Charles V, Holy Roman Emperor
|Reign||28 June 1519 – 3 August 1556|
|King of Spain ( Castile and Aragon)|
|Reign||14 March 1516 – 16 January 1556|
|Co-monarch||Joanna (until 1555, de jure)|
|Archduke of Austria|
|Reign||12 January 1519 – 21 April 1521|
|Successor||Ferdinand I (in the name of Charles V until 1556)|
|Lord of the Netherlands|
|Reign||25 September 1506 – 25 October 1555|
|Predecessor||Philip I of Castile|
|Successor||Philip II of Spain|
|Born||24 February 1500|
Prinsenhof of Ghent, Flanders, Burgundian Low Countries
|Died||21 September 1558 (aged 58)|
Monastery of Yuste, Crown of Castile, Spain
|Burial||22 September 1558|
El Escorial, Spain
( m. 1526; died 1539)
|Father||Philip I of Castile|
|Mother||Joanna of Castile|
Charles V [a] (24 February 1500 – 21 September 1558) was Holy Roman Emperor and Archduke of Austria from 1519 to 1556, King of Spain ( Castile and Aragon) from 1516 to 1556, and Lord of the Netherlands as titular Duke of Burgundy from 1506 to 1555. As he was head of the rising House of Habsburg during the first half of the 16th century, his dominions in Europe included the Holy Roman Empire, extending from Germany to northern Italy with direct rule over the Austrian hereditary lands and the Burgundian Low Countries, and a unified Spain with its southern Italian kingdoms of Naples, Sicily, and Sardinia. Furthermore, his reign encompassed both the long-lasting Spanish and the short-lived German colonizations of the Americas. The personal union of the European and American territories of Charles V was the first collection of realms labelled " the empire on which the Sun never sets". 
Charles was born in the County of Flanders to Philip the Handsome of the Austrian House of Habsburg (son of Maximilian I, Holy Roman Emperor, and Mary of Burgundy) and Joanna the Mad of the Spanish House of Trastámara (daughter of Isabella I of Castile and Ferdinand II of Aragon). The ultimate heir of his four grandparents, he inherited all of his family dominions at a young age, due to the premature death of his father and the mental illness of his mother. After the death of Philip in 1506, he inherited the Burgundian Netherlands, originally held by his paternal grandmother Mary.  In 1516, he became co-monarch of Spain with his mother Joanna, and as such he was the first king of Spain to inherit the country as dynastically unified by the Catholic Monarchs, his maternal grandparents.  The Spanish possessions at his accession also included the Castilian West Indies and the Aragonese Kingdoms of Naples, Sicily and Sardinia. At the death of his paternal grandfather Maximilian in 1519, he inherited Austria and was elected to succeed him as Holy Roman Emperor. He adopted the Imperial name of Charles V as his main title, and styled himself as a new Charlemagne. 
Charles V revitalized the medieval concept of the universal monarchy and spent most of his life defending the integrity of the Holy Roman Empire from the Protestant Reformation, the expansion of the Ottoman Empire, and a series of wars with France.  With no fixed capital city, he made 40 journeys, travelling from country to country; he spent a quarter of his reign on the road.  The imperial wars were fought by German Landsknechte, Spanish tercios, Burgundian knights, and Italian condottieri. Charles V borrowed money from German and Italian bankers and, in order to repay such loans, he relied on the proto-capitalist economy of the Low Countries and on the flows of gold and especially silver from South America to Spain, which caused widespread inflation. He ratified the Spanish conquest of the Aztec and Inca empires by the Spanish Conquistadores Hernán Cortés and Francisco Pizarro, as well as the establishment of Klein-Venedig by the German Welser family in search of the legendary El Dorado. In order to consolidate power in his early reign, Charles suppressed two Spanish insurrections ( Comuneros' Revolt and Brotherhoods' Revolt) and two German rebellions ( Knights' Revolt and Great Peasants' Revolt).
Crowned King in Germany, Charles sided with Pope Leo X and declared Martin Luther an outlaw at the Diet of Worms (1521).  The same year Francis I of France, surrounded by the Habsburg possessions, started a conflict in Lombardy that lasted until the Battle of Pavia (1525) led to his temporary imprisonment. The Protestant affair re-emerged in 1527 as Rome was sacked by an army of Charles's mutinous soldiers, largely of Lutheran faith. After his forces left the Papal States, Charles V defended Vienna from the Turks and obtained the coronation as King in Italy by Pope Clement VII. In 1535, he annexed the vacant Duchy of Milan and captured Tunis. Nevertheless, the loss of Buda during the struggle for Hungary and the Algiers expedition in the early 40s frustrated his anti-Ottoman policies. Meanwhile, Charles V had come to an agreement with Pope Paul III for the organisation of the Council of Trent (1545). The refusal of the Lutheran Schmalkaldic League to recognize the council's validity led to a war, won by Charles V with the imprisonment of the Protestant princes. However, Henry II of France offered new support to the Lutheran cause and strengthened a close alliance with the sultan Suleiman the Magnificent, the ruler of the Ottoman Empire since 1520.
Ultimately, Charles V conceded the Peace of Augsburg and abandoned his multi-national project with a series of abdications in 1556 that divided his hereditary and imperial domains between the Spanish Habsburgs headed by his son Philip II of Spain and the Austrian Habsburgs headed by his brother Ferdinand, who was Archduke of Austria in Charles's name since 1521 and the designated successor as emperor since 1531.    The Duchy of Milan and the Habsburg Netherlands were left in personal union to the King of Spain, but remained part of the Holy Roman Empire. The two Habsburg dynasties remained allied until the extinction of the Spanish line in 1700. In 1557, Charles retired to the Monastery of Yuste in Extremadura and died there a year later.
You, noble prince Charles, are more blessed than Alexander the Great. He for his part had seized an immense empire, but not without bloodshed nor was it destined to endure...you were born to a splendid empire...you owe it to heaven that your empire came to you without the shedding of blood, and no one suffered for it. 
|Ancestors of Charles V, Holy Roman Emperor|
Charles of Habsburg was born on 24 February 1500 in the Prinsenhof of Ghent, a Flemish city of the Burgundian Low Countries, to Philip of Habsburg and Joanna of Trastámara.  His father Philip, nicknamed Philip the Handsome, was the firstborn son of Maximilian I of Habsburg, Archduke of Austria as well as Holy Roman Emperor, and Mary the Rich, Burgundian duchess of the Low Countries. His mother Joanna, known as Joanna the Mad for the mental disorders afflicting her, was a daughter of Ferdinand II of Aragon and Isabella I of Castile, the Catholic Monarchs of Spain from the House of Trastámara. The political marriage of Philip and Joanna was first conceived in a letter sent by Maximilian to Ferdinand in order to seal an Austro-Spanish alliance, established as part of the League of Venice directed against the Kingdom of France during the Italian Wars. 
The organization of ambitious political marriages reflected Maximilian's practice to expand the House of Habsburg with dynastic links rather than conquest, as exemplified by his saying "Let others wage war, you, happy Austria, marry". The marriage contract between Philip and Joanna was signed in 1495, and celebrations were held in 1496. Philip was already Duke of Burgundy, given Mary's death in 1482, and also heir apparent of Austria as honorific Archduke. Joanna, in contrast, was only third in the Spanish line of succession, preceded by her older brother John of Castile and older sister Isabella of Aragon. Although both John and Isabella died in 1498, the Catholic Monarchs desired to keep the Spanish kingdoms in Iberian hands and designated their Portuguese grandson Miguel da Paz as heir presumptive of Spain by naming him Prince of the Asturias. Only a series of dynastic accidents eventually favoured Maximilian's project. 
Charles was given birth in a bathroom of the Prinsenhof at 3:00 AM by Joanna not long after she attended a ball despite symptoms of labor pains, and his name was chosen by Philip in honour of Charles I of Burgundy. According to a poet at the court, the people of Ghent "shouted Austria and Burgundy throughout the whole city for three hours" to celebrate his birth.  Given the dynastic situation, the newborn was originally heir apparent only of the Burgundian Low Countries as the honorific Duke of Luxembourg and became known in his early years simply as Charles of Ghent. He was baptized at the Saint Bavo's Cathedral by the Bishop of Tournai: Charles I de Croÿ and John III of Glymes were his godfathers; Margaret of York and Margaret of Austria his godmothers. Charles's baptism gifts were a sword and a helmet, objects of Burgundian chivalric tradition representing, respectively, the instrument of war and the symbol of peace. 
In 1501, Philip and Joanna left Charles to the custody of his aunt Margaret of Austria, Duchess of Savoy and went to Spain. They returned to visit their son very rarely, and thus Charles grew up parentless in Mechelen together with his sisters Eleanora, Maria and Isabella at the Duchess's court. He received education from Willem II of Croÿ and Adrian of Utrecht. The main goal of their Spanish mission was the recognition of Joanna as Princess of Asturias, given prince Miguel's death a year earlier. They succeeded despite facing some opposition from the Spanish Cortes, reluctant to create the premises for Habsburg succession. In 1504, as Isabella passed away, Joanna became Queen of Castile. Philip was recognized King in 1506 but died shortly after, an event that drove the mentally unstable Joanna into complete insanity. She retired in isolation into a tower of Tordesillas. Ferdinand took control of all the Spanish kingdoms, under the pretext of protecting Charles's rights, which in reality he wanted to elude, but his new marriage with Germaine de Foix failed to produce a surviving Trastámara heir to the throne. With his father dead and his mother confined, Charles became Duke of Burgundy and was recognized as prince of Asturias (heir presumptive of Spain) and honorific archduke (heir apparent of Austria). 
The Burgundian inheritance included the Habsburg Netherlands, which consisted of a large number of the lordships that formed the Low Countries and covered modern-day Belgium, Holland and Luxembourg. It excluded Burgundy proper, annexed by France in 1477, with the exception of Franche-Comté. At the death of Philip in 1506, Charles was recognized Lord of the Netherlands with the title of Charles II of Burgundy. During Charles's childhood and teen years, William de Croÿ (later prime minister) and Adrian of Utrecht (later Pope Adrian VI) served as his tutors. The culture and courtly life of the Low Countries played an important part in the development of Charles's beliefs. As a member of the Burgundian Order of the Golden Fleece in his infancy, and later its grandmaster, Charles was educated to the ideals of the medieval knights and the desire for Christian unity to fight the infidel.  The Low Countries were very rich during his reign, both economically and culturally. Charles was very attached to his homeland and spent much of his life in Brussels.
