Sir John Anthony Hardy
FRS
[1] (born 9 November 1954)[
citation needed] is a human
geneticist and
molecular biologist at the
Reta Lila Weston Institute of Neurological Studies at
University College London with research interests in
neurological diseases.
[3]
[4]
[5]
[6]
Education
Hardy attended
St Ambrose College in the late 1960s, where his interest in biochemistry was encouraged by his Biology teacher, Mrs Cox.
[7] He received his Bachelor of Science degree from the
University of Leeds in 1976
[8] and his PhD from
Imperial College London in 1981
[8] for research on
dopamine and
amino acid
neuropharmacology.
Career and research
Following his PhD, Hardy did
postdoctoral research at the MRC Neuropathogenesis Unit in
Newcastle upon Tyne, England and then further postdoctoral work at the Swedish Brain Bank in
Umeå, Sweden where he started to work on
Alzheimer's disease.
[8]
He became Assistant Professor of Biochemistry at
St. Mary's Hospital,
Imperial College London in 1985 and initiated genetic studies of Alzheimer's disease there.
[9] He became Associate Professor in 1989 and then took the Pfeiffer Endowed Chair of Alzheimer's Research at the
University of South Florida, in
Tampa in 1992. In 1996 he moved to
Mayo Clinic in
Jacksonville, Florida, as Consultant and Professor of
Neuroscience.
He became Chair of Neuroscience in 2000 and moved to
National Institute on Aging, Bethesda, Maryland, as Chief of the Laboratory of Neurogenetics in 2001. In 2007 he took up the Chair of Molecular Biology of Neurological Disease at the
Reta Lila Weston Institute of Neurological Studies,
University College London.
On 29 November 2015, he was awarded the
Breakthrough Prize.
In 2018, Hardy, along with
Christian Haass,
Bart De Strooper and
Michel Goedert, received the
Brain Prize for "groundbreaking research on the genetic and molecular basis of Alzheimer's disease."
[10]
Awards and honours
Among other awards and honours, Hardy has won the
Breakthrough Prize in Life Sciences for dissecting the causes of
Alzheimer's disease,
Parkinson's disease and frontotemporal dementia; the
MetLife prize for research into Alzheimer's disease, and the
Potamkin Prize for his work in describing the first
genetic mutations in the amyloid gene in Alzheimer's disease, in 1991. He was elected a
Fellow of the Royal Society (FRS) in 2009.
[1] He was
knighted in the
2022 New Year Honours for services to "human health in improving our understanding of dementia and neurodegenerative diseases".
[11]
References
- ^
a
b
c
d
"Professor John Hardy FMedSci FRS". London:
Royal Society. Archived from
the original on 17 November 2015.
- ^
a
b
"Professor John Hardy FRS FMedSci". Archived from
the original on 2 August 2016. Retrieved 27 November 2015.
-
^
"HARDY, Prof. John".
Who's Who. Vol. 2015 (online
Oxford University Press ed.). A & C Black. (Subscription or
UK public library membership required.)
-
^ Hutton, Mike; Heutink, Peter; Lendon, Corinne L.; Rizzu, Patrizia; Baker, Matt; Froelich, Susanne; Houlden, Henry; Pickering-Brown, Stuart; Chakraverty, Sumi; Isaacs, Adrian; Grover, Andrew; Hackett, Jennifer; Adamson, Jennifer; Lincoln, Sarah; Dickson, Dennis; Davies, Peter; Petersen, Ronald C.; Stevens, Martijn; de Graaff, Esther; Wauters, Erwin; van Baren, Jeltje; Hillebrand, Marcel; Joosse, Marijke; Kwon, Jennifer M.; Nowotny, Petra; Che, Lien Kuei; Norton, Joanne; Morris, John C.; Reed, Lee A.; Trojanowski, John; Basun, Hans; Lannfelt, Lars; Neystat, Michael; Fahn, Stanley; Dark, Francis; Tannenberg, Tony; Dodd, Peter R.; Hayward, Nick; Kwok, John B. J.; Schofield, Peter R.; Andreadis, Athena; Snowden, Julie; Craufurd, David; Neary, David; Owen, Frank; Oostra, Ben A.; Hardy, John; Goate, Alison; van Swieten, John; Mann, David; Lynch, Timothy (1998). "Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17". Nature. 393 (6686): 702–705.
Bibcode:
1998Natur.393..702H.
doi:
10.1038/31508.
ISSN
0028-0836.
PMID
9641683.
S2CID
205001265.
-
^ Goate, Alison; Chartier-Harlin, Marie-Christine; Mullan, Mike; Brown, Jeremy; Crawford, Fiona; Fidani, Liana; Giuffra, Luis; Haynes, Andrew; Irving, Nick; James, Louise; Mant, Rebecca; Newton, Phillippa; Rooke, Karen; Roques, Penelope; Talbot, Chris; Pericak-Vance, Margaret; Roses, Alien; Williamson, Robert;
Rossor, Martin; Owen, Mike; Hardy, John (1991). "Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease". Nature. 349 (6311): 704–706.
Bibcode:
1991Natur.349..704G.
doi:
10.1038/349704a0.
ISSN
0028-0836.
PMID
1671712.
S2CID
4336069.
-
^ Hardy, J. (2002). "The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics". Science. 297 (5580): 353–356.
Bibcode:
2002Sci...297..353H.
doi:
10.1126/science.1072994.
ISSN
0036-8075.
PMID
12130773.
S2CID
15150253.
-
^ Keegan (7 January 2022).
"Old Boys News - New Year's Honours 2022". Saint Ambrose College Weekly News Bulletin. p. 6. Retrieved 11 January 2022.
