7-PET is an
opioidanalgesic drug that has 300 times the potency of
morphine by weight.[1] It was discovered by K.W. Bentley[2] and is related to the more well known
oripavine derivative
etorphine, which is used as a
veterinary painkiller and
anesthetic medication for the sedation of large animals such as elephants, giraffes, and rhinos. 7-PET itself has a 3-O-methyl ether which reduces potency, but the 3-OH derivative is around 2200 times more potent than morphine, almost the same potency as etorphine as a
μagonist,[3][4] and unexpectedly the 3-hydrogen compound is also around the same potency of 2000 times morphine.[5]
Unlike etorphine, 7-PET is not controlled under the UN drug conventions, but it might still be considered to be a
controlled substance analogue of etorphine on the grounds of its related chemical structure in some jurisdictions such as the United States, Canada, Australia, and New Zealand.
^Bentley KW, Hardy DG, Meek B (June 1967). "Novel analgesics and molecular rearrangements in the morphine-thebaine group. II. Alcohols derived from 6,14-endo-etheno- and 6,14-endo-ethanotetrahydrothebaine". Journal of the American Chemical Society. 89 (13): 3273–3280.
doi:
10.1021/ja00989a031.
PMID6042763.
^Bentley KW, Lewis JW (1973). Kosterlitz HW, Collier HO, Villarreal JE (eds.). Agonist and Antagonist Actions of Narcotic Analgesic Drugs. Baltimore: University Park Press. pp. 7–16.
ISBN978-0839107255.
LCCN72012612.
^Lewis JW, Readhead MJ (May 1970). "Novel analgetics and molecular rearrangements in the morphine-thebaine group. 18. 3-deoxy-6,14-endo-etheno-6,7,8,14-tetrahydrooripavines". Journal of Medicinal Chemistry. 13 (3): 525–527.
doi:
10.1021/jm00297a041.
PMID5441135.