The Spanish inheritance, resulting from a dynastic union of the crowns of Castile and Aragon, included Spain as well as the Castilian West Indies and the Aragonese Two Sicilies. Joanna inherited these territories in 1516 in a condition of mental illness. Charles, therefore, claimed the crowns for himself jure matris, thus becoming co-monarch of Joanna with the title of Charles I of Castile and Aragon or Charles I of Spain. Castile and Aragon together formed the largest of Charles's personal possessions, and they also provided a great number of generals and tercios (the formidable Spanish infantry of the time). However, at his accession to the throne, Charles was viewed as a foreign prince. Two rebellions, the revolt of the Germanies and the revolt of the comuneros, contested Charles's rule in the 1520s. Following these revolts, Charles placed Spanish counselors in a position of power and spent a considerable part of his life in Castile, including his final years in a monastery. Indeed, Charles's motto, Plus Ultra (Further Beyond), became the national motto of Spain and his heir, later Philip II, was born and raised in Castile. Nonetheless, many Spaniards believed that their resources (largely consisting of flows of silver from the Americas) were being used to sustain Imperial-Habsburg policies that were not in the country's interest. 
Charles inherited the Austrian hereditary lands in 1519, as Charles I of Austria, and obtained the election as Holy Roman Emperor against the candidacy of the French King. Since the Imperial election, he was known as Emperor Charles V even outside of Germany and the A.E.I.O.U. motto of the House of Austria acquired political significance. Despite the fact that he was elected as a German prince, Charles's staunch Catholicism in contrast to the growth of Lutheranism alienated him from various German princes who finally fought against him. Charles's presence in Germany was often marked by the organization of imperial diets to maintain religious unity. He was frequently in Northern Italy, often taking part in complicated negotiations with the Popes to address the rise of Protestantism. It is important to note, though, that the German Catholics supported the Emperor. Charles had a close relationship with important German families, like the House of Nassau, many of which were represented at his court in Brussels. Several German princes or noblemen accompanied him in his military campaigns against France or the Ottomans, and the bulk of his army was generally composed of German troops, especially the Imperial Landsknechte.  
It is said that Charles spoke several languages. He was fluent in French and Dutch, his native languages. He later added an acceptable Castilian Spanish, which he was required to learn by the Castilian Cortes Generales. He could also speak some Basque, acquired by the influence of the Basque secretaries serving in the royal court.  He gained a decent command of German following the Imperial election, though he never spoke it as well as French.  A witticism sometimes attributed to Charles is: "I speak Spanish/Latin (depending on the source) to God, Italian to women, French to men and German to my horse."  A variant of the quote is attributed to him by Swift in his 1726 Gulliver's Travels, but there are no contemporary accounts referencing the quotation (which has many other variants) and it is often attributed instead to Frederick the Great.  
Given the vast dominions of the House of Habsburg, Charles was often on the road and needed deputies to govern his realms for the times he was absent from his territories. His first Governor of the Netherlands was Margaret of Austria (succeeded by Mary of Hungary and Emmanuel Philibert, Duke of Savoy). His first Regent of Spain was Adrian of Utrecht (succeeded by Isabella of Portugal and Philip II of Spain). For the regency and governorship of the Austrian hereditary lands, Charles named his brother Ferdinand Archduke in the Austrian lands under his authority at the Diet of Worms (1521). Charles also agreed to favor the election of Ferdinand as King of the Romans in Germany, which took place in 1531. Therefore, it is by virtue of the Worms agreement that Ferdinand became Holy Roman Emperor and obtained hereditary rights over Austria at the abdication of Charles in 1556.  
Charles V made ten trips to the Low Countries, nine to German-speaking lands, seven to Spain, seven to Italian states, four to France, two to England, and two to North Africa.  During his travels, Charles V left a documentary trail in almost every place he went, allowing historians to surmise that he spent over 10,000 days in the Low Countries, 6,500 days in Spain, more than 3000 days in German-speaking territories, and almost 1,000 days in the Italian peninsula. He further spent 195 days in France, 99 in North Africa and 44 days in England. For only 260 days, his exact location is unrecorded, all of them being days spent at sea travelling between his dominions.  As he put it in his last public speech: "my life has been one long journey". 
In 1506, Charles inherited his father's Burgundian territories that included Franche-Comté and, most notably, the Low Countries. The latter territories lay within the Holy Roman Empire and its borders, but were formally divided between fiefs of the German kingdom and French fiefs such as Charles's birthplace of Flanders, a last remnant of what had been a powerful player in the Hundred Years' War. As he was a minor, his aunt Margaret of Austria (born as Archduchess of Austria and in both her marriages as the Dowager Princess of Asturias and Dowager Duchess of Savoy) acted as regent, as appointed by Emperor Maximilian until 1515. She soon found herself at war with France over Charles's requirement to pay homage to the French king for Flanders, as his father had done. The outcome was that France relinquished its ancient claim on Flanders in 1528.
From 1515 to 1523, Charles's government in the Netherlands also had to contend with the rebellion of Frisian peasants (led by Pier Gerlofs Donia and Wijard Jelckama). The rebels were initially successful but after a series of defeats, the remaining leaders were captured and decapitated in 1523.
Charles extended the Burgundian territory with the annexation of Tournai, Artois, Utrecht, Groningen, and Guelders. The Seventeen Provinces had been unified by Charles's Burgundian ancestors, but nominally were fiefs of either France or the Holy Roman Empire. In 1549, Charles issued a Pragmatic Sanction, declaring the Low Countries to be a unified entity of which his family would be the heirs. 
The Low Countries held an essential place in the Empire. For Charles V, they were his home, the region where he was born and spent his childhood. Because of trade and industry and the wealth of the region's cities, the Low Countries also represented a significant income for the Imperial treasury.
The Burgundian territories were generally loyal to Charles throughout his reign. The important city of Ghent rebelled in 1539 due to heavy tax payments demanded by Charles. The rebellion did not last long, however, as Charles's military response, with reinforcement from the Duke of Alba,  was swift and humiliating to the rebels of Ghent.  
In the Castilian Cortes of Valladolid in 1506 and of Madrid in 1510, Charles was sworn as the Prince of Asturias, heir-apparent to his mother the Queen Joanna.  On the other hand, in 1502, the Aragonese Corts gathered in Saragossa and pledged an oath to Joanna as heiress-presumptive, but the Archbishop of Saragossa expressed firmly that this oath could not establish jurisprudence, that is to say, modify the right of the succession, except by virtue of a formal agreement between the Cortes and the King.   So, upon the death of King Ferdinand II of Aragon, on 23 January 1516, Joanna inherited the Crown of Aragon, which consisted of Aragon, Catalonia, Valencia, Naples, Sicily and Sardinia, while Charles became governor general.  Nevertheless, the Flemings wished Charles to assume the royal title,[ citation needed] and this was supported by his grandfather the emperor Maximilian I and Pope Leo X.
Thus, after the celebration of Ferdinand II's obsequies on 14 March 1516, Charles was proclaimed king of the crowns of Castile and Aragon jointly with his mother. Finally, when the Castilian regent Cardinal Jiménez de Cisneros accepted the fait accompli, he acceded to Charles's desire to be proclaimed king and imposed his enstatement throughout the kingdom.  Charles arrived in his new kingdoms in autumn of 1517. Jiménez de Cisneros came to meet him but fell ill along the way, not without a suspicion of poison, and he died before reaching the King. 
Due to the irregularity of Charles assuming the royal title while his mother, the legitimate queen, was alive, the negotiations with the Castilian Cortes in Valladolid (1518) proved difficult.  In the end Charles was accepted under the following conditions: he would learn to speak Castilian; he would not appoint foreigners; he was prohibited from taking precious metals from Castile beyond the Quinto Real; and he would respect the rights of his mother, Queen Joanna. The Cortes paid homage to him in Valladolid in February 1518. After this, Charles departed to the crown of Aragon. He managed to overcome the resistance of the Aragonese Cortes and Catalan Corts,  and he was finally recognized as king of Aragon and count of Barcelona jointly with his mother.  The Kingdom of Navarre had been invaded by Ferdinand of Aragon jointly with Castile in 1512, but he pledged a formal oath to respect the kingdom. On Charles's accession to the Spanish thrones, the Parliament of Navarre (Cortes) required him to attend the coronation ceremony (to become Charles IV of Navarre). Still, this demand fell on deaf ears, and the Parliament kept piling up grievances.
Charles was accepted as sovereign, even though the Spanish felt uneasy with the Imperial style. Spanish kingdoms varied in their traditions. Castile had become an authoritarian, highly centralized kingdom, where the monarchs own will easily overrode legislative and justice institutions.  By contrast, in the crown of Aragon, and especially in the Pyrenean kingdom of Navarre, law prevailed, and the monarchy was seen as a contract with the people.  This became an inconvenience and a matter of dispute for Charles V and later kings since realm-specific traditions limited their absolute power. With Charles, the government became more absolute, even though until his mother died in 1555, Charles did not hold the full kingship of the country.
Soon resistance to the Emperor arose because of heavy taxation to support foreign wars in which Castilians had little interest and because Charles tended to select Flemings for high offices in Castile and America, ignoring Castilian candidates. The resistance culminated in the Revolt of the Comuneros, which Charles suppressed. Immediately after crushing the Castilian revolt, Charles was confronted again with the hot issue of Navarre when King Henry II attempted to reconquer the kingdom. Main military operations lasted until 1524, when Hondarribia surrendered to Charles's forces, but frequent cross-border clashes in the western Pyrenees only stopped in 1528 (Treaties of Madrid and Cambrai).
After these events, Navarre remained a matter of domestic and international litigation still for a century (a French dynastic claim to the throne did not end until the July Revolution in 1830). Charles wanted his son and heir Philip II to marry the heiress of Navarre, Jeanne d'Albret. Jeanne was instead forced to marry William, Duke of Julich-Cleves-Berg, but that childless marriage was annulled after four years. She next married Antoine de Bourbon, and both she and their son would oppose Philip II in the French Wars of Religion.
After its integration into Charles's empire, Castile guaranteed effective military units and its American possessions provided the bulk of the empire's financial resources. However, the two conflicting strategies of Charles V, enhancing the possessions of his family and protecting Catholicism against Protestants heretics, diverted resources away from building up the Spanish economy. Elite elements in Spain called for more protection for the commercial networks, which were threatened by the Ottoman Empire. Charles instead focused on defeating Protestantism in Germany and the Netherlands, which proved to be lost causes. Each hastened the economic decline of the Spanish Empire in the next generation.  The enormous budget deficit accumulated during Charles's reign, along with the inflation that affected the kingdom, resulted in declaring bankruptcy during the reign of Philip II. 
The Crown of Aragon inherited by Charles included the Kingdom of Naples, the Kingdom of Sicily and the Kingdom of Sardinia. As Holy Roman Emperor, Charles was sovereign in several states of northern Italy and had a claim to the Iron Crown (obtained in 1530). The Duchy of Milan, however, was under French control. France took Milan from the House of Sforza after victory against Switzerland at the Battle of Marignano in 1515. Imperial-Papal troops succeeded in re-installing the Sforza in Milan in 1521, in the context of an alliance between Charles V and Pope Leo X. A Franco-Swiss army was finally expelled from Lombardy at Bicocca a year later. Yet in 1524, Francis I of France retook the initiative, crossing into Lombardy where Milan, along with several other cities, once again fell to his attack. Pavia alone held out, and on 24 February 1525 (Charles's twenty-fifth birthday), Charles's forces led by Charles de Lannoy captured Francis and crushed his army in the Battle of Pavia. In 1535, Francesco II Sforza died without heirs and Charles V annexed the territory as a vacant Imperial state with the help of Massimiliano Stampa, one of the most influential courtiers of the late Duke.  Charles successfully held on to all of its Italian territories, though they were invaded again on multiple occasions during the Italian Wars.
In addition, Habsburg trade in the Mediterranean was consistently disrupted by the Ottoman Empire. In 1538 a Holy League consisting of all the Italian states and the Spanish kingdoms was formed to drive the Ottomans back, but it was defeated at the Battle of Preveza. Decisive naval victory eluded Charles; it would not be achieved until after Charles's death, at the Battle of Lepanto in 1571.
During Charles's reign, the Castilian territories in the Americas were considerably extended by conquistadores like Hernán Cortés and Francisco Pizarro. They conquered the large Aztec and Inca empires and incorporated them into the Empire as the Viceroyalties of New Spain and Peru between 1519 and 1542. Combined with the circumnavigation of the globe by the Magellan expedition in 1522, these successes convinced Charles of his divine mission to become the leader of Christendom, which still perceived a significant threat from Islam. The conquests also helped solidify Charles's rule by providing the state treasury with enormous amounts of bullion. As the conquistador Bernal Díaz del Castillo observed, "We came to serve God and his Majesty, to give light to those in darkness, and also to acquire that wealth which most men covet."  Charles used the Spanish feudal system as a model for labor relations in the new colonies. The local Spaniards strongly objected because it assumed the equality of Indians and Spaniards. The locals wanted complete control over labor and got it under Philip II in the 1570s. 
On 28 August 1518, Charles issued a charter authorizing the transportation of slaves direct from Africa to the Americas. Up until that point (since at least 1510), African slaves had usually been transported to Castile or Portugal and had then been transhipped to the Caribbean. Charles's decision to create a direct, more economically viable Africa to America slave trade fundamentally changed the nature and scale of the transatlantic slave trade. 
In 1528 Charles assigned a concession in Venezuela Province to Bartholomeus V. Welser, in compensation for his inability to repay debts owed. The concession, known as Klein-Venedig (little Venice), was revoked in 1546. In 1550, Charles convened a conference at Valladolid in order to consider the morality of the force  used against the indigenous populations of the New World, which included figures such as Bartolomé de las Casas.
Charles V is credited with the first idea of constructing an American Isthmus canal in Panama as early as 1520. 
After the death of his paternal grandfather, Maximilian, in 1519, Charles inherited the Habsburg Monarchy. He was also the natural candidate of the electors to succeed his grandfather as Holy Roman Emperor. After having paid huge bribes to the electors, he defeated the candidacies of Frederick III of Saxony, Francis I of France, and Henry VIII of England. Charles was the highest bidder and won the crown on 28 June 1519. On 26 October 1520 he was crowned in Germany and some ten years later, on 22 February 1530, he was crowned Holy Roman Emperor by Pope Clement VII in Bologna, the last emperor to receive a papal coronation.  
Despite his holding the imperial throne, Charles's real authority was limited by the German princes. They gained a strong foothold in the Empire's territories, and Charles was determined not to let this happen in the Netherlands. An inquisition was established as early as 1522. In 1550, the death penalty was introduced for all cases of unrepentant heresy. Political dissent was also firmly controlled, most notably in his place of birth, where Charles, assisted by the Duke of Alba, personally suppressed the Revolt of Ghent in mid-February 1540. 
Charles abdicated as emperor in 1556 in favour of his brother Ferdinand; however, due to lengthy debate and bureaucratic procedure, the Imperial Diet did not accept the abdication (and thus make it legally valid) until 24 February 1558. Up to that date, Charles continued to use the title of emperor.
Much of Charles's reign was taken up by conflicts with France, which found itself encircled by Charles's empire while it still maintained ambitions in Italy. In 1520, Charles visited England, where his aunt, Catherine of Aragon, urged her husband, Henry VIII, to ally himself with the emperor. In 1508 Charles was nominated by Henry VII to the Order of the Garter.  His Garter stall plate survives in Saint George's Chapel.
The first war with Charles's great nemesis Francis I of France began in 1521. Charles allied with England and Pope Leo X against the French and the Venetians, and was highly successful, driving the French out of Milan and defeating and capturing Francis at the Battle of Pavia in 1525.  To gain his freedom, Francis ceded Burgundy to Charles in the Treaty of Madrid, as well as renouncing his support of Henry II's claim over Navarre.
When he was released, however, Francis had the Parliament of Paris denounce the treaty because it had been signed under duress. France then joined the League of Cognac that Pope Clement VII had formed with Henry VIII of England, the Venetians, the Florentines, and the Milanese to resist imperial domination of Italy. In the ensuing war, Charles's sack of Rome (1527) and virtual imprisonment of Pope Clement VII in 1527 prevented the Pope from annulling the marriage of Henry VIII of England and Charles's aunt Catherine of Aragon, so Henry eventually broke with Rome, thus leading to the English Reformation.   In other respects, the war was inconclusive. In the Treaty of Cambrai (1529), called the "Ladies' Peace" because it was negotiated between Charles's aunt and Francis' mother, Francis renounced his claims in Italy but retained control of Burgundy.
A third war erupted in 1536. Following the death of the last Sforza Duke of Milan, Charles installed his son Philip in the duchy, despite Francis' claims on it. This war too was inconclusive. Francis failed to conquer Milan, but he succeeded in conquering most of the lands of Charles's ally, the Duke of Savoy, including his capital Turin. A truce at Nice in 1538 on the basis of uti possidetis ended the war but lasted only a short time. War resumed in 1542, with Francis now allied with Ottoman Sultan Suleiman I and Charles once again allied with Henry VIII. Despite the conquest of Nice by a Franco-Ottoman fleet, the French could not advance toward Milan, while a joint Anglo-Imperial invasion of northern France, led by Charles himself, won some successes but was ultimately abandoned, leading to another peace and restoration of the status quo ante bellum in 1544.
A final war erupted with Francis' son and successor, Henry II, in 1551. Henry won early success in Lorraine, where he captured Metz, but French offensives in Italy failed. Charles abdicated midway through this conflict, leaving further conduct of the war to his son, Philip II, and his brother, Ferdinand I, Holy Roman Emperor.
Charles fought continually with the Ottoman Empire and its sultan, Suleiman the Magnificent. The defeat of Hungary at the Battle of Mohács in 1526 "sent a wave of terror over Europe."   The Muslim advance in Central Europe was halted at the Siege of Vienna in 1529, followed by a counter-attack of Charles V across the Danube river. However, by 1541, central and southern Hungary fell under Turkish control.
Suleiman won the contest for mastery of the Mediterranean, in spite of Christian victories such as the conquest of Tunis in 1535.  The regular Ottoman fleet came to dominate the Eastern Mediterranean after its victories at Preveza in 1538 and Djerba in 1560 (shortly after Charles's death), which severely decimated the Spanish marine arm. At the same time, the Muslim Barbary corsairs, acting under the general authority and supervision of the sultan, regularly devastated the Spanish and Italian coasts, crippling Spanish trade and chipping at the foundations of Habsburg power.
In 1536 Francis I allied France with Suleiman against Charles. While Francis was persuaded to sign a peace treaty in 1538, he again allied himself with the Ottomans in 1542 in a Franco-Ottoman alliance. In 1543 Charles allied himself with Henry VIII and forced Francis to sign the Truce of Crépy-en-Laonnois. Later, in 1547, Charles signed a humiliating  treaty with the Ottomans to gain himself some respite from the huge expenses of their war. 
Charles V made overtures to the Safavid Empire to open a second front against the Ottomans, in an attempt at creating a Habsburg-Persian alliance. Contacts were positive, but rendered difficult by enormous distances. In effect, however, the Safavids did enter in conflict with the Ottoman Empire in the Ottoman-Safavid War, forcing it to split its military resources. 
The issue of the Protestant Reformation was first brought to the imperial attention under Charles V. As Holy Roman Emperor, Charles called Martin Luther to the Diet of Worms in 1521, promising him safe conduct if he would appear. After Luther defended the Ninety-five Theses and his writings, the Emperor commented: "that monk will never make me a heretic". Charles V relied on religious unity to govern his various realms, otherwise unified only in his person, and perceived Luther's teachings as a disruptive form of heresy. He outlawed Luther and issued the Edict of Worms, declaring:
You know that I am a descendant of the Most Christian Emperors of the great German people, of the Catholic Kings of Spain, of the Archdukes of Austria, and of the Dukes of Burgundy. All of these, their whole life long, were faithful sons of the Roman Church…After their deaths they left, by natural law and heritage, these holy catholic rites, for us to live and die by, following their example. And so until now I have lived as a true follower of these our ancestors. I am therefore resolved to maintain everything which these my forebears have established to the present.
Nonetheless, Charles V kept his word and left Martin Luther free to leave the city. Frederick the Wise, elector of Saxony and protector of Luther, lamented the outcome of the Diet. On the road back from Worms, Luther was kidnapped by Frederick's men and hidden in a distant castle in Wartburg. There, he began to work on his German translation of the bible. The spread of Lutheranism led to two major revolts: that of the knights in 1522–1523 and that of the peasants led by Thomas Muntzer in 1524–1525. While the pro-Imperial Swabian League, in conjunction with Protestant princes afraid of social revolts, restored order, Charles V used the instrument of pardon to maintain peace.
Thereafter, Charles V took a tolerant approach and pursued a policy of reconciliation with the Lutherans. At the 1530 Imperial Diet of Augsburg was requested by Emperor Charles V to decide on three issues: first, the defense of the Empire against the Ottoman threat; second, issues related to policy, currency and public well-being; and, third, disagreements about Christianity, in attempt to reach some compromise and a chance to deal with the German situation.  The Diet was inaugurated by the emperor on June 20. It produced numerous outcomes, most notably the 1530 declaration of the Lutheran estates known as the Augsburg Confession (Confessio Augustana), a central document of Lutheranism that was presented to the emperor. Luther's assistant Philip Melanchthon went even further and presented to Charles V the Lutheran Augsburg confession. The emperor strongly rejected it, and in 1531 the Schmalkaldic League was formed by Protestant princes. In 1532, Charles V recognized the League and effectively suspended the Edict of Worms with the standstill of Nuremberg. The standstill required the Protestants to continue to take part in the Imperial wars against the Turks and the French, and postponed religious affairs until an ecumenical council of the Catholic Church was called by the Pope to solve the issue.
Due to Papal delays in organizing a general council, Charles V decided to organize a German summit and presided over the Regensburg talks between Catholics and Lutherans in 1541, but no compromise was achieved. In 1545, the Council of Trent was finally opened and the Counter-Reformation began. The Catholic initiative was supported by a number of the princes of the Holy Roman Empire. However, the Schmalkaldic League refused to recognize the validity of the council and occupied territories of Catholic princes.  Therefore, Charles V outlawed the Schmalkaldic League and opened hostilities against it in 1546.  The next year his forces drove the League's troops out of southern Germany, and defeated John Frederick, Elector of Saxony, and Philip of Hesse at the Battle of Mühlberg, capturing both. At the Augsburg Interim in 1548, he created a solution giving certain allowances to Protestants until the Council of Trent would restore unity. However, members of both sides resented the Interim and some actively opposed it.
The council was re-opened in 1550 with the participation of Lutherans, and Charles V set up the Imperial court in Innsbruck, Austria, sufficiently close to Trent for him to follow the evolution of the debates. In 1552 Protestant princes, in alliance with Henry II of France, rebelled again and the second Schmalkaldic War began. Maurice of Saxony, instrumental for the Imperial victory in the first conflict, switched side to the Protestant cause and bypassed the Imperial army by marching directly into Innsbruck with the goal of capturing the Emperor. Charles V was forced to flee the city during an attack of gout and barely made it alive to Villach in a state of semi-consciousness carried in a litter. After failing to recapture Metz from the French, Charles V returned to the Low Countries for the last years of his emperorship. In 1555, he instructed his brother Ferdinand to sign the Peace of Augsburg in his name. The agreements led to the religious division of Germany between Catholic and Protestant princedoms. 
During his lifetime, Charles V had several mistresses, his step-grandmother, Germaine de Foix among them. These liaisons occurred during his bachelorhood and only once during his widowerhood; there are no records of his having any extramarital affairs during his marriage.
On 21 December 1507, Charles was betrothed to 11-year-old Mary, the daughter of King Henry VII of England and younger sister to the future King Henry VIII of England, who was to take the throne in two years. However, the engagement was called off in 1513, on the advice of Thomas Wolsey, and Mary was instead married to King Louis XII of France in 1514.
After his ascension to the Spanish thrones, negotiations for Charles's marriage began shortly after his arrival in Castile, with the Castilian nobles expressing their wishes for him to marry his first cousin Isabella of Portugal, the daughter of King Manuel I of Portugal and Charles's aunt Maria of Aragon. The nobles desired Charles's marriage to a princess of Castilian blood, and a marriage to Isabella would have secured an alliance between Castile and Portugal. However, the 18-year-old King was in no hurry to marry and ignored the nobles' advice, exploring other marriage options.  Instead of marrying Isabella, he sent his sister Eleanor to marry Isabella's widowed father, King Manuel, in 1518.
In 1521, on the advice of his Flemish counselors, especially William de Croÿ, Charles became engaged to his other first cousin, Mary, daughter of his aunt, Catherine of Aragon, and King Henry VIII, in order to secure an alliance with England. However, this engagement was very problematic because Mary was only 6 years old at the time, sixteen years Charles's junior, which meant that he would have to wait for her to be old enough to marry.
By 1525, Charles was no longer interested in an alliance with England and could not wait any longer to have legitimate children and heirs. Following his victory in the Battle of Pavia, Charles abandoned the idea of an English alliance, cancelled his engagement to Mary and decided to marry Isabella and form an alliance with Portugal. He wrote to Isabella's brother, King John III of Portugal, making a double marriage contract – Charles would marry Isabella and John would marry Charles's youngest sister, Catherine. A marriage to Isabella was more beneficial for Charles, as she was closer to him in age, was fluent in Spanish and provided him with a very handsome dowry of 900,000 Portuguese cruzados or Castilian folds that would help to solve the financial problems brought on by the Italian Wars.
On 10 March 1526, Charles and Isabella met at the Alcázar Palace in Seville. The marriage was originally a political arrangement, but on their first meeting, the couple fell deeply in love: Isabella captivated the Emperor with her beauty and charm. They were married that very same night in a quiet ceremony in the Hall of Ambassadors, just after midnight. Following their wedding, Charles and Isabella spent a long and happy honeymoon at the Alhambra in Granada. Charles began the construction of the Palace of Charles V in 1527, wishing to establish a permanent residence befitting an emperor and empress in the Alhambra palaces. However, the palace was not completed during their lifetimes and remained roofless until the late 20th century. 
Despite the Emperor's long absences due to political affairs abroad, the marriage was a happy one, as both partners were always devoted and faithful to each other.  The Empress acted as regent of Spain during her husband's absences, and she proved herself to be a good politician and ruler, thoroughly impressing the Emperor with many of her political accomplishments and decisions.
The marriage lasted for thirteen years, until Isabella's death in 1539. The Empress contracted a fever during the third month of her seventh pregnancy, which resulted in antenatal complications that caused her to miscarry a stillborn son. Her health further deteriorated due to an infection, and she died two weeks later on 1 May 1539, aged 35. Charles was left so grief-stricken by his wife's death that for two months he shut himself up in a monastery, where he prayed and mourned for her in solitude.  Charles never recovered from Isabella's death, dressing in black for the rest of his life to show his eternal mourning, and, unlike most kings of the time, he never remarried. In memory of his wife, the Emperor commissioned the painter Titian to paint several posthumous portraits of Isabella; the finished portraits included Titian's Portrait of Empress Isabel of Portugal and La Gloria.  Charles kept these paintings with him whenever he travelled, and they were among those that he brought with him after his retirement to the Monastery of Yuste in 1557. 
In 1540, Charles paid tribute to Isabella's memory when he commissioned the Flemish composer Thomas Crecquillon to compose new music as a memorial to her. Crecquillon composed his Missa 'Mort m'a privé in memory of the Empress. It expresses the Emperor's grief and great wish for a heavenly reunion with his beloved wife. 
Charles suffered from an enlarged lower jaw, a congenital deformity that became considerably worse in later Habsburg generations, giving rise to the term Habsburg jaw. This deformity may have been caused by the family's long history of inbreeding, the consequence of repeated marriages between close family members, as commonly practiced in royal families of that era to maintain dynastic control of territory.  He suffered from epilepsy  and was seriously afflicted with gout, presumably caused by a diet consisting mainly of red meat.  As he aged, his gout progressed from painful to crippling. In his retirement, he was carried around the monastery of St. Yuste in a sedan chair. A ramp was specially constructed to allow him easy access to his rooms. 
Between 1554 and 1556, Charles V gradually divided the Habsburg empire between a Spanish line and a German-Austrian branch. His abdications occurred at the Palace of Coudenberg and are therefore known as "Abdications of Brussels" (Abdankung von Brüssel in German and Abdicación de Bruselas in Spanish). First he abdicated the thrones of Sicily and Naples, both fiefs of the Papacy, and the Imperial Duchy of Milan, in favour of his son Philip on 25 July 1554. Philip was secretly invested with Milan already in 1540 and again in 1546, but only in 1554 the Emperor made it public. Upon the abdications of Naples and Sicily, Philip was invested by Pope Julius III with the kingdom of Naples on 2 October and with the Kingdom of Sicily on 18 November. 
The most famous—and only public—abdication took place a year later, on 25 October 1555, when Charles announced to the States General of the Netherlands, reunited in the great hall of the palace where he was emancipated exactly forty years earlier, his abdication in favour of his son of those territories and his intention to step down from all of his positions and retire to a monastery.  This was the occasion for Charles V to pronounce his resignation speech:
When I was nineteen, upon the Emperor's death, I undertook to be a candidate for the Imperial crown, not to increase my possessions but rather to engage myself more vigorously in working for the welfare of Germany and my other realms and in the hopes of thereby bringing peace among the Christian peoples and uniting their fighting forces for the defense of the Catholic faith against the Ottomans. That's why I had to make a lot of arduous trips, had to wage a lot of arduous wars ... but never willfully, and always against my will as an attacked person ... I had great hopes – only a few have been fulfilled, and only a few remain to me: and at the cost of what effort! It ultimately made me tired and sick .... Do not think that I want to escape any troubles and dangers: my strength is simply not enough .... As for me: I know that I made many mistakes, big mistakes, first because of my youth, then because of human error and because of my passions, and finally because of tiredness. But I deliberately did no wrong to anyone, whoever it was. Should injustice have arisen, it happened without my knowledge and only out of inability: I publicly regret it and ask forgiveness to everyone who I might have offended. 
He concluded the speech by mentioning his voyages: ten to the Low Countries, nine to Germany, seven to Spain, seven to Italy, four to France, two to England, and two to North Africa. His last public words were: My life has been one long journey. With no fanfare, in 1556 he finalized his abdications. On 16 January 1556, he gave Spain and the Spanish Empire in the Americas to Philip. On 3 August 1556, he abdicated as Holy Roman Emperor in favour of his brother Ferdinand, elected King of the Romans in 1531. The succession was recognized by the prince-electors assembled at Frankfurt only in 1558, and by the Pope only in 1559.    The Imperial abdication also marked the beginning of Ferdinand's legal and suo jure rule in the Austrian possessions, that he governed in Charles's name since 1521–1522 and were attached to Hungary and Bohemia since 1526. 
According to scholars, Charles decided to abdicate for a variety of reasons: the religious division of Germany sanctioned in 1555; the state of Spanish finances, bankrupted with inflation by the time his reign ended; the revival of Italian Wars with attacks from Henri II of France; the never-ending advance of the Ottomans in the Mediterranean and central Europe; and his declining health, in particular attacks of gout such as the one that forced him to postpone an attempt to recapture the city of Metz where he was later defeated.
In September 1556, Charles left the Low Countries and sailed to Spain accompanied by Mary of Hungary and Eleanor of Austria. He arrived at the Monastery of Yuste of Extremadura in 1557. He continued to correspond widely and kept an interest in the situation of the empire, while suffering from severe gout. He lived alone in a secluded monastery, surrounded by paintings by Titian and with clocks lining every wall, which some historians believe were symbols of his reign and his lack of time.  In an act designed to "merit the favour of heaven", about six months before his death Charles staged his own funeral, complete with shroud and coffin, after which he "rose out of the coffin, and withdrew to his apartment, full of those awful sentiments, which such a singular solemnity was calculated to inspire."  In August 1558, Charles was taken seriously ill with what was later revealed to be malaria.  He died in the early hours of the morning on 21 September 1558, at the age of 58, holding in his hand the cross that his wife Isabella had been holding when she died. 
Charles was originally buried in the chapel of the Monastery of Yuste, but he left a codicil in his last will and testament asking for the establishment of a new religious foundation in which he would be reburied with Isabella.  Following his return to Spain in 1559, their son Philip undertook the task of fulfilling his father's wish when he founded the Monastery of San Lorenzo de El Escorial. After the Monastery's Royal Crypt was completed in 1574, the bodies of Charles and Isabella were relocated and re-interred into a small vault in directly underneath the altar of the Royal Chapel, in accordance with Charles's wishes to be buried "half-body under the altar and half-body under the priest's feet" side by side with Isabella. They remained in the Royal Chapel while the famous Basilica of the Monastery and the Royal tombs were still under construction. In 1654, after the Basilica and Royal tombs were finally completed during the reign of their great-grandson Philip IV, the remains of Charles and Isabella were moved into the Royal Pantheon of Kings, which lies directly under the Basilica.  On one side of the Basilica are bronze effigies of Charles and Isabella, with effigies of their daughter Maria of Austria and Charles's sisters Eleanor of Austria and Maria of Hungary behind them. Exactly adjacent to them on the opposite side of the Basilica are effigies of their son Philip with three of his wives and their ill-fated grandson Carlos, Prince of Asturias.
Charles and Isabella had seven children, though only three survived to adulthood:
Philip II of Spain
||21 May 1527 –
13 September 1598
|Only surviving son, successor of his father in the Spanish crowns.|
||21 June 1528 –
26 February 1603
|Married her first cousin Maximilian II, Holy Roman Emperor.|
||22 November 1529 –
13 July 1530
|Died in infancy.|
||29 June 1534||Stillborn|
||26 June 1535 –
7 September 1573
|Married her first cousin João Manuel, Prince of Portugal.|
||19 October 1537 –
20 March 1538
|Died in infancy.|
||21 April 1539||Stillborn.|
Due to Philip II being a grandson of Manuel I of Portugal through his mother he was in the line of succession to the throne of Portugal, and claimed it after his uncle's death ( Henry, the Cardinal-King, in 1580), thus establishing the personal union between Spain and Portugal.
Charles also had four illegitimate children:
- Margaret of Austria (1522–1586), daughter of Johanna Maria van der Gheynst,  a servant of Charles I de Lalaing, Seigneur de Montigny, daughter of Gilles Johann van der Gheynst and wife Johanna van der Caye van Cocamby. Married firstly with Alessandro de' Medici, Duke of Florence, and secondly with Ottavio Farnese, Duke of Parma.
- Joanna of Austria (1522–1530), daughter of a noble lady from Nassau.
- Tadea of Austria (1523? – ca. 1562), daughter of Orsolina della Penna. Married with Sinibaldo di Copeschi.
- John of Austria (1547–1578), son of Barbara Blomberg, victor of the Battle of Lepanto
Charles V styled himself as Holy Roman Emperor since his election, according to a Papal dispensation conferred to the Habsburg family by Pope Julius II in 1508 and confirmed in 1519 to the prince-electors by the legates of Pope Leo X. Although Papal coronation was not necessary to confirm the Imperial title, Charles V was crowned in the city of Bologna by Pope Clement VII in the medieval fashion.
Charles V accumulated a large number of titles due to his vast inheritance of Burgundian, Spanish, and Austrian realms. Following the pacts of Worms (21 April 1521) and Brussels (7 February 1522), he secretly gave the Austrian lands to his younger brother Ferdinand and elevated him to the status of Archduke. Nevertheless, according to the agreements, Charles continued to style himself as Archduke of Austria and maintained that Ferdinand acted as his vassal and vicar.   Furthermore, the pacts of 1521–1522 imposed restrictions on the governorship and regency of Ferdinand. For example, all of Ferdinand's letters to Charles V were signed "your obedient brother and servant".  Nonetheless, the same agreements promised Ferdinand the designation as future emperor and the transfer of hereditary rights over Austria at the imperial succession.
Following the death of Louis II, King of Hungary and Bohemia, at the Battle of Mohacs in 1526, Charles V favored the election of Ferdinand as king of Hungary (and Croatia and Dalmatia) and Bohemia. Despite this, Charles also styled himself as king of Hungary and Bohemia and retained this titular use in official acts (such as his testament) as in the case of the Austrian lands. As a consequence, cartographers and historians have described those kingdoms both as realms of Charles V and as possessions of Ferdinand, not without confusion. Others, such as the Venetian envoys, reported that the states of Ferdinand were "all held in common with the Emperor". 
Therefore, although he had agreed on the future division of the dynasty between Ferdinand and Philip II of Spain, during his own reign Charles V conceived the existence of a single "House of Austria" of which he was the sole head.  In the abdications of 1554–1556, Charles left his personal possessions to Philip II and the Imperial title to Ferdinand. The titles of King of Hungary, of Dalmatia, Croatia, etc., were also nominally left to the Spanish line (in particular to Don Carlos, Prince of Asturias and son of Philip II). However, Charles's Imperial abdication marked the beginning of Ferdinand's suo jure rule in Austria and his other lands: despite the claims of Philip and his descendants, Hungary and Bohemia were left under the nominal and substantial rule of Ferdinand and his successors. Formal disputes between the two lines over Hungary and Bohemia will be solved with the Onate treaty of 1617.
Charles's full titulature went as follows:
Charles, by the grace of God, Emperor of the Romans, forever August, King of Germany, King of Italy, King of all Spains, of Castile, Aragon, León, of Hungary, of Dalmatia, of Croatia, Navarra, Grenada, Toledo, Valencia, Galicia, Majorca, Sevilla, Cordova, Murcia, Jaén, Algarves, Algeciras, Gibraltar, the Canary Islands, King of Two Sicilies, of Sardinia, Corsica, King of Jerusalem, King of the Indies, of the Islands and Mainland of the Ocean Sea, Archduke of Austria, Duke of Burgundy, Brabant, Lorraine, Styria, Carinthia, Carniola, Limburg, Luxembourg, Gelderland, Neopatria, Württemberg, Landgrave of Alsace, Prince of Swabia, Asturia and Catalonia, Count of Flanders, Habsburg, Tyrol, Gorizia, Barcelona, Artois, Burgundy Palatine, Hainaut, Holland, Seeland, Ferrette, Kyburg, Namur, Roussillon, Cerdagne, Drenthe, Zutphen, Margrave of the Holy Roman Empire, Burgau, Oristano and Gociano, Lord of Frisia, the Wendish March, Pordenone, Biscay, Molin[ disambiguation needed], Salins[ disambiguation needed], Tripoli and Mechelen.[ citation needed]
|Titular Duke of Burgundy||25 September 1506||16 January 1556||Charles II|
|Duke of Brabant||25 September 1506||25 October 1555||Charles II|
|Duke of Limburg||25 September 1506||25 October 1555||Charles II|
|Duke of Lothier||25 September 1506||25 October 1555||Charles II|
|Duke of Luxemburg||25 September 1506||25 October 1555||Charles III|
|Margrave of Namur||25 September 1506||25 October 1555||Charles II|
|Count Palatine of Burgundy||25 September 1506||5 February 1556||Charles II|
|Count of Artois||25 September 1506||25 October 1555||Charles II|
|Count of Charolais||25 September 1506||21 September 1558||Charles II|
|Count of Flanders||25 September 1506||25 October 1555||Charles III|
|Count of Hainault||25 September 1506||25 October 1555||Charles II|
|Count of Holland||25 September 1506||25 October 1555||Charles II|
|Count of Zeeland||25 September 1506||25 October 1555||Charles II|
|Duke of Guelders||12 September 1543||25 October 1555||Charles III|
|Count of Zutphen||12 September 1543||25 October 1555||Charles II|
|King of Castile and León||14 March 1516||16 January 1556||Charles I|
|King of Aragon and Sicily||14 March 1516||16 January 1556||Charles I|
|Count of Barcelona||14 March 1516||16 January 1556||Charles I|
|King of Naples||14 March 1516||25 July 1554||Charles IV|
|King of the Romans||26 October 1520||24 February 1530||Charles V|
|Holy Roman Emperor||28 June 1519||27 August 1556||Charles V|
|Archduke of Austria||12 January 1519||12 January 1521||Charles I|
Coat of arms of Charles I of Spain and V of the Holy Roman Empire according to the description: Arms of Charles I added to those of Castile, Leon, Aragon, Two Sicilies and Granada present in the previous coat, those of Austria, ancient Burgundy, modern Burgundy, Brabant, Flanders and Tyrol. Charles I also incorporates the pillars of Hercules with the inscription " Plus Ultra", representing the overseas empire and surrounding coat with the collar of the Golden Fleece, as sovereign of the Order ringing the shield with the imperial crown and Acola double-headed eagle of the Holy Roman Empire and behind it the Spanish Cross of Burgundy. From 1520 added to the corresponding quarter to Aragon and Sicily, one in which the arms of Jerusalem, Naples and Navarre are incorporated.
