From Wikipedia, the free encyclopedia
Type of drug
A potassium channel opener is a type of
drug which facilitates
ion transmission through
potassium channels .
Examples
Some examples include:
See also
References
^ Mizutani S, Prasad SM, Sellitto AD, Schuessler RB, Damiano RJ, Lawton JS (August 2005).
"Myocyte volume and function in response to osmotic stress: observations in the presence of an adenosine triphosphate-sensitive potassium channel opener" . Circulation . 112 (9 Suppl): I219–23.
doi :
10.1161/CIRCULATIONAHA.104.523746 .
PMID
16159820 .
^ Wang T (February 2003). "The effects of the potassium channel opener minoxidil on renal electrolytes transport in the loop of henle". J. Pharmacol. Exp. Ther . 304 (2): 833–40.
doi :
10.1124/jpet.102.043380 .
PMID
12538840 .
S2CID
6948410 .
^ Sudo H, Yogo K, Ishizuka N, Otsuka H, Horie S, Saito K (November 2008).
"Nicorandil, a potassium channel opener and nitric oxide donor, improves the frequent urination without changing the blood pressure in rats with partial bladder outlet obstruction" . Biol. Pharm. Bull . 31 (11): 2079–82.
doi :
10.1248/bpb.31.2079 .
PMID
18981577 .
^ Stojnic N, Gojkovic-Bukarica L, Peric M, et al. (June 2007).
"Potassium channel opener pinacidil induces relaxation of the isolated human radial artery" . J. Pharmacol. Sci . 104 (2): 122–9.
doi :
10.1254/jphs.FP0061434 .
PMID
17538231 . [
dead link ]
^ Rundfeldt C (October 1997). "The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells". European Journal of Pharmacology . 336 (2–3): 243–9.
doi :
10.1016/S0014-2999(97)01249-1 .
PMID
9384239 .
^ Main MJ, Cryan JE, Dupere JR, Cox B, Clare JJ, Burbidge SA (August 2000). "Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine". Molecular Pharmacology . 58 (2): 253–62.
doi :
10.1124/mol.58.2.253 .
PMID
10908292 .
S2CID
11112809 .
^
a
b
c
d
e
f Enyedi P, Czirják G (Apr 2010).
"Molecular background of leak K+ currents: two-pore domain potassium channels" (PDF) . Physiological Reviews . 90 (2): 559–605.
doi :
10.1152/physrev.00029.2009 .
PMID
20393194 .
S2CID
9358238 .
^
a
b
c
d
e
f Lotshaw DP (2007). "Biophysical, pharmacological, and functional characteristics of cloned and native mammalian two-pore domain K+ channels".
Cell Biochemistry and Biophysics . 47 (2): 209–56.
doi :
10.1007/s12013-007-0007-8 .
PMID
17652773 .
S2CID
12759521 .
^
a
b Fink M, Lesage F, Duprat F, Heurteaux C, Reyes R, Fosset M, Lazdunski M (Jun 1998).
"A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids" . The EMBO Journal . 17 (12): 3297–308.
doi :
10.1093/emboj/17.12.3297 .
PMC
1170668 .
PMID
9628867 .
^ Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (Mar 2001).
"Potassium leak channels and the KCNK family of two-P-domain subunits" . Nature Reviews. Neuroscience . 2 (3): 175–84.
doi :
10.1038/35058574 .
PMID
11256078 .
S2CID
9682396 .
^ Sano Y, Inamura K, Miyake A, Mochizuki S, Kitada C, Yokoi H, Nozawa K, Okada H, Matsushime H, Furuichi K (Jul 2003).
"A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord" . The Journal of Biological Chemistry . 278 (30): 27406–12.
doi :
10.1074/jbc.M206810200 .
PMID
12754259 .
S2CID
22656809 .
^ Czirják G, Tóth ZE, Enyedi P (Apr 2004).
"The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin" (PDF) . The Journal of Biological Chemistry . 279 (18): 18550–8.
doi :
10.1074/jbc.M312229200 .
PMID
14981085 .
S2CID
21219622 .
^ Meadows HJ, Randall AD (Mar 2001). "Functional characterisation of human TASK-3, an acid-sensitive two-pore domain potassium channel". Neuropharmacology . 40 (4): 551–9.
doi :
10.1016/S0028-3908(00)00189-1 .
PMID
11249964 .
S2CID
20181576 .
^ Patel AJ, Honoré E, Lesage F, Fink M, Romey G, Lazdunski M (May 1999). "Inhalational anesthetics activate two-pore-domain background K+ channels". Nature Neuroscience . 2 (5): 422–6.
doi :
10.1038/8084 .
PMID
10321245 .
S2CID
23092576 .
^ Gray AT, Zhao BB, Kindler CH, Winegar BD, Mazurek MJ, Xu J, Chavez RA, Forsayeth JR, Yost CS (Jun 2000). "Volatile anesthetics activate the human tandem pore domain baseline K+ channel KCNK5". Anesthesiology . 92 (6): 1722–30.
doi :
10.1097/00000542-200006000-00032 .
PMID
10839924 .
S2CID
45487917 .
^ Rogawski MA, Bazil CW (Jul 2008).
"New molecular targets for antiepileptic drugs: alpha(2)delta, SV2A, and K(v)7/KCNQ/M potassium channels" . Current Neurology and Neuroscience Reports . 8 (4): 345–52.
doi :
10.1007/s11910-008-0053-7 .
PMC
2587091 .
PMID
18590620 .
^ Premoli I, Rossini PG, Goldberg PY, Posadas K, Green L, Yogo N, Pimstone S, Abela E, Beatch GN, Richardson MP (November 2019).
"TMS as a pharmacodynamic indicator of cortical activity of a novel anti-epileptic drug, XEN1101" . Annals of Clinical and Translational Neurology . 6 (11): 2164–2174.
doi :
10.1002/acn3.50896 .
PMC
6856596 .
PMID
31568714 . XEN1101 is a novel positive allosteric modulator ("opener") of the potassium channel KCNQ2/3 (Kv7.2/7.3) currently being developed by Xenon Pharmaceuticals Inc. for the treatment of focal epilepsy.
Calcium
VDCCs Tooltip Voltage-dependent calcium channels
Potassium
VGKCs Tooltip Voltage-gated potassium channels
IRKs Tooltip Inwardly rectifying potassium channel
KCa Tooltip Calcium-activated potassium channel
K2Ps Tooltip Tandem pore domain potassium channel
Sodium
VGSCs Tooltip Voltage-gated sodium channels
ENaC Tooltip Epithelial sodium channel
ASICs Tooltip Acid-sensing ion channel
Chloride
CaCCs Tooltip Calcium-activated chloride channel
CFTR Tooltip Cystic fibrosis transmembrane conductance regulator
Unsorted
Others
TRPs Tooltip Transient receptor potential channels
LGICs Tooltip Ligand gated ion channels