From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
CREB regulated transcription coactivator 2 , also known as CRTC2 , is a
protein which in humans is encoded by the CRTC2
gene .
[5]
[6]
[7]
Function CRTC2, initially called TORC2, is a transcriptional
coactivator for the transcription factor
CREB and a central regulator of
gluconeogenic
gene expression in response to
cAMP .
[8] CRTC2 is thought to drive tumorigenesis in
STK11 (LKB1)-null non-small cell lung cancers (
NSCLC ).
[9]
Interactions CRTC2 has been shown to
interact with
SNF1LK2
[10] and
YWHAQ .
[10]
[11]
References
^
a b c
GRCh38: Ensembl release 89: ENSG00000160741 –
Ensembl , May 2017
^
a b c
GRCm38: Ensembl release 89: ENSMUSG00000027936 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Entrez Gene: CRTC2 CREB regulated transcription coactivator 2" .
^ Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, et al. (October 2003).
"Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells" . Proceedings of the National Academy of Sciences of the United States of America . 100 (21): 12147–52.
doi :
10.1073/pnas.1932773100 .
PMC
218727 .
PMID
14506290 .
^ Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (August 2003).
"TORCs: transducers of regulated CREB activity" . Molecular Cell . 12 (2): 413–23.
doi :
10.1016/j.molcel.2003.08.013 .
PMID
14536081 .
^ Cheng A, Saltiel AR (March 2006). "More TORC for the gluconeogenic engine". BioEssays . 28 (3): 231–4.
CiteSeerX
10.1.1.604.5745 .
doi :
10.1002/bies.20375 .
PMID
16479585 .
^ Rodón L, Svensson RU, Wiater E, Chun MG, Tsai WW, Eichner LJ, et al. (July 2019).
"The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non-small cell lung cancer" . Science Advances . 5 (7): eaaw6455.
Bibcode :
2019SciA....5.6455R .
doi :
10.1126/sciadv.aaw6455 .
PMC
6656544 .
PMID
31355336 . ^
a b Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, et al. (October 2004).
"The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector" . Cell . 119 (1): 61–74.
doi :
10.1016/j.cell.2004.09.015 .
PMID
15454081 .
S2CID
18616459 .
^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007).
"Large-scale mapping of human protein-protein interactions by mass spectrometry" . Molecular Systems Biology . 3 (1): 89.
doi :
10.1038/msb4100134 .
PMC
1847948 .
PMID
17353931 .
Further reading
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4.
doi :
10.1016/0378-1119(94)90802-8 .
PMID
8125298 . Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56.
doi :
10.1016/S0378-1119(97)00411-3 .
PMID
9373149 . Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, et al. (October 2003).
"Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells" . Proceedings of the National Academy of Sciences of the United States of America . 100 (21): 12147–52.
doi :
10.1073/pnas.1932773100 .
PMC
218727 .
PMID
14506290 . Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (August 2003).
"TORCs: transducers of regulated CREB activity" . Molecular Cell . 12 (2): 413–23.
doi :
10.1016/j.molcel.2003.08.013 .
PMID
14536081 . Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, et al. (August 2004).
"Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization" . Current Biology . 14 (16): 1436–50.
Bibcode :
2004CBio...14.1436J .
doi :
10.1016/j.cub.2004.07.051 .
PMID
15324660 .
S2CID
2371325 . Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, et al. (October 2004).
"The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector" . Cell . 119 (1): 61–74.
doi :
10.1016/j.cell.2004.09.015 .
PMID
15454081 .
S2CID
18616459 . Al-Hakim AK, Göransson O, Deak M, Toth R, Campbell DG, Morrice NA, et al. (December 2005). "14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK". Journal of Cell Science . 118 (Pt 23): 5661–73.
doi :
10.1242/jcs.02670 .
PMID
16306228 .
S2CID
17404931 . Siu YT, Chin KT, Siu KL, Yee Wai Choy E, Jeang KT, Jin DY (July 2006).
"TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats" . Journal of Virology . 80 (14): 7052–9.
doi :
10.1128/JVI.00103-06 .
PMC
1489057 .
PMID
16809310 . Wu Z, Huang X, Feng Y, Handschin C, Feng Y, Gullicksen PS, et al. (September 2006).
"Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells" . Proceedings of the National Academy of Sciences of the United States of America . 103 (39): 14379–84.
Bibcode :
2006PNAS..10314379W .
doi :
10.1073/pnas.0606714103 .
PMC
1569674 .
PMID
16980408 . Yang Q, Inoki K, Ikenoue T, Guan KL (October 2006).
"Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity" . Genes & Development . 20 (20): 2820–32.
doi :
10.1101/gad.1461206 .
PMC
1619946 .
PMID
17043309 . Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007).
"Large-scale mapping of human protein-protein interactions by mass spectrometry" . Molecular Systems Biology . 3 (1): 89.
doi :
10.1038/msb4100134 .
PMC
1847948 .
PMID
17353931 . Ravnskjaer K, Kester H, Liu Y, Zhang X, Lee D, Yates JR, Montminy M (June 2007).
"Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression" . The EMBO Journal . 26 (12): 2880–9.
doi :
10.1038/sj.emboj.7601715 .
PMC
1894761 .
PMID
17476304 . Kuraishy AI, French SW, Sherman M, Herling M, Jones D, Wall R, Teitell MA (June 2007).
"TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation" . Proceedings of the National Academy of Sciences of the United States of America . 104 (24): 10175–80.
Bibcode :
2007PNAS..10410175K .
doi :
10.1073/pnas.0704170104 .
PMC
1891214 .
PMID
17548807 .
External links