Variant of the Royal Bend of Castile used by Charles V, Holy Roman Emperor.
References to Charles V include a large number of legends and folk tales; literary renderings of historical events connected to Charles's life and romantic adventures, his relationship to Flanders, and his abdication; and products marketed in his name. 
Unusually among major European monarchs, Charles V discouraged monumental depictions of himself during his lifetime.
- The Charles V Monument in Palermo was erected in 1631 and depicts him triumphant following the Conquest of Tunis.
- Among other posthumous depictions, there are statues of Charles on the facade of the City Hall in Ghent and the Royal Palace of Caserta.
- A statue of Charles, donated by the city of Toledo, was erected in 1966 in the Prinsenhof in Ghent where he was born. 
- An imperial resolution of Franz Joseph I of Austria, dated February 28, 1863, included Charles V in the list of the "most famous Austrian rulers and generals worthy of everlasting emulation" and honored him with a life-size statue, made by the Bohemian sculptor Emanuel Max Ritter von Wachstein, located at the Museum of Military History, Vienna. 
- In De heerelycke ende vrolycke daeden van Keyser Carel den V, published by Joan de Grieck in 1674, the short stories, anecdotes, citations attributed to the emperor, and legends about his encounters with famous and ordinary people, depict a noble Christian monarch with a perfect cosmopolitan personality and a strong sense of humour. Conversely, in Charles De Coster's masterpiece Thyl Ulenspiegel (1867), after his death Charles V is consigned to Hell as punishment for the acts of the Inquisition under his rule, his punishment being that he would feel the pain of anyone tortured by the Inquisition. De Coster's book also mentions the story on the spectacles in the coat of arms of Oudenaarde, the one about a paysant of Berchem in Het geuzenboek (1979) by Louis Paul Boon, while Abraham Hans (1882–1939) included both tales in De liefdesavonturen van keizer Karel in Vlaanderen.
- Lord Byron's Ode to Napoleon Buonaparte refers to Charles as "The Spaniard".
- Charles V is a notable character in Simone de Beauvoir's All Men Are Mortal.
- In The Maltese Falcon, the title object is said to have been an intended gift to Charles V.
- Charles V appears as a character in the play Doctor Faustus by the Elizabethan playwright Christopher Marlowe. In Act 4 Scene 1 of the A Text, Faustus attends Court by the Emperor's request and with the assistance of Mephistopheles conjures up spirits representing Alexander the Great and his paramour as a demonstration of his magical powers.
- Ernst Krenek's opera Karl V (opus 73, 1930) examines the title character's career via flashbacks.
- In the third act of Giuseppe Verdi's opera Ernani, the election of Charles as Holy Roman Emperor is presented. Charles (Don Carlo in the opera) prays before the tomb of Charlemagne. With the announcement that he is elected as Carlo Quinto he declares an amnesty including the eponymous bandit Ernani who had followed him there to murder him as a rival for the love of Elvira. The opera, based on the Victor Hugo play Hernani, portrays Charles as a callous and cynical adventurer whose character is transformed by the election into a responsible and clement ruler.
- In another Verdi opera, Don Carlo, the final scene implies that it is Charles V, now living the last years of his life as a hermit, who rescues his grandson, Don Carlo, from his father Philip II and the Inquisition, by taking Carlo with him to his hermitage at the monastery in Yuste.
- A Flemish legend about Charles being served a beer at the village of Olen, as well as the emperor's lifelong preference of beer above wine, led to the naming of several beer varieties in his honor. The Haacht Brewery of Boortmeerbeek produces Charles Quint, while Het Anker Brewery in Mechelen produces Gouden Carolus, including a Grand Cru of the Emperor, brewed once a year on Charles V's birthday.     Grupo Cruzcampo brews Legado De Yuste in honor of Charles and attributes the inspiration to his Flemish origin and his last days at the monastery of Yuste.[ citation needed]
- Carlos V is the name of a popular chocolate bar in Mexico. Its tagline is "El Rey de los Chocolates" or "The King of Chocolates" and "Carlos V, El Emperador del Chocolate" or "Charles V, the Emperor of Chocolates."
- Charles V is portrayed by Hans Lefebre and is figured prominently in the 1953 film Martin Luther, covering Luther's years from 1505 to 1530.
- Charles V is portrayed by Torben Liebrecht and is figured prominently in the 2003 film Luther covering the life of Martin Luther up until the Diet of Augsburg.
- Charles V is portrayed in one episode of the Showtime series The Tudors by Sebastian Armesto.
- Charles V is the main subject of the TVE series Carlos, Rey Emperador and is portrayed by Álvaro Cervantes.
- Chesney, Elizabeth A.; Zegura, Elizabeth Chesney (2004). The Rabelais Encyclopedia. Greenwood Publishing Group. ISBN 9780313310348.; H. Micheal Tarver, ed. (2016). The Spanish Empire: A Historical Encyclopedia. 2. ABC-CLIO. p. 161. ISBN 978-1-61069-421-6.; Plain Truth. Ambassador College. 1984.; Ferer, Mary Tiffany (2012). Music and Ceremony at the Court of Charles V: The Capilla Flamenca and the Art of Political Promotion. Boydell Press. ISBN 9781843836995.
- Charles Quint, prince des Pays-Bas (in French). La Renaissance du Livre. 1943.
- MacCulloch, D. (2 September 2004). Reformation: Europe's House Divided 1490–1700. p. 216. ISBN 978-0-14-192660-5.
- Leitch, S. (27 September 2010). Mapping Ethnography in Early Modern Germany: New Worlds in Print Culture. Springer. ISBN 9780230112988 – via Google Books.
- Armitage, D. (2000). The Ideological Origins of the British Empire. Cambridge University Press. p. 32. ISBN 978-0-521-78978-3.
- Ferer, Mary Tiffany (2012). Music and Ceremony at the Court of Charles V: The Capilla Flamenca and the Art of Political Promotion. Boydell Press. ISBN 9781843836995.
- Smedley, Edward (1845). Encyclopædia metropolitana; Volume 17. London.
- Kanski, Jack J. (2019). History of the German speaking nations. ISBN 9781789017182.
- Pavlac, Brian A.; Lott, Elizabeth S. (30 June 2019). The Holy Roman Empire: A Historical Encyclopedia [2 volumes]. ABC-CLIO. ISBN 9781440848568 – via Google Books.
- Wilson, Peter H. (2010). The Thirty Years War, a sourcebook. ISBN 9781137069771.
- The Education of a christian prince, Erasmus of Rotterdam
- Emperor Charles V: The Growth and Destiny of a Man and of a World-empire, Karl Brandi
- Emperor, a new life of Charles V, Geoffrey Parker
- The Habsburgs: The Rise and Fall of a World Power, Martyn Rady
- Emperor, a new life of Charles V, Geoffrey Parker
- Charles V and the end of the Respublica Christiana, José Hernando Sanchez
- Charles was made honorific Archduke by Maximilian in 1508, and was recognized Prince of Asturias by the Spanish cortes in 1504 and 1510. "Cortes de los antiguos reinos de León y de Castilla; Manuel Colmeiro (1883)". Archived from the original on 10 June 2008. Retrieved 2012-08-23., "XXIII". Archived from the original on 10 June 2008. Retrieved 2012-08-23.
- Heath, Richard (2018). Charles V: Duty and Dynasty – The Emperor and his Changing World 1500–1558. p. 23. ISBN 978-1-725-85278-5.
- History of Spain, Joseph Perez
- Charles V, Pierre Chaunu
- Germany in the Holy Roman Empire, Whaley
- Madariaga Orbea, Juan (2014). Sociedad y lengua vasca en los siglos XVII y XVIII. Euskaltzaindia. p. 712.
- Charles V, Pierre Chaunu and Michèle Escamilla
- Cornelius August Wilkens (1897). "VIII. Juan de Valdés". Spanish Protestants in the Sixteenth Century. William Heinemann. p. 66. Retrieved 24 July 2015.
- Burke, "Languages and communities in early modern Europe" p. 28; Holzberger, "The letters of George Santayana" p. 299
- Emperor, a new life of Charles V, by Geoffrey Parker, pp. 8–9.
- Rady, Martyn (30 July 2014). The Emperor Charles V. Routledge. ISBN 9781317880820 – via Google Books.
- Emperor, a new life of Charles V, by Geoffrey Parker, p. 8.
- Jr, Everett Jenkins (7 May 2015). The Muslim Diaspora (Volume 2, 1500–1799): A Comprehensive Chronology of the Spread of Islam in Asia, Africa, Europe and the Americas. McFarland. ISBN 9781476608891 – via Google Books.
- Papadopoulos, Alex G. (15 November 1996).
Urban Regimes and Strategies: Building Europe's Central Executive District in Brussels. University of Chicago Press. p.
72 – via Internet Archive.
bruxelles imperial capital of charles v.
- Maitland, Robert; Ritchie, Brent W. (10 June 2019). City Tourism: National Capital Perspectives. CABI. ISBN 9781845935467 – via Google Books.
- Kamen, Henry (2005). Spain, 1469–1714: a society of conflict (3rd ed.). Harlow, United Kingdom: Pearson Education. ISBN 0-582-78464-6.
- "Gentenaars Stropdragers". Archived from the original on 4 January 2014. Retrieved 7 November 2015.
- "GILDE van de STROPPENDRAGERS". Retrieved 7 November 2015.
- Martínez Gil, Fernando (2007). "Corte renacentista". La invención de Toledo. Imágenes históricas de una identidad urbana. Almud, ediciones de Castilla-La Mancha. pp. 113–121. ISBN 978-84-934140-7-8.
- Martínez Gil, Fernando (1999). "Toledo es Corte (1480-1561)". Historia de Toledo. Azacanes. pp. 259–308. ISBN 84-88480-19-9.
- "Cortes de los antiguos reinos de León y de Castilla; Manuel Colmeiro (1883)". Archived from the original on 10 June 2008. Retrieved 23 August 2012., "XXIII". Archived from the original on 10 June 2008. Retrieved 23 August 2012.
- Estudio documental de la moneda castellana de Carlos I fabricada en los Países Bajos (1517); José María de Francisco Olmos Archived 5 February 2012 at the Wayback Machine, Revista General de Información y Documentación 2003, vol 13, núm.2 (Universidad complutense de Madrid), page 137
- Estudio documental de la moneda castellana de Juana la Loca fabricada en los Países Bajos (1505–1506); José María de Francisco Olmos Archived 14 January 2012 at the Wayback Machine, Revista General de Información y Documentación 2002, vol 12, núm.2 (Universidad complutense de Madrid), page 299
- Estudio documental de la moneda castellana de Carlos I fabricada en los Países Bajos (1517); José María de Francisco Olmos, page 138 Archived 5 February 2012 at the Wayback Machine
- Estudio documental de la moneda castellana de Carlos I fabricada en los Países Bajos (1517); José María de Francisco Olmos, pp. 139–140 Archived 5 February 2012 at the Wayback Machine
- Encyclopædia Britannica, 1911 edition.
- "Cortes de los antiguos reinos de León y de Castilla". Archived from the original on 24 February 2013. Retrieved 1 June 2016.; Manuel Colmeiro (1883), chapter XXIV
- Historia general de España; Modesto Lafuente (1861), pp. 51–52.
- Fueros, observancias y actos de corte del Reino de Aragón; Santiago Penén y Debesa, Pascual Savall y Dronda, Miguel Clemente (1866) Archived 10 June 2008 at the Wayback Machine, page 64 Archived 10 June 2008 at the Wayback Machine
- Monreal, Gregorio; Jimeno, Roldan (2012). Conquista e Incorporación de Navarra a Castilla. Pamplona-Iruña: Pamiela. pp. 37–43. ISBN 978-84-7681-736-0.
- The Albany Law Journal: A Monthly Record of the Law and the Lawyers. Weed, Parsons. 1899.
- Aurelio Espinosa, "The grand strategy of Charles V (1500-1558): Castile, war, and dynastic priority in the Mediterranean." Journal of Early Modern History 9.3 (2005): 239-283. Online
- Elliot, J.H. Imperial Spain 1469–1716. Penguin Books (New York: 2002), pg. 208.
- Litta, Count Pompeo. Famous Italian Families, Stampa di Milano.
- Prescott, William Hickling (1873). History of the Conquest of Mexico, with a Preliminary View of Ancient Mexican Civilization, and the Life of the Conqueror, Hernando Cortes (3rd ed.). Electronic Text Center, University of Virginia Library. ISBN 1-152-29570-5.
- Josefina Cintrón Tiryakian et al. "The Indian Labor Policy of Charles V" El Trabajo y Los Trabajadores en la Historia de México (1979), pp 9-41.
- Keys, David (17 August 2018). "Details of horrific first voyages in transatlantic slave trade revealed". The Independent. Retrieved 21 August 2018.
- Heath, Richard (2018). Charles V: Duty and Dynasty – The Emperor and his Changing World 1500–1558. pp. 269–272. ISBN 978-1-725-85278-5.
- Haskin, Frederic (1913). The Panama Canal. Doubleday, Page & Company.
- William Maltby, The Reign of Charles V (St. Martin's Press, 2002)
- Claims that he gained the imperial crown through bribery have been questioned. H.J. Cohn, "Did Bribes Induce the German Electors to Choose Charles V as Emperor in 1519?" German History (2001) 19#1 pp 1–27
- "Royal Collection – The Knights of the Garter under Henry VIII". royalcollection.org.uk. Archived from the original on 6 December 2011. Retrieved 16 December 2015.
- Angus Konstam, Pavia 1525: the climax of the Italian Wars (Osprey, 1996).
- Holmes (1993), p. 192
- Froude (1891), p. 35, pp. 90–91, pp. 96–97 Note: the link goes to page 480, then click the View All option
- Quoted from: Bryan W. Ball. A Great Expectation. Brill Publishers, 1975. ISBN 90-04-04315-2. Page 142.
- Sandra Arlinghaus. "Life Span of Suleiman The Magnificent, 1494–1566". Personal.umich.edu. Retrieved 8 June 2012.
- Bruce Ware Allen, "Emperor vs. Pirate Tunis, 1535." MHQ: Quarterly Journal of Military History (Winter 2014) 26#2 pp 58-63.
- In particular, in this Truce of Adrianople (1547) Charles was only referred to as "King of Spain" instead of by his extensive titulature. (see Crowley, p. 89)
- Stanley Sandler, ed. (2002). Ground Warfare: An International Encyclopedia, Volume 1. ISBN 1-57607-733-0.
- "A Habsburg-Persian alliance against the Ottomans finally brought a respite from the Turkish threat in the 1540s. This entanglement kept Suleiman tied down on his eastern border, relieving the pressure on Carlos V" in The Indian Ocean in world history? Milo Kearney – 2004 – p.112
- "Théâtre de tous les peuples et nations de la terre avec leurs habits et ornemens divers, tant anciens que modernes, diligemment depeints au naturel par Luc Dheere peintre et sculpteur Gantois[manuscript]". lib.ugent.be. Retrieved 25 August 2020.
- Gottfried G. Krodel, "Law, Order, and the Almighty Taler: The Empire in Action at the 1530 Diet of Augsburg." Sixteenth Century Journal (1982): 75-106 online.
- Christopher W. Close, "Estate Solidarity and Empire: Charles V's Failed Attempt to Revive the Swabian League." Archiv für Reformationsgeschichte (2013_ 104#1 pp 134-157, in English.
- Paula Sutter Fichtner, "When Brothers Agree: Bohemia, The Habsburgs, and the Schmalkaldic Wars, 1546-1547." Austrian History Yearbook (1975), Vol. 11, pp 67-78.
- Tracy, 2002, pp 229-248.
- "Henry VIII: June 1518, 1–15 Pages 1302–1311 Letters and Papers, Foreign and Domestic, Henry VIII, Volume 2, 1515–1518. Originally published by Her Majesty's Stationery Office, London, 1864". British History Online.
- Palace of Charles V Archived 24 September 2016 at the Wayback Machine, Alhambra.org
- Kamen, H. (29 May 1997). Philip of Spain. Yale University Press. p. 2. ISBN 978-0-300-07081-1.
- Kamen 1997, pp. 6–7.
- "The Glory – The Collection". Museo Nacional del Prado.
- "Empress Isabella of Portugal – The Collection". Museo Nacional del Prado.
- "Thomas Crecquillon: Missa 'Mort m'a privé', motets and chansons". The Brabant Ensemble.
- Francisco C. Ceballos, and G. Álvarez, "Royal dynasties as human inbreeding laboratories: the Habsburgs." Heredity 111.2 (2013): 114-121 online.
- H. Schneble. "German Epilepsy Museum Kork". Epilepsiemuseum.de. Retrieved 8 June 2012.
- "Tests confirm old emperor's gout diagnosis." His The Record. 4 August 2006, Nation.
- Dr. Martyn Rady, University of London, lecture 2000.[ citation needed]
- Fernand Braudel (1995). The Mediterranean and the Mediterranean World in the Age of Philip II. University of California Press. pp. 935–936. ISBN 978-0-520-20330-3. Retrieved 23 February 2016.
- Gerhard Geißler: European documents from five centuries. Esche, Leipzig 1939. p. 85.
- Setton, K. (1984). The Papacy and the Levant (1204–1571), Volume IV: The Sixteenth Century from Julius III to Pius V. Memoirs. 162. Philadelphia: American Philosophical Society. p. 716. ISBN 978-0-87169-162-0. ISSN 0065-9738.
- Robinson, H., ed. (1846). Zurich Letters. Cambridge University Press. p. 182.
- Joachim Whaley (2012). Germany and the Holy Roman Empire: Volume I: Maximilian I to the Peace of Westphalia, 1493–1648. OUP Oxford. p. 343. ISBN 978-0-19-873101-6. Retrieved 23 February 2016.
- Alonso, Jordi; J. de Zulueta; et al. (August 2006). "The severe gout of Holy Roman Emperor Charles V". N. Engl. J. Med. 355 (5): 516–20. doi: 10.1056/NEJMon060780. PMID 16885558.
- William Robertson (1828). History of Charles V. Paris : Baudry, at the foreign library. p. 580. Retrieved 16 December 2017.
- de Zulueta, J. (June 2007). "The cause of death of Emperor Charles V". Parassitologia. 49 (1–2): 107–109. PMID 18412053.
- Kamen 1997, p. 65.
- "El Escorial History – El Escorial". el-escorial.com. Retrieved 19 July 2017.
- "A-Panteo.Pdf" (PDF). Retrieved 10 June 2019.
- Fletcher 2016, p. 50.
- Thomas A Brady JR (13 July 2009). German Histories in the Age of Reformations, 1400–1650. ISBN 9781139481151.
- Foulke, Roland Roberts (1920). "A Treatise on International Law: With an Introductory Essay on the Definition and Nature of the Laws of Human Conduct".
- Vehse, Carl Eduard (1856). "Memoirs of the Court, Aristocracy, and Diplomacy of Austria".
- Relazione di Germania 1526 in Relazioni degli ambasciatori Veneti al Senato: Germania
- Rady, Martyn (30 July 2014). The Emperor Charles V. ISBN 9781317880820.
