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Chemical compound
Laudexium metilsulfate
Other names Laudolissin
Routes of administration IV
Legal status
discontinued from clinical use
Bioavailability 100% (IV)
1-[(3,4-Dimethoxyphenyl)methyl]-2-[10-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H -isoquinolin-2-ium-2-yl]decyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H -isoquinolin-2-ium methyl sulfate
CAS Number
PubChem
CID
ChemSpider
UNII
Formula C 54 H 80 N 2 O 16 S 2
Molar mass 1077 .35 g·mol−1 3D model (
JSmol )
C[N+]1(CCC2=CC(=C(C=C2C1CC3=CC(=C(C=C3)OC)OC)OC)OC)CCCCCCCCCC[N+]4(CCC5=CC(=C(C=C5C4CC6=CC(=C(C=C6)OC)OC)OC)OC)C.COS(=O)(=O)[O-].COS(=O)(=O)[O-]
InChI=1S/C52H74N2O8.2CH4O4S/c1-53(27-23-39-33-49(59-7)51(61-9)35-41(39)43(53)29-37-19-21-45(55-3)47(31-37)57-5)25-17-15-13-11-12-14-16-18-26-54(2)28-24-40-34-50(60-8)52(62-10)36-42(40)44(54)30-38-20-22-46(56-4)48(32-38)58-6;2*1-5-6(2,3)4/h19-22,31-36,43-44H,11-18,23-30H2,1-10H3;2*1H3,(H,2,3,4)/q+2;;/p-2
N Key:LADQAYSLFLCKOD-UHFFFAOYSA-L
N
N Y
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Laudexium metilsulfate is a
neuromuscular blocking drug or
skeletal muscle relaxant in the category of non-depolarizing
neuromuscular-blocking drugs , used adjunctively in surgical
anesthesia to facilitate endotracheal
intubation and to provide
skeletal muscle relaxation during
surgery or
mechanical ventilation .
Laudexium
[1] is no longer used in clinical practice, though it was introduced clinically in the early 1950s.[
citation needed ] It has about half the potency, a slower onset of action and a duration of action much longer than that of d -
tubocurarine .
[2] As with all clinically established (as well as experimental agents) with a non-depolarizing mechanism of action, its pharmacological action can be antagonized by anticholinesterases.
The displacement of laudexium from clinical use was assured owing to recurrent reports of significant post-operative re-curarization.
[3]
References
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