Z4349 is an
opioid analgesic drug developed in the 1990s by the pharmaceutical company
Zambon. It is a derivative of an older drug
viminol, which has been modified to improve potency and metabolic stability. In tests on mice it was found to be several hundred times the potency of
morphine.[1][2]
^US 4960788, Carenzi A, Chiarino D, Bella DD, Grancini GC, Veneziani C, "Pyrrolidone-2 compounds and their use for central analgesic activity", issued 2 October 1990, assigned to Zambon Group S.P.A.
^Napoletano M, Delia BD, Fraire C, Grancini G, Masotto C, Ricciardi S, Zambon C (1995). "Stereoselective synthesis and evaluation of all stereoisomers of Z4349, a novel and selective μ-opioid analgesic". Bioorganic & Medicinal Chemistry Letters. 5 (6): 589–592.
doi:
10.1016/0960-894X(95)00077-7.