- ^
a
b
c
Neuroscience NIH
Archived 10 December 2015 at the
Wayback Machine
-
^
HIH.gov
Archived 5 November 2011 at the
Wayback Machine
-
^
thebrainprize.org
-
^
"No. 63571".
The London Gazette (Supplement). 1 January 2022. p. N2.
-
^ Devlin, Hannah (6 March 2018).
"Brain prize winner calls Brexit a 'disaster' for the NHS and science". The Guardian. Retrieved 2 May 2018.
-
^
"John Hardy". Leeds University. July 2017. Retrieved 13 July 2017.
-
^
https://breakthroughprize.org/ Breakthrough Prize 2016
-
^
"The EMBO Pocket Directory" (PDF). European Molecular Biology Organization. Archived from
the original on 16 March 2015.
-
^
"EMBO announces new members for 2015". Heidelberg:
European Molecular Biology Organization. Archived from
the original on 21 March 2016. Retrieved 8 November 2015.
-
^
Pritzker, MJ Fox Award for Parkinson Research
-
^
"Dan David Prize: LAUREATES 2014: Combatting Memory Loss, JOHN A. HARDY".
-
^
"MetLife Foundation Awards for Medical Research in Alzheimer's Disease" (PDF). Archived from
the original (PDF) on 13 October 2018.
|
---|
Mathematics | |
---|
Fundamental physics |
-
Nima Arkani-Hamed,
Alan Guth,
Alexei Kitaev,
Maxim Kontsevich,
Andrei Linde,
Juan Maldacena,
Nathan Seiberg,
Ashoke Sen,
Edward Witten (2012)
- Special:
Stephen Hawking,
Peter Jenni,
Fabiola Gianotti (ATLAS),
Michel Della Negra,
Tejinder Virdee,
Guido Tonelli,
Joseph Incandela (CMS) and
Lyn Evans (LHC) (2013)
-
Alexander Polyakov (2013)
-
Michael Green and
John Henry Schwarz (2014)
-
Saul Perlmutter and members of the
Supernova Cosmology Project;
Brian Schmidt,
Adam Riess and members of the
High-Z Supernova Team (2015)
- Special:
Ronald Drever,
Kip Thorne,
Rainer Weiss and contributors to
LIGO project (2016)
-
Yifang Wang,
Kam-Biu Luk and the
Daya Bay team,
Atsuto Suzuki and the
KamLAND team,
Kōichirō Nishikawa and the
K2K /
T2K team,
Arthur B. McDonald and the
Sudbury Neutrino Observatory team,
Takaaki Kajita and
Yōichirō Suzuki and the
Super-Kamiokande team (2016)
-
Joseph Polchinski,
Andrew Strominger,
Cumrun Vafa (2017)
-
Charles L. Bennett,
Gary Hinshaw,
Norman Jarosik,
Lyman Page Jr.,
David Spergel (2018)
- Special:
Jocelyn Bell Burnell (2018)
-
Charles Kane and
Eugene Mele (2019)
- Special:
Sergio Ferrara,
Daniel Z. Freedman,
Peter van Nieuwenhuizen (2019)
-
The Event Horizon Telescope Collaboration (2020)
-
Eric Adelberger,
Jens H. Gundlach and
Blayne Heckel (2021)
- Special:
Steven Weinberg (2021)
-
Hidetoshi Katori and
Jun Ye (2022)
-
Charles H. Bennett,
Gilles Brassard,
David Deutsch,
Peter W. Shor (2023)
-
John Cardy and
Alexander Zamolodchikov (2024)
|
---|
Life sciences |
-
Cornelia Bargmann,
David Botstein,
Lewis C. Cantley,
Hans Clevers,
Titia de Lange,
Napoleone Ferrara,
Eric Lander,
Charles Sawyers,
Robert Weinberg,
Shinya Yamanaka and
Bert Vogelstein (2013)
-
James P. Allison,
Mahlon DeLong,
Michael N. Hall,
Robert S. Langer,
Richard P. Lifton and
Alexander Varshavsky (2014)
-
Alim Louis Benabid,
Charles David Allis,
Victor Ambros,
Gary Ruvkun,
Jennifer Doudna and
Emmanuelle Charpentier (2015)
-
Edward Boyden,
Karl Deisseroth,
John Hardy,
Helen Hobbs and
Svante Pääbo (2016)
-
Stephen J. Elledge,
Harry F. Noller,
Roeland Nusse,
Yoshinori Ohsumi,
Huda Zoghbi (2017)
-
Joanne Chory,
Peter Walter,
Kazutoshi Mori,
Kim Nasmyth,
Don W. Cleveland (2018)
-
C. Frank Bennett and
Adrian R. Krainer,
Angelika Amon,
Xiaowei Zhuang,
Zhijian Chen (2019)
-
Jeffrey M. Friedman,
Franz-Ulrich Hartl,
Arthur L. Horwich,
David Julius,
Virginia Man-Yee Lee (2020)
-
David Baker,
Catherine Dulac,
Dennis Lo,
Richard J. Youle [
de] (2021)
-
Jeffery W. Kelly,
Katalin Karikó,
Drew Weissman,
Shankar Balasubramanian,
David Klenerman and
Pascal Mayer (2022)
-
Clifford P. Brangwynne,
Anthony A. Hyman,
Demis Hassabis,
John Jumper,
Emmanuel Mignot,
Masashi Yanagisawa (2023)
-
Carl June,
Michel Sadelain,
Sabine Hadida,
Paul Negulescu,
Fredrick Van Goor,
Thomas Gasser,
Ellen Sidransky and
Andrew Singleton (2024)
|
---|
|
---|
International | |
---|
National | |
---|
Academics | |
---|