From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
PRPF40A
Identifiers
Aliases
PRPF40A , FBP-11, FBP11, FLAF1, FNBP3, HIP-10, HIP10, HYPA, NY-REN-6, Prp40, pre-mRNA processing factor 40 homolog AExternal IDs
OMIM :
612941
MGI :
1860512
HomoloGene :
6377
GeneCards :
PRPF40A
Wikidata
Pre-mRNA-processing factor 40 homolog A is a
protein that in humans is encoded by the PRPF40A
gene .
[5]
[6]
[7]
Interactions
PRPF40A has been shown to
interact with
Huntingtin .
[8]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000196504 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000061136 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Bedford MT, Reed R, Leder P (September 1998).
"WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif" . Proc Natl Acad Sci U S A . 95 (18): 10602–7.
Bibcode :
1998PNAS...9510602B .
doi :
10.1073/pnas.95.18.10602 .
PMC
27941 .
PMID
9724750 .
^ Wiesner S, Stier G, Sattler M, Macias MJ (December 2002). "Solution structure and ligand recognition of the WW domain pair of the yeast splicing factor Prp40". J Mol Biol . 324 (4): 807–22.
doi :
10.1016/S0022-2836(02)01145-2 .
PMID
12460579 .
^
"Entrez Gene: PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)" .
^ Faber PW, Barnes G T, Srinidhi J, Chen J, Gusella J F, MacDonald M E (September 1998).
"Huntingtin interacts with a family of WW domain proteins" . Hum. Mol. Genet . 7 (9): 1463–74.
doi :
10.1093/hmg/7.9.1463 .
ISSN
0964-6906 .
PMID
9700202 .
Further reading
Chan DC, Bedford MT, Leder P (1996).
"Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains" . EMBO J . 15 (5): 1045–54.
doi :
10.1002/j.1460-2075.1996.tb00442.x .
PMC
450002 .
PMID
8605874 .
Bedford MT, Chan DC, Leder P (1997).
"FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands" . EMBO J . 16 (9): 2376–83.
doi :
10.1093/emboj/16.9.2376 .
PMC
1169838 .
PMID
9171351 .
Faber PW, Barnes GT, Srinidhi J, et al. (1998).
"Huntingtin interacts with a family of WW domain proteins" . Hum. Mol. Genet . 7 (9): 1463–74.
doi :
10.1093/hmg/7.9.1463 .
PMID
9700202 .
Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer . 83 (4): 456–64.
doi :
10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 .
PMID
10508479 .
S2CID
21839750 .
Bedford MT, Sarbassova D, Xu J, et al. (2000).
"A novel pro-Arg motif recognized by WW domains" . J. Biol. Chem . 275 (14): 10359–69.
doi :
10.1074/jbc.275.14.10359 .
PMID
10744724 .
Zhang QH, Ye M, Wu XY, et al. (2001).
"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells" . Genome Res . 10 (10): 1546–60.
doi :
10.1101/gr.140200 .
PMC
310934 .
PMID
11042152 .
Wenzel J, Sanzenbacher R, Ghadimi M, et al. (2002). "Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor". FEBS Lett . 509 (2): 255–62.
doi :
10.1016/S0014-5793(01)03174-X .
PMID
11741599 .
S2CID
33084576 .
Allen M, Friedler A, Schon O, Bycroft M (2002). "The structure of an FF domain from human HYPA/FBP11". J. Mol. Biol . 323 (3): 411–6.
doi :
10.1016/S0022-2836(02)00968-3 .
PMID
12381297 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Katoh M, Katoh M (2004). "Identification and characterization of human FNBP3 gene in silico". Int. J. Mol. Med . 12 (4): 651–6.
doi :
10.3892/ijmm.12.4.651 .
PMID
12964049 .
Busino L, Donzelli M, Chiesa M, et al. (2003). "Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage". Nature . 426 (6962): 87–91.
Bibcode :
2003Natur.426...87B .
doi :
10.1038/nature02082 .
PMID
14603323 .
S2CID
768783 .
Mizutani K, Suetsugu S, Takenawa T (2004). "FBP11 regulates nuclear localization of N-WASP and inhibits N-WASP-dependent microspike formation". Biochem. Biophys. Res. Commun . 313 (3): 468–74.
doi :
10.1016/j.bbrc.2003.11.139 .
PMID
14697212 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004).
"Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5.
Bibcode :
2004PNAS..10112130B .
doi :
10.1073/pnas.0404720101 .
PMC
514446 .
PMID
15302935 .
Jin J, Smith FD, Stark C, et al. (2004).
"Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization" . Curr. Biol . 14 (16): 1436–50.
Bibcode :
2004CBio...14.1436J .
doi :
10.1016/j.cub.2004.07.051 .
PMID
15324660 .
S2CID
2371325 .
Goehler H, Lalowski M, Stelzl U, et al. (2004).
"A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease" . Mol. Cell . 15 (6): 853–65.
doi :
10.1016/j.molcel.2004.09.016 .
PMID
15383276 .
Lin KT, Lu RM, Tarn WY (2004).
"The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo" . Mol. Cell. Biol . 24 (20): 9176–85.
doi :
10.1128/MCB.24.20.9176-9185.2004 .
PMC
517884 .
PMID
15456888 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
PDB gallery
1uzc : THE STRUCTURE OF AN FF DOMAIN FROM HUMAN HYPA/FBP11
1ywi : Structure of the FBP11WW1 domain complexed to the peptide APPTPPPLPP
1ywj : Structure of the FBP11WW1 domain
1zr7 : Solution structure of the first WW domain of FBP11
2cqn : Solution structure of the FF domain of human Formin-binding protein 3
2dyf : Solution structure of the first WW domain of FBP11 / HYPA (FBP11 WW1) complexed with a PL (PPLP) motif peptide ligand