From Wikipedia, the free encyclopedia
Bimakalim
Names
Preferred IUPAC name
2,2-Dimethyl-4-(2-oxopyridin-1(2H )-yl)-2H -1-benzopyran-6-carbonitrile
Identifiers
ChEMBL
ChemSpider
UNII
InChI=1S/C17H14N2O2/c1-17(2)10-14(19-8-4-3-5-16(19)20)13-9-12(11-18)6-7-15(13)21-17/h3-10H,1-2H3
Key: JTVSKASWNROQQF-UHFFFAOYSA-N
CC1(C=C(c2cc(ccc2O1)C#N)n3ccccc3=O)C
Properties
C 17 H 14 N 2 O 2
Molar mass
278.311 g·mol−1
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Chemical compound
Bimakalim is a
potassium channel opener .
[1] It can be prepared from
2-acetyl-4-cyanophenol .
[2]
References
^ Puddu, Paolo Emilio; Garlid, Keith D; Monti, Francesco; Iwashiro, Katsunori; Picard, Sandra; Dawodu, Amos Adeyemo; Criniti, Anna; Ruvolo, Giovanni; Campa, Pietro Paolo (2006).
"Bimakalim: A Promising KATP Channel Activating Agent" . Cardiovascular Drug Reviews . 18 : 25.
doi :
10.1111/j.1527-3466.2000.tb00031.x .
^ Bergmann, Rolf; Gericke, Rolf (1990). "Synthesis and antihypertensive activity of 4-(1,2-dihydro-2-oxo-1-pyridyl)-2H-1-benzopyrans and related compounds, new potassium channel activators". Journal of Medicinal Chemistry . 33 (2). American Chemical Society (ACS): 492–504.
doi :
10.1021/jm00164a005 .
ISSN
0022-2623 .
Calcium
VDCCs Tooltip Voltage-dependent calcium channels
Potassium
VGKCs Tooltip Voltage-gated potassium channels
IRKs Tooltip Inwardly rectifying potassium channel
KCa Tooltip Calcium-activated potassium channel
K2Ps Tooltip Tandem pore domain potassium channel
Sodium
VGSCs Tooltip Voltage-gated sodium channels
ENaC Tooltip Epithelial sodium channel
ASICs Tooltip Acid-sensing ion channel
Chloride
CaCCs Tooltip Calcium-activated chloride channel
CFTR Tooltip Cystic fibrosis transmembrane conductance regulator
Unsorted
Others
TRPs Tooltip Transient receptor potential channels
LGICs Tooltip Ligand gated ion channels