- Wurzbach, Constantin, von, ed. (1861). . Biographisches Lexikon des Kaiserthums Oesterreich [Biographical Encyclopedia of the Austrian Empire] (in German). 7. p. 112 – via Wikisource.
- Chisholm, Hugh, ed. (1911). Encyclopædia Britannica. 15 (11th ed.). Cambridge University Press. .
- Holland, Arthur William (1911). Encyclopædia Britannica. 17 (11th ed.). Cambridge University Press. . In Chisholm, Hugh (ed.).
- Poupardin, René (1911). . In Chisholm, Hugh (ed.). Encyclopædia Britannica. 5 (11th ed.). Cambridge University Press.
- Chisholm, Hugh, ed. (1911). Encyclopædia Britannica. 10 (11th ed.). Cambridge University Press. .
- Chisholm, Hugh, ed. (1911). Encyclopædia Britannica. 14 (11th ed.). Cambridge University Press. .
- Chisholm, Hugh, ed. (1911). Encyclopædia Britannica. 11 (11th ed.). Cambridge University Press. .
- Urban, William (2003). Tannenberg and After. Chicago: Lithuanian Research and Studies Center. p. 191. ISBN 0-929700-25-2.
- Stephens, Henry Morse (1903). The story of Portugal. G.P. Putnam's Sons. p. 139. Retrieved 11 July 2018.
- Kiening, Christian (1994). "Rhétorique de la perte. L'exemple de la mort d'Isabelle de Bourbon (1465)". Médiévales (in French). 13 (27): 15–24. doi: 10.3406/medi.1994.1307.
- Chisholm, Hugh, ed. (1911). Encyclopædia Britannica. 15 (11th ed.). Cambridge University Press. .
- Ortega Gato, Esteban (1999). "Los Enríquez, Almirantes de Castilla" (PDF). Publicaciones de la Institución "Tello Téllez de Meneses" (in Spanish). 70: 42. ISSN 0210-7317.
- Chisholm, Hugh, ed. (1911). Encyclopædia Britannica. 15 (11th ed.). Cambridge University Press. .
- Downey, Kirstin (November 2015). Isabella: The Warrior Queen. Knopf Doubleday Publishing Group. p. 28. ISBN 9780307742162. Retrieved 17 July 2018.
- Jones 1997, p. 122. sfn error: no target: CITEREFJones1997 ( help)
- Earenfight 2015, p. 142. sfn error: no target: CITEREFEarenfight2015 ( help)
- Heymans, Frans (4 June 2007). "Keizer Karel in de literatuur". Overzichten (in Dutch). Literair Gent, an initiative by the Municipal Public Library of Ghent and 'Gent Cultuurstad'. Archived from the original on 27 September 2007. Retrieved 20 July 2007.
- "Prinsenhof: Medieval gem in the city centre". VisitGent.
- Johann Christoph Allmayer-Beck : The Museum of Military History in Vienna. The museum and its representative rooms . Kiesel Verlag, Salzburg 1981, ISBN 3-7023-0113-5 , p. 30.
- "Charles V". Global Beer Network, Santa Barbara, California, U.S.A. Archived from the original on 27 September 2007. Retrieved 18 July 2007.
- "Charles Quint Golden Blond". Haacht Brewery. Retrieved 19 July 2012.
- "Charles Quint Ruby Red". Haacht Brewery. Retrieved 19 July 2012.
- "Beers by Het Anker". Brewery Het Anker. Archived from the original on 2 July 2007. Retrieved 18 July 2007.
- Atkins, Sinclair. "Charles V and the Turks", History Today (Dec 1980) 30#12 pp 13–18
- Blockmans, W. P., and Nicolette Mout. The World of Emperor Charles V (2005)
- Brandi, Karl. The emperor Charles V: The growth and destiny of a man and of a world-empire (1939) online
- Espinosa, Aurelio. "The Grand Strategy of Charles V (1500–1558): Castile, War, and Dynastic Priority in the Mediterranean", Journal of Early Modern History (2005) 9#3 pp 239–283. online.
- Espinosa, Aurelio. "The Spanish Reformation: Institutional Reform, Taxation, and the Secularization of Ecclesiastical Properties under Charles V", Sixteenth Century Journal (2006) 37#1 pp 3–24. JSTOR 20477694.
- Espinosa, Aurelio. The Empire of the Cities: Emperor Charles V, the Comunero Revolt, and the Transformation of the Spanish System (2008)
- Ferer, Mary Tiffany. Music and Ceremony at the Court of Charles V: The Capilla Flamenca and the Art of Political Promotion (Boydell & Brewer, 2012). ISBN 9781843836995
- Fletcher, Catherine (2016). The Black Prince of Florence: The Spectacular Life and Treacherous World of Alessandro de' Medici. Oxford University Press.
- Froude, James Anthony (1891). The Divorce of Catherine of Aragon. Kessinger, reprint 2005. ISBN 1417971096.
- Headley, John M. Emperor & His Chancellor: A Study of the Imperial Chancellery under Gattinara (1983) covers 1518 to 1530.
- Heath, Richard. Charles V: Duty and Dynasty. The Emperor and his Changing World 1500-1558. (2018) ISBN 9781725852785
- Holmes, David L. (1993). A Brief History of the Episcopal Church. Continuum International Publishing Group. ISBN 1563380609. Retrieved 23 February 2016.
- Kleinschmidt, Harald. Charles V: The World Emperor ISBN 9780750924047
- Merriman, Roger Bigelow. The rise of the Spanish empire in the Old world and the New: Volume 3 The Emperor (1925) online
- Norwich, John Julius. Four Princes: Henry VIII, Francis I, Charles V, Suleiman the Magnificent and the Obsessions that Forged Modern Europe (2017), popular history; excerpt
- Parker, Geoffrey. Emperor: A New Life of Charles V (2019) excerpt
- Reston Jr, James. Defenders of the Faith: Charles V, Suleyman the Magnificent, and the Battle for Europe, 1520-1536 (2009), popular history.
- Richardson, Glenn. Renaissance Monarchy: The Reigns of Henry VIII, Francis I & Charles V (2002) 246pp. covers 1497 to 1558.
- Rodriguez-Salgado, Mia. Changing Face of Empire: Charles V, Philip II & Habsburg Authority, 1551-1559 (1988), 375pp.
- Rosenthal, Earl E. Palace of Charles V in Granada (1986) 383pp.
- Saint-Saëns, Alain, ed. Young Charles V. (New Orleans: University Press of the South, 2000).
- Tracy, James D. Emperor Charles V, impresario of war: campaign strategy, international finance, and domestic politics (Cambridge UP, 2002). excerpt
- Salvatore Agati (2009). Carlo V e la Sicilia. Tra guerre, rivolte, fede e ragion di Stato, Giuseppe Maimone Editore, Catania 2009, ISBN 978-88-7751-287-1 (in Italian)
- D'Amico, Juan Carlos. Charles Quint, Maître du Monde: Entre Mythe et Realite 2004, 290p. (in French)
- Norbert Conrads: Die Abdankung Kaiser Karls V. Abschiedsvorlesung, Universität Stuttgart, 2003 ( text Archived 17 July 2011 at the Wayback Machine) (in German)
- Stephan Diller, Joachim Andraschke, Martin Brecht: Kaiser Karl V. und seine Zeit. Ausstellungskatalog. Universitäts-Verlag, Bamberg 2000, ISBN 3-933463-06-8 (in German)
- Alfred Kohler: Karl V. 1500–1558. Eine Biographie. C. H. Beck, München 2001, ISBN 3-406-45359-7 (in German)
- Alfred Kohler: Quellen zur Geschichte Karls V. Wissenschaftliche Buchgesellschaft, Darmstadt 1990, ISBN 3-534-04820-2 (in German)
- Alfred Kohler, Barbara Haider. Christine Ortner (Hrsg): Karl V. 1500–1558. Neue Perspektiven seiner Herrschaft in Europa und Übersee. Verlag der Österreichischen Akademie der Wissenschaften, Wien 2002, ISBN 3-7001-3054-6 (in German)
- Ernst Schulin: Kaiser Karl V. Geschichte eines übergroßen Wirkungsbereichs. Kohlhammer Verlag, Stuttgart 1999, ISBN 3-17-015695-0 (in German)
- Ferdinant Seibt: Karl V. Goldmann, München 1999, ISBN 3-442-75511-5 (in German)
- Manuel Fernández Álvarez: Imperator mundi: Karl V. – Kaiser des Heiligen Römischen Reiches Deutscher Nation.. Stuttgart 1977, ISBN 3-7630-1178-1 (in German)
|Wikiquote has quotations related to: Charles V, Holy Roman Emperor|
|Wikimedia Commons has media related to Charles V, Holy Roman Emperor.|
- Armstrong, E. (1911). . In Hugh Chisholm (ed.). Encyclopædia Britannica 11th ed. 5. Cambridge University Press.
- Beach, Chandler B., ed. (1914). . . 1. Chicago: F. E. Compton and Co.
- Genealogy history of Charles V and his ancestors
- The Life and Times of Emperor Charles V 1500–1558
- The Library of Charles V preserved in the National Library of France
- Luminarium Encyclopedia biography of Charles V, Holy Roman Emperor
- New Advent biography of Charles V, Holy Roman Emperor
- (in Italian) Charles V and the Tiburtine Sibyl
- Charles V the Habsburg emperor, video
Charles V, Holy Roman EmperorBorn: 24 February 1500 Died: 21 September 1558
Philip the Handsome
Duke of Brabant,
Margrave of Namur;
Count of Artois, Flanders, Hainaut, Holland, and Zeeland;
Count Palatine of Burgundy
Philip the Prudent
Joanna the Mad
as sole ruler
King of Naples|
with Joanna III (1516–1554)
King of Castile,
Count of Barcelona, Roussillon and Cerdagne
with Joanna (1516–1555)
William the Rich
Duke of Guelders|
Count of Zutphen
Archduke of Austria
Duke of Styria, Carinthia and Carniola
Count of Tyrol
King of Germany|
Holy Roman Emperor|
King of Italy
Prince of Asturias
Title next held byPhilip (II)
Prince of Girona|