From Wikipedia, the free encyclopedia
American physician-scientist (born 1959)
Charles L. Sawyers (born 1959) is a
Howard Hughes Medical Institute (HHMI) investigator who holds the
Marie-Josée and
Henry R. Kravis
Chair of the Human
Oncology and
Pathogenesis Program (HOPP) at
Memorial Sloan Kettering Cancer Center (MSK). HOPP is a program created in 2006 that comprises researchers from many disciplines to bridge clinical and laboratory discoveries.
[2]
Career
Sawyers received a BA from
Princeton University in 1981 and an MD from
Johns Hopkins University School of Medicine in 1985,
[3] followed by an internal medicine residency at the
University of California, San Francisco .
[4] He became a HHMI investigator in 2002 while working at UCLA's
Jonsson Cancer Center .
[5]
Sawyers works on molecularly targeted cancer drugs, with a focus on developing a new generation of treatment options for patients. He shared the 2009
Lasker-DeBakey Clinical Medical Research Award with
Brian J. Druker and
Nicholas Lydon ,
[6] for the development of the ABL kinase inhibitor
imatinib for patients with
chronic myeloid leukemia and the second-generation ABL inhibitor
dasatinib to overcome imatinib resistance. He also co-discovered the antiandrogen drugs
enzalutamide , approved by the
FDA in 2012, and
apalutamide
[7] approved in 2019, both for treatment of advanced
prostate cancer .
[8]
Sawyers' cancer research is discussed in the second episode of
Cancer: The Emperor of All Maladies .
Significant positions
Sawyers served as president of the
American Society for Clinical Investigation (ASCI) in 2007
[9] and of the American Association for Cancer Research (AACR) in 2012.
[10] He was also appointed to the National Cancer Advisory Board by President Obama in 2012,
[11] and has served on the Board of Directors of
Novartis since 2013.
[12]
He was a founding co-
editor of the
Annual Review of Cancer Biology in 2017,
[13] serving until 2021.
[14]
Memberships
Awards
References
^ Howard Hughes Medical Institute,
Annual Scientific Report , The Institute, 1990, p. 507.
^
"At Work: Human Oncology and Pathogenesis Program Chair Charles Sawyers | Memorial Sloan Kettering Cancer Center" . www.mskcc.org . Retrieved 5 April 2017 .
^
"Susan Schneck Weds Charles Sawyers" . The New York Times . 22 October 1990. Retrieved 3 March 2017 .
^
"UCSF Department of Medicine Alumni Profile: Dr. Charles Sawyers" . medicine.ucsf.edu . Archived from
the original on 8 September 2015. Retrieved 3 March 2017 .
^
"Charles L. Sawyers, MD" . HHMI.org . Retrieved 5 April 2017 .
^ Grindlinger, Brooke; Chao, ES (1 October 2009).
"Trio receives Lasker Foundation Clinical Award for breakthroughs in leukemia treatment" . Journal of Clinical Investigation . 119 (10): 2863–2865.
doi :
10.1172/JCI41141 .
ISSN
0021-9738 .
PMC
2752112 .
^ Tran C, Ouk S, Clegg NJ, Chen Y, Watson PA, