Names | |
---|---|
IUPAC name
L-Valyl-L-valyl-L-tyrosyl-L-prolyl-L-tryptophyl-L-threonyl-L-glutamine
| |
Identifiers | |
3D model (
JSmol)
|
|
ChemSpider | |
PubChem
CID
|
|
| |
| |
Properties | |
C44H61N9O11 | |
Molar mass | 892.024 g·mol−1 |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Valorphin, also known as VV-hemorphin-5, is a naturally occurring, endogenous opioid heptapeptide of the hemorphin family with the amino acid sequence H-Val-Val-Tyr-Pro-Trp-Thr-Gln-OH (VVYPWTQ). [1] [2] [3] It is produced in the body via proteolyic cleavage of residues 33-39 of the β-chain of hemoglobin. [2] [4] Valorphin binds preferentially to the μ-opioid receptor and produces effects such as analgesia and self-administration in animals. [1] [2] It also possesses cytotoxic and antiproliferative properties against tumor cells, [3] [4] [5] [6] the mediation of which, because they are reversed by naloxone, appears to be dependent on the opioid receptors. [5]