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Anticonvulsant
Phenacemide (
INN ,
BAN ) (brand name Phenurone ), also known as phenylacetylurea , is an
anticonvulsant of the
ureide (acetylurea) class.
[1] It is a
congener and ring-opened
analogue of
phenytoin (a
hydantoin ),
[2]
[3] and is structurally related to the
barbiturates and to other
hydantoins .
[4] Phenacemide was introduced in 1949 for the treatment of
epilepsy , but was eventually withdrawn due to
toxicity .
[2]
[3]
See also
References
^ Ganellin CR, Triggle DJ (21 November 1996).
Dictionary of Pharmacological Agents . CRC Press. pp. 1578–.
ISBN
978-0-412-46630-4 .
^
a
b Prasad JP (2010).
"Central Nervous System" . Conceptual Pharmacology . Universities Press. pp. 236–.
ISBN
978-81-7371-679-9 .
^
a
b Saxena AK, Saxena M (1995). "Developments in anticonvulsants". In deStevens G, Zingel V, Leschke C, Hoeprich P, Schultz R, Mehrotra P, et al. (eds.). Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques . Vol. 44. Basel: Birkhäuser. pp. 185–291.
doi :
10.1007/978-3-0348-7161-7_6 .
ISBN
978-3-0348-7161-7 .
PMID
7644666 .
^ Kadam SS, Mahadik KR, Bothara KG (1 July 2007).
"Central Nervous System Depresants" . Principles of Medicinal Chemistry . Vol. II. Pragati Books Pvt. Ltd. pp. 147–.
ISBN
978-81-85790-03-9 .
Further reading
External links
Calcium
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Potassium
VGKCs Tooltip Voltage-gated potassium channels
IRKs Tooltip Inwardly rectifying potassium channel
KCa Tooltip Calcium-activated potassium channel
K2Ps Tooltip Tandem pore domain potassium channel
Sodium
VGSCs Tooltip Voltage-gated sodium channels
ENaC Tooltip Epithelial sodium channel
ASICs Tooltip Acid-sensing ion channel
Chloride
CaCCs Tooltip Calcium-activated chloride channel
CFTR Tooltip Cystic fibrosis transmembrane conductance regulator
Unsorted
Others
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LGICs Tooltip Ligand gated ion channels