Cadherin-16 is a protein that in humans is encoded by the CDH16 gene.[5][6][7]
This gene is a member of the
cadherin superfamily, genes encoding calcium-dependent, membrane-associated
glycoproteins. Mapped to a previously identified cluster of cadherin genes on
chromosome 16q22.1, the gene localizes with superfamily members
CDH1,
CDH3,
CDH5,
CDH8 and
CDH11. The protein consists of an
extracellular domain containing 6 cadherin domains, a
transmembrane region and a truncated
cytoplasmic domain but lacks the
prosequence and
tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in the kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the
morphogenic direction of tissue development.[7]
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