From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Serine/threonine-protein kinase PRP4 homolog is an
enzyme that in humans is encoded by the PRPF4B
gene .
[5]
[6]
[7]
Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs).
[7]
Interactions
PRPF4B has been shown to
interact with
Pinin .
[8]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000112739 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000021413 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998).
"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro" . DNA Res . 5 (1): 31–9.
doi :
10.1093/dnares/5.1.31 .
PMID
9628581 .
^ Kojima T, Zama T, Wada K, Onogi H, Hagiwara M (Aug 2001).
"Cloning of human PRP4 reveals interaction with Clk1" . J Biol Chem . 276 (34): 32247–56.
doi :
10.1074/jbc.M103790200 .
PMID
11418604 .
^
a
b
"Entrez Gene: PRPF4B PRP4 pre-mRNA processing factor 4 homolog B (yeast)" .
^ Dellaire, Graham; Makarov Evgeny M; Cowger Jeff J M; Longman Dasa; Sutherland Heidi G E; Lührmann Reinhard; Torchia Joseph; Bickmore Wendy A (Jul 2002).
"Mammalian PRP4 Kinase Copurifies and Interacts with Components of Both the U5 snRNP and the N-CoR Deacetylase Complexes" . Mol. Cell. Biol . 22 (14). United States: 5141–56.
doi :
10.1128/MCB.22.14.5141-5156.2002 .
hdl :
11858/00-001M-0000-0029-BC76-A .
ISSN
0270-7306 .
PMC
139773 .
PMID
12077342 .
Further reading
Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ . 4 (10): 821–30.
PMID
8274451 .
Gross T, Lützelberger M, Weigmann H, et al. (1997).
"Functional analysis of the fission yeast Prp4 protein kinase involved in pre-mRNA splicing and isolation of a putative mammalian homologue" . Nucleic Acids Res . 25 (5): 1028–35.
doi :
10.1093/nar/25.5.1028 .
PMC
146536 .
PMID
9102632 .
Huang Y, Deng T, Winston BW (2000). "Characterization of hPRP4 kinase activation: potential role in signaling". Biochem. Biophys. Res. Commun . 271 (2): 456–63.
doi :
10.1006/bbrc.2000.2651 .
PMID
10799319 .
Jurica MS, Licklider LJ, Gygi SR, et al. (2002).
"Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis" . RNA . 8 (4): 426–39.
doi :
10.1017/S1355838202021088 .
PMC
1370266 .
PMID
11991638 .
Dellaire G, Makarov EM, Cowger JJ, et al. (2002).
"Mammalian PRP4 Kinase Copurifies and Interacts with Components of Both the U5 snRNP and the N-CoR Deacetylase Complexes" . Mol. Cell. Biol . 22 (14): 5141–56.
doi :
10.1128/MCB.22.14.5141-5156.2002 .
PMC
139773 .
PMID
12077342 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol . 22 (6): 707–16.
doi :
10.1038/nbt971 .
PMID
15146197 .
S2CID
27764390 .
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004).
"Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5.
Bibcode :
2004PNAS..10112130B .
doi :
10.1073/pnas.0404720101 .
PMC
514446 .
PMID
15302935 .
Bennett EM, Lever AM, Allen JF (2004).
"Human Immunodeficiency Virus Type 2 Gag Interacts Specifically with PRP4, a Serine-Threonine Kinase, and Inhibits Phosphorylation of Splicing Factor SF2" . J. Virol . 78 (20): 11303–12.
doi :
10.1128/JVI.78.20.11303-11312.2004 .
PMC
521795 .
PMID
15452250 .
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol . 23 (1): 94–101.
doi :
10.1038/nbt1046 .
PMID
15592455 .
S2CID
7200157 .
Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005).
"Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules" . Mol. Cell. Proteomics . 4 (9): 1240–50.
doi :
10.1074/mcp.M500089-MCP200 .
PMID
15951569 .
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell . 122 (6): 957–68.
doi :
10.1016/j.cell.2005.08.029 .
hdl :
11858/00-001M-0000-0010-8592-0 .
PMID
16169070 .
S2CID
8235923 .
Nousiainen M, Silljé HH, Sauer G, et al. (2006).
"Phosphoproteome analysis of the human mitotic spindle" . Proc. Natl. Acad. Sci. U.S.A . 103 (14): 5391–6.
Bibcode :
2006PNAS..103.5391N .
doi :
10.1073/pnas.0507066103 .
PMC
1459365 .
PMID
16565220 .
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol . 24 (10): 1285–92.
doi :
10.1038/nbt1240 .
PMID
16964243 .
S2CID
14294292 .
Olsen JV, Blagoev B, Gnad F, et al. (2006).
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48.
doi :
10.1016/j.cell.2006.09.026 .
PMID
17081983 .
S2CID
7827573 .
Ewing RM, Chu P, Elisma F, et al. (2007).
"Large-scale mapping of human protein–protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89.
doi :
10.1038/msb4100134 .
PMC
1847948 .
PMID
17353931 .
Huang B, Ahn YT, McPherson L, et al. (2007).
"Interaction of PRP4 with Krüppel-Like Factor 13 Regulates CCL5 Transcription" . J. Immunol . 178 (11): 7081–7.
doi :
10.4049/jimmunol.178.11.7081 .
PMC
2674583 .
PMID
17513757 .