The desmogleins are a family of desmosomal
cadherins consisting of proteins
DSG1,
DSG2,
DSG3, and
DSG4. They play a role in the formation of
desmosomes that join cells to one another.[1]
Desmoglein proteins are a type of cadherin, which is a
transmembrane protein that binds with other cadherins to form junctions known as desmosomes between cells. These desmoglein proteins thus hold cells together, but, when the body starts producing
antibodies against desmoglein, these junctions break down, and this results in subsequent
blister or
vesicle formation.[5][6]