From Wikipedia, the free encyclopedia
Membrane dipeptidase (
EC
3.4.13.19 , renal dipeptidase , dehydropeptidase I (DPH I) , dipeptidase , aminodipeptidase , dipeptide hydrolase , dipeptidyl hydrolase , nonspecific dipeptidase , glycosyl-phosphatidylinositol-anchored renal dipeptidase , MBD , MDP , leukotriene D4 hydrolase ) is an
enzyme .
[1]
[2]
[3]
[4] This enzyme
catalyses the following
chemical reaction
Hydrolysis of
dipeptides (e.g.,
leukotriene D4 ,
cystinyl-bis-glycine , some
β-lactam antibiotics (e.g.,
carbapenem ))
This membrane-bound, zinc enzyme has broad specificity.
Inhibitors include
bestatin and
cilastatin .
Genes
References
^ Campbell BJ, Lin YC, Davis RV, Ballew E (May 1966). "The purification and properties of a particulate renal dipeptidase". Biochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation . 118 (2): 371–86.
doi :
10.1016/s0926-6593(66)80046-2 .
PMID
5961612 .
^ Campbell, B.J. (1970). "Renal dipeptidase". Methods Enzymol . 19 : 722–729.
doi :
10.1016/0076-6879(70)19059-8 .
^ Kropp H, Sundelof JG, Hajdu R, Kahan FM (July 1982).
"Metabolism of thienamycin and related carbapenem antibiotics by the renal dipeptidase, dehydropeptidase" . Antimicrobial Agents and Chemotherapy . 22 (1): 62–70.
doi :
10.1128/aac.22.1.62 .
PMC
183675 .
PMID
7125632 .
^ Hooper NM, Keen JN, Turner AJ (January 1990).
"Characterization of the glycosyl-phosphatidylinositol-anchored human renal dipeptidase reveals that it is more extensively glycosylated than the pig enzyme" . The Biochemical Journal . 265 (2): 429–33.
doi :
10.1042/bj2650429 .
PMC
1136904 .
PMID
2137335 .
External links
Receptor (
ligands )
BLT Tooltip Leukotriene B4 receptor
BLT1 Tooltip Leukotriene B4 receptor 1
BLT2 Tooltip Leukotriene B4 receptor 2
CysLT Tooltip Cysteinyl leukotriene receptor
CysLT1 Tooltip Cysteinyl leukotriene receptor 1
CysLT2 Tooltip Cysteinyl leukotriene receptor 2
CysLTE Tooltip Cysteinyl leukotriene receptor E
Enzyme (
inhibitors )
5-LOX Tooltip Arachidonate 5-lipoxygenase
12-LOX Tooltip Arachidonate 12-lipoxygenase
15-LOX Tooltip Arachidonate 15-lipoxygenase
LTA4 H Tooltip Leukotriene A4 hydrolase
LTB4 H Tooltip Leukotriene B4 ω-hydroxylase
LTC4 S Tooltip Leukotriene C4 synthase
LTC4 H Tooltip Leukotriene C4 hydrolase
LTD4 Tooltip Leukotriene D4 hydrolase
Others
Activity Regulation Classification Kinetics Types