From Wikipedia, the free encyclopedia
Chemical compound
Chlornaltrexamine
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Names
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IUPAC name
6β-[Bis(2-chloroethyl)amino]-17-(cyclopropylmethyl)-4,5α-epoxymorphinan-3,14-diol
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Systematic IUPAC name
(4R,4aS,7R,7aR,12bS)-7-[Bis(2-chloroethyl)amino]-3-(cyclopropylmethyl)-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methano[1]benzofuro[3,2-e]isoquinoline-4a,9-diol
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Other names
α-Chlornaltrexamine
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Identifiers
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ChemSpider
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InChI=1S/C24H32Cl2N2O3/c25-8-11-27(12-9-26)17-5-6-24(30)19-13-16-3-4-18(29)21-20(16)23(24,22(17)31-21)7-10-28(19)14-15-1-2-15/h3-4,15,17,19,22,29-30H,1-2,5-14H2/t17-,19-,22+,23+,24-/m1/s1 NKey: OSLQQDMGHVQLCH-HRMPSQMFSA-N NInChI=1/C24H32Cl2N2O3/c25-8-11-27(12-9-26)17-5-6-24(30)19-13-16-3-4-18(29)21-20(16)23(24,22(17)31-21)7-10-28(19)14-15-1-2-15/h3-4,15,17,19,22,29-30H,1-2,5-14H2/t17-,19-,22+,23+,24-/m1/s1 Key: OSLQQDMGHVQLCH-HRMPSQMFBW
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O[C@@]13[C@]2([C@@H]5[C@H](N(CCCl)CCCl)CC3)C4=C(C=CC(O)=C4O5)C[C@H]1N(CC6CC6)CC2
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Properties
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C24H32Cl2N2O3
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Molar mass
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467.43 g·mol−1
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Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Chlornaltrexamine is an irreversible mixed
agonist–antagonist for
μ-
opioid
receptors, which forms a
covalent bond to the
binding site. It is 22 times more potent than morphine. Its alkylating group is a bis(chloroalkyl)amino-residue similar to that of the
nitrogen mustards.
[1]
[2]
[3]
[4]
[5]
[6]
See also
References
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^
Portoghese PS, Larson DL, Jiang JB, Takemori AE, Caruso TP (July 1978). "6β-[N,N-Bis(2-chloroethyl)amino]-17-(cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan(chlornaltrexamine) a potent opioid receptor alkylating agent with ultralong narcotic antagonist activity". J. Med. Chem. 21 (7): 598–9.
doi:
10.1021/jm00205a002.
PMID
209185.
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^ Portoghese PS, Larson DL, Jiang JB, Caruso TP, Takemori AE (February 1979). "Synthesis and pharmacologic characterization of an alkylating analogue (chlornaltrexamine) of naltrexone with ultralong-lasting narcotic antagonist properties". J. Med. Chem. 22 (2): 168–73.
doi:
10.1021/jm00188a008.
PMID
218009.
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^ Caruso TP, Takemori AE, Larson DL, Portoghese PS (April 1979). "Chloroxymorphamine, and opioid receptor site-directed alkylating agent having narcotic agonist activity". Science. 204 (4390): 316–8.
Bibcode:
1979Sci...204..316C.
doi:
10.1126/science.86208.
PMID
86208.
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^ Caruso TP, Larson DL, Portoghese PS, Takemori AE (June 1980).
"Pharmacological studies with an alkylating narcotic agonist, chloroxymorphamine, and antagonist, chlornaltrexamine". J. Pharmacol. Exp. Ther. 213 (3): 539–44.
PMID
6162947.
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^ Caruso TP, Larson DL, Portoghese PS, Takemori AE (December 1980). "Isolation of selective 3H-chlornaltrexamine-bound complexes, possible opioid receptor components in brains of mice". Life Sci. 27 (22): 2063–9.
doi:
10.1016/0024-3205(80)90485-3.
PMID
6259471.
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^ Sayre LM, Takemori AE, Portoghese PS (1983). "Alkylation of opioid receptor subtypes by α-chlornaltrexamine produces concurrent irreversible agonistic and irreversible antagonistic activities". J. Med. Chem. 26 (4): 503–6.
doi:
10.1021/jm00358a009.
PMID
6300401.