From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
The nuclear receptor co-repressor 1 also known as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 (TRAC-1 ) is a
protein that in humans is encoded by the NCOR1
gene .
[5]
[6]
NCOR1 is a transcriptional coregulatory protein which contains several
nuclear receptor interacting domains. In addition, NCOR1 appears to recruit
histone deacetylases to DNA promoter regions. Hence NCOR1 assists nuclear receptors in the down regulation of gene expression.
[5]
[7]
Loss of function of this protein significantly increases the strength and power of mouse muscles.
[8]
Family
It is a member of the family of nuclear receptor corepressors; the other human protein that is a member of that family is
Nuclear receptor co-repressor 2 .
[9]
Interactions
Nuclear receptor co-repressor 1 has been shown to
interact with:
Androgen receptor ,
[10]
[11]
[12]
[13]
CHD1 ,
[14]
Calcitriol receptor
[15]
[16]
GPS2 ,
[17]
[18]
[19]
Glucocorticoid receptor ,
[20]
[21]
HDAC3 ,
[17]
[18]
[19]
[22]
[23]
[24]
[25]
HDAC4 ,
[24]
[26]
HDAC7A ,
[22]
HDAC9 ,
[27]
HEY2 ,
[28]
Histone deacetylase 5 ,
[17]
[26]
MAP3K7IP2 ,
[29]
MECP2 ,
[30]
Peroxisome proliferator-activated receptor alpha ,
[31]
Peroxisome proliferator-activated receptor gamma
Promyelocytic leukemia protein ,
[32]
RUNX1T1 ,
[33]
[34]
Retinoic acid receptor alpha ,
[31]
[35]
Retinoic acid receptor gamma ,
[31]
SAP30 ,
[25]
[36]
TBL1XR1 ,
[17]
[18]
[19]
TBL1X ,
[17]
[19]
[23]
[37] and
ZBTB33 .
[18]
Further reading
Minucci S, Pelicci PG (1999). "Retinoid receptors in health and disease: co-regulators and the chromatin connection". Semin. Cell Dev. Biol . 10 (2): 215–25.
doi :
10.1006/scdb.1999.0303 .
PMID
10441075 .
Downes M, Burke LJ, Bailey PJ, Muscat GE (1997).
"Two receptor interaction domains in the corepressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbA alpha and RVR: physical association is dependent on the E region of the orphan receptors" . Nucleic Acids Res . 24 (22): 4379–86.
doi :
10.1093/nar/24.22.4379 .
PMC
146280 .
PMID
8948627 .
Tagami T, Madison LD, Nagaya T, Jameson JL (1997).
"Nuclear receptor corepressors activate rather than suppress basal transcription of genes that are negatively regulated by thyroid hormone" . Mol. Cell. Biol . 17 (5): 2642–8.
doi :
10.1128/mcb.17.5.2642 .
PMC
232114 .
PMID
9111334 .
Zamir I, Dawson J, Lavinsky RM, Glass CK, Rosenfeld MG, Lazar MA (1998).
"Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex" . Proc. Natl. Acad. Sci. U.S.A . 94 (26): 14400–5.
doi :
10.1073/pnas.94.26.14400 .
PMC
24996 .
PMID
9405624 .
Burke LJ, Downes M, Laudet V, Muscat GE (1998).
"Identification and characterization of a novel corepressor interaction region in RVR and Rev-erbA alpha" . Mol. Endocrinol . 12 (2): 248–62.
doi :
10.1210/mend.12.2.0061 .
PMID
9482666 .
Guidez F, Ivins S, Zhu J, Söderström M, Waxman S, Zelent A (1998).
"Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia" . Blood . 91 (8): 2634–42.
doi :
10.1182/blood.V91.8.2634.2634_2634_2642 .
PMID
9531570 .
Kao HY, Ordentlich P, Koyano-Nakagawa N, Tang Z, Downes M, Kintner CR, Evans RM, Kadesch T (1998).
"A histone deacetylase corepressor complex regulates the Notch signal transduction pathway" . Genes Dev . 12 (15): 2269–77.
doi :
10.1101/gad.12.15.2269 .
PMC
317043 .
PMID
9694793 .
Laherty CD, Billin AN, Lavinsky RM, Yochum GS, Bush AC, Sun JM, Mullen TM, Davie JR, Rose DW, Glass CK, Rosenfeld MG, Ayer DE, Eisenman RN (1998).
"SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors" . Mol. Cell . 2 (1): 33–42.
doi :
10.1016/S1097-2765(00)80111-2 .
PMID
9702189 .
Wang J, Hoshino T, Redner RL, Kajigaya S, Liu JM (1998).
"ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex" . Proc. Natl. Acad. Sci. U.S.A . 95 (18): 10860–5.
Bibcode :
1998PNAS...9510860W .
doi :
10.1073/pnas.95.18.10860 .
PMC
27986 .
PMID
9724795 .
Ordentlich P, Downes M, Xie W, Genin A, Spinner NB, Evans RM (1999).
"Unique forms of human and mouse nuclear receptor corepressor SMRT" . Proc. Natl. Acad. Sci. U.S.A . 96 (6): 2639–44.
Bibcode :
1999PNAS...96.2639O .
doi :
10.1073/pnas.96.6.2639 .
PMC
15821 .
PMID
10077563 .
Dowell P, Ishmael JE, Avram D, Peterson VJ, Nevrivy DJ, Leid M (1999).
"Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein" . J. Biol. Chem . 274 (22): 15901–7.
doi :
10.1074/jbc.274.22.15901 .
PMID
10336495 .
Boutell JM, Thomas P, Neal JW, Weston VJ, Duce J, Harper PS, Jones AL (2000).
"Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin" . Hum. Mol. Genet . 8 (9): 1647–55.
doi :
10.1093/hmg/8.9.1647 .
PMID
10441327 .
Nagaya T, Chen KS, Fujieda M, Ohmori S, Richer JK, Horwitz KB, Lupski JR, Seo H (1999). "Localization of the human nuclear receptor corepressor (hN-CoR) gene between the CMT1A and the SMS critical regions of chromosome 17p11.2". Genomics . 59 (3): 339–41.
doi :
10.1006/geno.1998.5694 .
PMID
10444336 .
Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999).
"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 6 (3): 197–205.
doi :
10.1093/dnares/6.3.197 .
PMID
10470851 .
Hu X, Lazar MA (1999). "The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors". Nature . 402 (6757): 93–6.
Bibcode :
1999Natur.402...93H .
doi :
10.1038/47069 .
PMID
10573424 .
S2CID
4380362 .
Huang EY, Zhang J, Miska EA, Guenther MG, Kouzarides T, Lazar MA (2000).
"Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway" . Genes Dev . 14 (1): 45–54.
doi :
10.1101/gad.14.1.45 .
PMC
316335 .
PMID
10640275 .
Morohoshi F, Mitani S, Mitsuhashi N, Kitabayashi I, Takahashi E, Suzuki M, Munakata N, Ohki M (2000). "Structure and expression pattern of a human MTG8/ETO family gene, MTGR1". Gene . 241 (2): 287–95.
doi :
10.1016/S0378-1119(99)00481-3 .
PMID
10675041 .
Masselink H, Bernards R (2000).
"The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR" . Oncogene . 19 (12): 1538–46.
doi :
10.1038/sj.onc.1203421 .
PMID
10734313 .
References
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GRCh38: Ensembl release 89: ENSG00000141027 –
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^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
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"ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex" . Proc. Natl. Acad. Sci. U.S.A . 95 (18): 10860–5.
Bibcode :
1998PNAS...9510860W .
doi :
10.1073/pnas.95.18.10860 .
PMC
27986 .
PMID
9724795 .
^ Wang J, Hoshino T, Redner RL, Kajigaya S, Liu JM (1998).
"ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex" . Proc Natl Acad Sci USA . 95 (18): 10860–5.
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^
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"The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2" . Mol. Cell . 9 (3): 611–23.
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^
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d Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J (September 2003).
"N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso" . Mol. Cell . 12 (3): 723–34.
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^
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"Dissociation of steroid receptor coactivator 1 and nuclear receptor corepressor recruitment to the human glucocorticoid receptor by modification of the ligand-receptor interface: the role of tyrosine 735" . Mol. Endocrinol . 17 (5): 845–59.
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^ Laherty CD, Billin AN, Lavinsky RM, Yochum GS, Bush AC, Sun JM, Mullen TM, Davie JR, Rose DW, Glass CK, Rosenfeld MG, Ayer DE, Eisenman RN (July 1998).
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External links