LS-115509 is an
opioidanalgesic related to the
4-phenylpiperidine family. It is comparable to drugs such as
prodine and
pheneridine, but is distinguished by the presence of an
ether group and
furan ring at the piperidine 4-position, which are not found in other drugs of this class. In animal studies, it has around 2-3x the potency of
morphine depending on what assay is used. Like prodine, it has two stereocenters and four possible
enantiomers, but the activity of these has not been tested separately.[1][2][3]
^Casy AF, Beckett AH, Hall GH, Vallance DK (December 1961). "Chemistry and pharmacology of 4-alkoxy-piperidines related to reversed esters of pethidine". Journal of Medicinal and Pharmaceutical Chemistry. 4 (3): 535–51.
doi:
10.1021/jm50019a012.
PMID13877295.
^Beckett AH, Casy AF (February 1965). "Analgesics and their antagonists: biochemical aspects and structure-activity relationships". Progress in Medicinal Chemistry. 4: 171–218.
doi:
10.1016/s0079-6468(08)70169-3.
ISBN9780444533234.
PMID5319798.
^Lenz GR, Evans SM, Walters DE, Hopfinger AJ (1986). Opiates. Orlando: Academic Press. p. 337.
ISBN978-0-12-443830-9.