ) Tooltip Prostaglandin D2 receptor
DP1 Tooltip Prostaglandin D2 receptor 1
DP2 Tooltip Prostaglandin D2 receptor 2
EP (E2 ) Tooltip Prostaglandin E2 receptor
EP1 Tooltip Prostaglandin EP1 receptor
EP2 Tooltip Prostaglandin EP2 receptor
EP3 Tooltip Prostaglandin EP3 receptor
EP4 Tooltip Prostaglandin EP4 receptor Unsorted
FP (F2α ) Tooltip Prostaglandin F receptor
IP (I2 ) Tooltip Prostacyclin receptor
TP (TXA2 ) Tooltip Thromboxane receptor Unsorted
Enzyme (
inhibitors )
COX (
PTGS )
PGD2 S Tooltip Prostaglandin D synthase
PGES Tooltip Prostaglandin E synthase
PGFS Tooltip Prostaglandin F synthase
PGI2 S Tooltip Prostacyclin synthase
TXAS Tooltip Thromboxane A synthase
Others