Cerebrolysin has also been studied for potential use with a wide variety of neurodegenerative disorders, though research is preliminary.[1] No benefit in the treatment of acute
stroke has been found and an increased rate of spontaneous adverse events requiring
hospitalization is reported.[2] Some positive effects have been reported when cerebrolysin is used to treat
vascular dementia.[3]
Research
Stroke
Reviews emphasize the need for further high quality studies.[2] In addition, use might be associated with a higher rate of spontaneous adverse events requiring hospitalization.[2] Studies of ischemic stroke in Asian subpopulations found an absence of benefit.[4]
In trials studying the use of cerebrolysin after acute stroke, there was no increased risk of "serious adverse events" requiring hospitalization. These were specifically defined as:
"...any untoward medical occurrence that, at any dose, resulted in death, [was] life‐threatening, required inpatient hospitalisation or resulted in prolongation of existing hospitalisation, resulted in persistent or significant disability/incapacity, [was] a congenital anomaly/birth defect, or [was] a medically important event or reaction”.[14]
Mechanism of action
In vitro and animal studies suggest neurotrophic effects of cerebrolysin similar to endogenous neurotrophic factors, though its specific molecular pharmacodynamics are not clear.[15] Studies of
dementia suggest decreased
beta-amyloid deposition.[16]
Regulatory
Cerebrolysin is not a scheduled drug in the United States.[17][18]
References
^Windisch M, Gschanes A, Hutter-Paier B (1998). "Neurotrophic activities and therapeutic experience with a brain derived peptide preparation". Ageing and Dementia. Journal of Neural Transmission. Supplementa. Vol. 53. pp. 289–98.
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10.1007/978-3-7091-6467-9_25.
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PMID9700665.
^
abcZiganshina LE, Abakumova T, Nurkhametova D, Ivanchenko K, et al. (Cochrane Stroke Group) (October 2023). "Cerebrolysin for acute ischaemic stroke". The Cochrane Database of Systematic Reviews. 2023 (10): CD007026.
doi:
10.1002/14651858.CD007026.pub7.
PMC 10565895.
PMID37818733.
^Fan F, Liu H, Shi X, Ai Y, Liu Q, Cheng Y (2022). "The Efficacy and Safety of Alzheimer's Disease Therapies: An Updated Umbrella Review". Journal of Alzheimer's Disease. 85 (3): 1195–1204.
doi:
10.3233/JAD-215423.
PMID34924395.
S2CID245311001.
^El Sayed I, Zaki A, Fayed AM, Shehata GM, Abdelmonem S (April 2018). "A meta-analysis of the effect of different neuroprotective drugs in management of patients with traumatic brain injury". Neurosurgical Review. 41 (2): 427–438.
doi:
10.1007/s10143-016-0775-y.
PMID27539610.
S2CID3980956.
^Xiao S, Xue H, Li G, Yuan C, Li X, Chen C, et al. (February 2012). "Therapeutic effects of cerebrolysin added to risperidone in patients with schizophrenia dominated by negative symptoms". The Australian and New Zealand Journal of Psychiatry. 46 (2): 153–160.
doi:
10.1177/0004867411433213.
PMID22311531.
S2CID206397952.
^Nasiri J, Safavifar F (June 2017). "Effect of cerebrolysin on gross motor function of children with cerebral palsy: a clinical trial". Acta Neurologica Belgica. 117 (2): 501–505.
doi:
10.1007/s13760-016-0743-x.
PMID28074392.
S2CID3805375.
^Allam AF, Abotakia TA, Koptan W (July 2018). "Role of Cerebrolysin in cervical spondylotic myelopathy patients: a prospective randomized study". The Spine Journal. 18 (7): 1136–1142.
doi:
10.1016/j.spinee.2017.11.002.
PMID29155000.
S2CID23283518.
^Menon PK, Muresanu DF, Sharma A, Mössler H, Sharma HS (February 2012). "Cerebrolysin, a mixture of neurotrophic factors induces marked neuroprotection in spinal cord injury following intoxication of engineered nanoparticles from metals". CNS & Neurological Disorders Drug Targets. 11 (1): 40–49.
doi:
10.2174/187152712799960781.
PMID22229324.
^Masliah E, Díez-Tejedor E (April 2012). "The pharmacology of neurotrophic treatment with Cerebrolysin: brain protection and repair to counteract pathologies of acute and chronic neurological disorders". Drugs of Today. 48 (Suppl A): 3–24.
doi:
10.1358/dot.2012.48(Suppl.A).1739716.
PMID22514792.
S2CID23181962.