From Wikipedia, the free encyclopedia
Analgesic drug under development
Funapide (
INN) (former developmental code names TV-45070 and XEN402) is a novel
analgesic under development by
Xenon Pharmaceuticals (formerly in partnership with
Teva Pharmaceutical Industries) for the treatment of a variety of
chronic pain conditions, including
osteoarthritis,
neuropathic pain,
postherpetic neuralgia, and
erythromelalgia, as well as
dental pain.
[1]
[2]
[3]
[4] It acts as a
small-molecule
Nav1.7 and
Nav1.8
voltage-gated sodium channel
blocker.
[1]
[2]
[4] Funapide is being evaluated in humans in both
oral and
topical formulations, and as of July 2014, has reached
phase IIb
clinical trials.
[1]
[3]
See also
References
- ^
a
b
c Bagal SK, Chapman ML, Marron BE, Prime R, Storer RI, Swain NA (August 2014).
"Recent progress in sodium channel modulators for pain". Bioorganic & Medicinal Chemistry Letters. 24 (16): 3690–3699.
doi:
10.1016/j.bmcl.2014.06.038.
PMID
25060923.
- ^
a
b Ali Z, Palmer JE,
Goli V (2013). "Anticonvulsants: Clinical". In McMahon S, Koltzenburg M, Tracey I, Turk DC (eds.).
Wall & Melzack's Textbook of Pain (6 ed.). Elsevier Health Sciences. p. 508.
ISBN
978-0-7020-4059-7.
OCLC
1008841684.
- ^
a
b
"TV-45070: A Small Molecule for the Treatment of the Orphan Disease EM and Other Pain Disorders". Xenon Pharma. Archived from
the original on 15 July 2013.
- ^
a
b
"Teva and Xenon Announce Teva's World Wide License of Xenon's Pain Drug XEN402". Xenon Pharma. 11 December 2012. Archived from
the original on 26 July 2014. Retrieved 2014-07-20.
External links
|
---|
Calcium |
VDCCsTooltip Voltage-dependent calcium channels | |
---|
|
---|
Potassium |
VGKCsTooltip Voltage-gated potassium channels | |
---|
IRKsTooltip Inwardly rectifying potassium channel | |
---|
KCaTooltip Calcium-activated potassium channel | |
---|
K2PsTooltip Tandem pore domain potassium channel | |
---|
|
---|
Sodium |
VGSCsTooltip Voltage-gated sodium channels | |
---|
ENaCTooltip Epithelial sodium channel | |
---|
ASICsTooltip Acid-sensing ion channel | |
---|
|
---|
Chloride |
CaCCsTooltip Calcium-activated chloride channel | |
---|
CFTRTooltip Cystic fibrosis transmembrane conductance regulator | |
---|
Unsorted | |
---|
|
---|
Others |
TRPsTooltip Transient receptor potential channels | |
---|
LGICsTooltip Ligand gated ion channels | |
---|
|
---|
|