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Lentinan
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Chemical and physical data
Molar mass~ 500,000 Da
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Lentinan is a polysaccharide isolated from the fruit body of shiitake mushroom (Lentinula edodes).

Chemistry

Lentinan is a β-1,3 beta-glucan with β-1,6 branching. It has a molecular weight of 500,000 Da and specific rotation of +14-22° (NaOH).

Research

Preclinical studies

An in vitro experiment showed lentinan stimulated production of white blood cells in the human cell line U937. [1] Lentinan is thought to be inactive in humans when given orally and is therefore administered intravenously. The authors of an in vivo study of lentinan suggested that the compound may be active when administered orally in mice. [2]

Human clinical trials

Lentinan has been the subject of a limited number of clinical studies in cancer patients in Japan; [3] [4] [5] [6] [7] [8] [9] [10] however, evidence of efficacy is lacking. [11] [12]

Adverse effects

Lentinan has been reported to cause shiitake mushroom dermatitis. [13]

See also

References

  1. ^ Sia GM, Candlish JK (March 1999). "Effects of shiitake (Lentinus edodes) extract on human neutrophils and the U937 monocytic cell line". Phytotherapy Research. 13 (2): 133–137. doi: 10.1002/(SICI)1099-1573(199903)13:2<133::AID-PTR398>3.0.CO;2-O. PMID  10190187.
  2. ^ Ng ML, Yap AT (October 2002). "Inhibition of human colon carcinoma development by lentinan from shiitake mushrooms (Lentinus edodes)". Journal of Alternative and Complementary Medicine. 8 (5): 581–589. doi: 10.1089/107555302320825093. PMID  12470439.
  3. ^ Yang P, Liang M, Zhang Y, Shen B (August 2008). "Clinical application of a combination therapy of lentinan, multi-electrode RFA and TACE in HCC". Advances in Therapy. 25 (8): 787–794. doi: 10.1007/s12325-008-0079-x. PMID  18670743. S2CID  33140754.
  4. ^ Nimura H, Mitsumori N, Takahashi N, Kashimura H, Takayama S, Kashiwagi H, Yanaga K (June 2006). "[S-1 combined with lentinan in patients with unresectable or recurrent gastric cancer]". Gan to Kagaku Ryoho. Cancer & Chemotherapy (in Japanese). 33 Suppl 1 (1): 106–109. PMID  16897983.
  5. ^ Nakano H, Namatame K, Nemoto H, Motohashi H, Nishiyama K, Kumada K (1999). "A multi-institutional prospective study of lentinan in advanced gastric cancer patients with unresectable and recurrent diseases: effect on prolongation of survival and improvement of quality of life. Kanagawa Lentinan Research Group". Hepato-Gastroenterology. 46 (28): 2662–2668. PMID  10522061.
  6. ^ Oba K, Kobayashi M, Matsui T, Kodera Y, Sakamoto J (July 2009). "Individual patient based meta-analysis of lentinan for unresectable/recurrent gastric cancer". Anticancer Research. 29 (7): 2739–2745. PMID  19596954.
  7. ^ Hazama S, Watanabe S, Ohashi M, Yagi M, Suzuki M, Matsuda K, et al. (July 2009). "Efficacy of orally administered superfine dispersed lentinan (beta-1,3-glucan) for the treatment of advanced colorectal cancer". Anticancer Research. 29 (7): 2611–2617. PMID  19596936.
  8. ^ Kataoka H, Shimura T, Mizoshita T, Kubota E, Mori Y, Mizushima T, et al. (2009). "Lentinan with S-1 and paclitaxel for gastric cancer chemotherapy improve patient quality of life". Hepato-Gastroenterology. 56 (90): 547–550. PMID  19579640.
  9. ^ Isoda N, Eguchi Y, Nukaya H, Hosho K, Suga Y, Suga T, et al. (2009). "Clinical efficacy of superfine dispersed lentinan (beta-1,3-glucan) in patients with hepatocellular carcinoma". Hepato-Gastroenterology. 56 (90): 437–441. PMID  19579616.
  10. ^ Shimizu K, Watanabe S, Watanabe S, Matsuda K, Suga T, Nakazawa S, Shiratori K (2009). "Efficacy of oral administered superfine dispersed lentinan for advanced pancreatic cancer". Hepato-Gastroenterology. 56 (89): 240–244. PMID  19453066.
  11. ^ "Lentinan". WebMD. Retrieved June 10, 2017.
  12. ^ "Lentinan". Memorial Sloan Kettering Cancer Center. Retrieved June 10, 2017.
  13. ^ Nakamura T (August 1992). "Shiitake (Lentinus edodes) dermatitis". Contact Dermatitis. 27 (2): 65–70. doi: 10.1111/j.1600-0536.1992.tb05211.x. PMID  1395630. S2CID  7320474.

External links

  • Lentinan effects (antitumor and others)
  • Memorial Sloan-Kettering Cancer Center's page for Lentinan.
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