From Wikipedia, the free encyclopedia
Medication
Trafermin (brand name Fiblast), also known as recombinant human basic fibroblast growth factor (rhbFGF), is a
recombinant form of human
basic fibroblast growth factor (bFGF) which is marketed in
Japan as a
topical
spray for the treatment of
skin ulcers.
[2]
[3]
[1] It is also currently in preregistration for the treatment of
periodontitis.
[2]
[4] As a recombinant form of bFGF, trafermin is a
potent
agonist of the
FGFR1,
FGFR2,
FGFR3, and
FGFR4.
[5]
[6] The drug has been marketed in Japan since June 2001.[
citation needed]
References
- ^
a
b Han SK (15 September 2015).
"Growth Factor Therapy". Innovations and Advances in Wound Healing. Springer. pp. 206–.
ISBN
978-3-662-46587-5.
- ^
a
b
"Trafermin - Kaken Pharmaceutical". AdisInsight. Springer Nature Switzerland AG.
-
^
"Trafermin". Drugs.com.
-
^ Kitamura M, Akamatsu M, Kawanami M, Furuichi Y, Fujii T, Mori M, et al. (April 2016).
"Randomized Placebo-Controlled and Controlled Non-Inferiority Phase III Trials Comparing Trafermin, a Recombinant Human Fibroblast Growth Factor 2, and Enamel Matrix Derivative in Periodontal Regeneration in Intrabony Defects". Journal of Bone and Mineral Research. 31 (4): 806–814.
doi:
10.1002/jbmr.2738.
PMID
26547659.
-
^ Barnard JA, McHugh KM (10 May 2006).
"Growth Factors in the Gastrointestinal Tract". In Barrett KE, Ghishan FK, Merchant JL, Said HM, Wood JD (eds.). Physiology of the Gastrointestinal Tract. Academic Press. pp. 216–.
ISBN
978-0-08-045615-7.
-
^ Hamid M. Said (4 July 2012).
Physiology of the Gastrointestinal Tract, Two Volume Set. Academic Press. pp. 235–.
ISBN
978-0-12-382027-3.
External links
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Angiopoietin | |
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CNTF | |
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EGF (ErbB) | |
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FGF |
FGFR1 | |
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FGFR2 |
- Agonists:
Ersofermin
-
FGF (
1,
2 (bFGF),
3,
4,
5,
6,
7 (
KGF),
8,
9,
10 (KGF2),
17,
18,
22)
-
Palifermin
-
Repifermin
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Selpercatinib
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Sprifermin
-
Trafermin
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FGFR3 | |
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FGFR4 | |
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Unsorted | |
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HGF (c-Met) | |
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IGF | |
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LNGF (p75NTR) | |
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PDGF | |
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RET (GFL) | |
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SCF (c-Kit) | |
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TGFβ | |
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Trk |
TrkA |
- Negative allosteric modulators:
VM-902A
|
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TrkB |
- Agonists:
3,7-DHF
-
3,7,8,2'-THF
-
4'-DMA-7,8-DHF
-
7,3'-DHF
-
7,8-DHF
-
7,8,2'-THF
-
7,8,3'-THF
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Amitriptyline
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BDNF
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BNN-20
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Deoxygedunin
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Deprenyl
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Diosmetin
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DMAQ-B1
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HIOC
-
LM22A-4
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N-Acetylserotonin
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NT-3
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NT-4
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Norwogonin (5,7,8-THF)
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R7
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R13
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TDP6
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TrkC | |
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VEGF | |
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Others |
- Additional growth factors:
Adrenomedullin
-
Colony-stimulating factors (see
here instead)
-
Connective tissue growth factor (CTGF)
-
Ephrins (
A1,
A2,
A3,
A4,
A5,
B1,
B2,
B3)
-
Erythropoietin (see
here instead)
-
Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
-
Glia maturation factor (GMF)
-
Hepatoma-derived growth factor (HDGF)
-
Interleukins/
T-cell growth factors (see
here instead)
-
Leukemia inhibitory factor (LIF)
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Macrophage-stimulating protein (MSP; HLP, HGFLP)
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Midkine (NEGF2)
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Migration-stimulating factor (MSF; PRG4)
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Oncomodulin
-
Pituitary adenylate cyclase-activating peptide (PACAP)
-
Pleiotrophin
-
Renalase
-
Thrombopoietin (see
here instead)
-
Wnt signaling proteins
- Additional growth factor receptor modulators:
Cerebrolysin (neurotrophin mixture)
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