From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Paired amphipathic helix protein Sin3b is a
protein that in humans is encoded by the SIN3B
gene .
[5]
[6]
Interactions
SIN3B has been shown to
interact with
HDAC1 ,
[7]
[8]
Zinc finger and BTB domain-containing protein 16 ,
[9]
SUDS3
[10] and
IKZF1 .
[8]
[11]
See also
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000127511 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000031622 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1998).
"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro" . DNA Research . 5 (3): 169–76.
doi :
10.1093/dnares/5.3.169 .
PMID
9734811 .
^
"Entrez Gene: SIN3B SIN3 homolog B, transcription regulator (yeast)" .
^ Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (Aug 1999).
"Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation" . Genes & Development . 13 (15): 1924–35.
doi :
10.1101/gad.13.15.1924 .
PMC
316920 .
PMID
10444591 .
^
a
b Koipally J, Renold A, Kim J, Georgopoulos K (Jun 1999).
"Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes" . The EMBO Journal . 18 (11): 3090–100.
doi :
10.1093/emboj/18.11.3090 .
PMC
1171390 .
PMID
10357820 .
^ David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A (May 1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene . 16 (19): 2549–56.
doi :
10.1038/sj.onc.1202043 .
PMID
9627120 .
S2CID
655636 .
^ Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA (Apr 2002).
"Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex" . Molecular and Cellular Biology . 22 (8): 2743–50.
doi :
10.1128/MCB.22.8.2743-2750.2002 .
PMC
133736 .
PMID
11909966 .
^ Koipally J, Georgopoulos K (Aug 2002).
"A molecular dissection of the repression circuitry of Ikaros" . The Journal of Biological Chemistry . 277 (31): 27697–705.
doi :
10.1074/jbc.M201694200 .
PMID
12015313 .
Further reading
Ayer DE, Lawrence QA, Eisenman RN (Mar 1995).
"Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3" . Cell . 80 (5): 767–76.
doi :
10.1016/0092-8674(95)90355-0 .
PMID
7889570 .
S2CID
8749951 .
David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A (May 1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene . 16 (19): 2549–56.
doi :
10.1038/sj.onc.1202043 .
PMID
9627120 .
S2CID
655636 .
Koipally J, Renold A, Kim J, Georgopoulos K (Jun 1999).
"Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes" . The EMBO Journal . 18 (11): 3090–100.
doi :
10.1093/emboj/18.11.3090 .
PMC
1171390 .
PMID
10357820 .
Naruse Y, Aoki T, Kojima T, Mori N (Nov 1999).
"Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes" . Proceedings of the National Academy of Sciences of the United States of America . 96 (24): 13691–6.
Bibcode :
1999PNAS...9613691N .
doi :
10.1073/pnas.96.24.13691 .
PMC
24126 .
PMID
10570134 .
Spronk CA, Tessari M, Kaan AM, Jansen JF, Vermeulen M, Stunnenberg HG, Vuister GW (Dec 2000). "The Mad1-Sin3B interaction involves a novel helical fold". Nature Structural Biology . 7 (12): 1100–4.
doi :
10.1038/81944 .
PMID
11101889 .
S2CID
12451972 .
Spronk CA, Jansen JF, Tessari M, Kaan AM, Aelen J, Lasonder E, Stunnenberg HG, Vuister GW (Apr 2001). "Sequence-specific assignment of the PAH2 domain of Sin3B free and bound to Mad1". Journal of Biomolecular NMR . 19 (4): 377–8.
doi :
10.1023/A:1011262214741 .
hdl :
2066/79476 .
PMID
11370785 .
S2CID
31789681 .
Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA (Apr 2002).
"Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex" . Molecular and Cellular Biology . 22 (8): 2743–50.
doi :
10.1128/MCB.22.8.2743-2750.2002 .
PMC
133736 .
PMID
11909966 .
Rayman JB, Takahashi Y, Indjeian VB, Dannenberg JH, Catchpole S, Watson RJ, te Riele H, Dynlacht BD (Apr 2002).
"E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex" . Genes & Development . 16 (8): 933–47.
doi :
10.1101/gad.969202 .
PMC
152357 .
PMID
11959842 .
Koipally J, Georgopoulos K (Aug 2002).
"A molecular dissection of the repression circuitry of Ikaros" . The Journal of Biological Chemistry . 277 (31): 27697–705.
doi :
10.1074/jbc.M201694200 .
PMID
12015313 .
Yang L, Mei Q, Zielinska-Kwiatkowska A, Matsui Y, Blackburn ML, Benedetti D, Krumm AA, Taborsky GJ, Chansky HA (Feb 2003).
"An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B" . The Biochemical Journal . 369 (Pt 3): 651–7.
doi :
10.1042/BJ20020854 .
PMC
1223118 .
PMID
12398767 .
Petrie K, Guidez F, Howell L, Healy L, Waxman S, Greaves M, Zelent A (May 2003).
"The histone deacetylase 9 gene encodes multiple protein isoforms" . The Journal of Biological Chemistry . 278 (18): 16059–72.
doi :
10.1074/jbc.M212935200 .
PMID
12590135 .
Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W (Apr 2003).
"Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1" . Genes & Development . 17 (7): 896–911.
doi :
10.1101/gad.252103 .
PMC
196026 .
PMID
12670868 .
Dugast-Darzacq C, Pirity M, Blanck JK, Scherl A, Schreiber-Agus N (Nov 2004). "Mxi1-SRalpha: a novel Mxi1 isoform with enhanced transcriptional repression potential". Oncogene . 23 (55): 8887–99.
doi :
10.1038/sj.onc.1208107 .
PMID
15467743 .
S2CID
30045920 .
Rampalli S, Pavithra L, Bhatt A, Kundu TK, Chattopadhyay S (Oct 2005).
"Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex" . Molecular and Cellular Biology . 25 (19): 8415–29.
doi :
10.1128/MCB.25.19.8415-8429.2005 .
PMC
1265755 .
PMID
16166625 .
Xu Y, Sengupta PK, Seto E, Smith BD (Apr 2006).
"Regulatory factor for X-box family proteins differentially interact with histone deacetylases to repress collagen alpha2(I) gene (COL1A2) expression" . The Journal of Biological Chemistry . 281 (14): 9260–70.
doi :
10.1074/jbc.M511724200 .
PMC
1434794 .
PMID
16464847 .
PDB gallery
1e91 : STRUCTURE OF THE COMPLEX OF THE MAD1-SIN3B INTERACTION DOMAINS
1pd7 : Extended SID of Mad1 bound to the PAH2 domain of mSin3B
2cr7 : Solution structure of the first PAH domain of the mouse transcriptional repressor SIN3B
2czy : Solution structure of the NRSF/REST-mSin3B PAH1 complex
2f05 : Solution structure of free PAH2 domain of mSin3B
External links
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .