From Wikipedia, the free encyclopedia
Protein found in humans
mRNA-decapping enzyme 1A is a
protein that in humans is encoded by the DCP1A
gene .
[5]
Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway.
[5]
Interactions
DCP1A has been shown to
interact with
DCP2
[6] and
UPF1 .
[6] It has also been shown to colocalize with
GW182 , and other markers of
P-body .
[7] Human DCP1A is heterotrimeric,
[8] and makes contacts with the scaffold EDC3/4.
[9] The
Arabidopsis thaliana homolog interacts with the plant specific type XI
myosin motor protein.
[10]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000272886 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000021962 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b
"Entrez Gene: DCP1A DCP1 decapping enzyme homolog A (S. cerevisiae)" .
^
a
b Lykke-Andersen J (December 2002).
"Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay" . Molecular and Cellular Biology . 22 (23): 8114–8121.
doi :
10.1128/MCB.22.23.8114-8121.2002 .
PMC
134073 .
PMID
12417715 .
^ Eystathioy T, Jakymiw A, Chan EK, Séraphin B, Cougot N, Fritzler MJ (October 2003).
"The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies" . RNA . 9 (10): 1171–1173.
doi :
10.1261/rna.5810203 .
PMC
1370480 .
PMID
13130130 .
^ Tritschler F, Braun JE, Motz C, Igreja C, Haas G, Truffault V, et al. (December 2009).
"DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa" . Proceedings of the National Academy of Sciences of the United States of America . 106 (51): 21591–21596.
Bibcode :
2009PNAS..10621591T .
doi :
10.1073/pnas.0909871106 .
PMC
2789166 .
PMID
19966221 .
^ Tritschler F, Eulalio A, Truffault V, Hartmann MD, Helms S, Schmidt S, et al. (December 2007).
"A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting" . Molecular and Cellular Biology . 27 (24): 8600–8611.
doi :
10.1128/MCB.01506-07 .
PMC
2169425 .
PMID
17923697 .
^ Steffens A, Jaegle B, Tresch A, Hülskamp M, Jakoby M (April 2014).
"Processing-body movement in Arabidopsis depends on an interaction between myosins and DECAPPING PROTEIN1" . Plant Physiology . 164 (4): 1879–1892.
doi :
10.1104/pp.113.233031 .
PMC
3982750 .
PMID
24525673 .
Further reading
Bai RY, Koester C, Ouyang T, Hahn SA, Hammerschmidt M, Peschel C, Duyster J (March 2002). "SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling". Nature Cell Biology . 4 (3): 181–190.
doi :
10.1038/ncb753 .
PMID
11836524 .
S2CID
19938060 .
Callebaut I (May 2002).
"An EVH1/WH1 domain as a key actor in TGFbeta signalling" . FEBS Letters . 519 (1–3): 178–180.
doi :
10.1016/S0014-5793(02)02751-5 .
PMID
12023040 .
S2CID
84499961 .
Lykke-Andersen J (December 2002).
"Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay" . Molecular and Cellular Biology . 22 (23): 8114–8121.
doi :
10.1128/MCB.22.23.8114-8121.2002 .
PMC
134073 .
PMID
12417715 .
Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T (December 2002).
"The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci" . RNA . 8 (12): 1489–1501.
doi :
10.1017/S1355838202021726 .
PMC
1370355 .
PMID
12515382 .
Leonard D, Ajuh P, Lamond AI, Legerski RJ (September 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochemical and Biophysical Research Communications . 308 (4): 793–801.
CiteSeerX
10.1.1.539.8359 .
doi :
10.1016/S0006-291X(03)01486-4 .
PMID
12927788 .
Lehner B, Sanderson CM (July 2004).
"A protein interaction framework for human mRNA degradation" . Genome Research . 14 (7): 1315–1323.
doi :
10.1101/gr.2122004 .
PMC
442147 .
PMID
15231747 .
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004).
"Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proceedings of the National Academy of Sciences of the United States of America . 101 (33): 12130–12135.
Bibcode :
2004PNAS..10112130B .
doi :
10.1073/pnas.0404720101 .
PMC
514446 .
PMID
15302935 .
Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R (July 2005).
"MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies" . Nature Cell Biology . 7 (7): 719–723.
doi :
10.1038/ncb1274 .
PMC
1855297 .
PMID
15937477 .
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–1178.
Bibcode :
2005Natur.437.1173R .
doi :
10.1038/nature04209 .
PMID
16189514 .
S2CID
4427026 .
Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J (December 2005).
"Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping" . Molecular Cell . 20 (6): 905–915.
doi :
10.1016/j.molcel.2005.10.031 .
PMID
16364915 .
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006).
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–648.
doi :
10.1016/j.cell.2006.09.026 .
PMID
17081983 .
S2CID
7827573 .