From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Ligand-dependent corepressor is a
protein that in humans is encoded by the LCOR
gene .
[3]
[4]
[5]
Function LCOR is a transcriptional
corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound
nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box.
[5]
References
^
a b c
GRCh38: Ensembl release 89: ENSG00000196233 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Fernandes I, Bastien Y, Wai T, Nygard K, Lin R, Cormier O, Lee HS, Eng F, Bertos NR, Pelletier N, Mader S, Han VK, Yang XJ, White JH (Jan 2003).
"Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms" . Mol Cell . 11 (1): 139–50.
doi :
10.1016/S1097-2765(03)00014-5 .
PMID
12535528 .
^ White JH, Fernandes I, Mader S, Yang XJ (Jun 2004). "Corepressor recruitment by agonist-bound nuclear receptors". Vitam Horm . Vitamins & Hormones. 68 : 123–43.
doi :
10.1016/S0083-6729(04)68004-6 .
ISBN
978-0-12-709868-5 PMID
15193453 . ^
a b
"Entrez Gene: LCOR ligand dependent nuclear receptor corepressor" .
Further reading
Nagase T, Nakayama M, Nakajima D, et al. (2001).
"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 8 (2): 85–95.
doi :
10.1093/dnares/8.2.85 .
PMID
11347906 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 . Kunieda T, Park JM, Takeuchi H, Kubo T (2003). "Identification and characterization of Mlr1,2: two mouse homologues of Mblk-1, a transcription factor from the honeybee brain(1)". FEBS Lett . 535 (1–3): 61–5.
doi :
10.1016/S0014-5793(02)03858-9 .
PMID
12560079 .
S2CID
83745027 . Shi Y, Sawada J, Sui G, et al. (2003). "Coordinated histone modifications mediated by a CtBP co-repressor complex". Nature . 422 (6933): 735–8.
Bibcode :
2003Natur.422..735S .
doi :
10.1038/nature01550 .
PMID
12700765 .
S2CID
2670859 . Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 . Deloukas P, Earthrowl ME, Grafham DV, et al. (2004).
"The DNA sequence and comparative analysis of human chromosome 10" . Nature . 429 (6990): 375–81.
Bibcode :
2004Natur.429..375D .
doi :
10.1038/nature02462 .
PMID
15164054 . Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
External links
PDBe-KB provides an overview of all the structure information available in the PDB for Human Ligand-dependent corepressor
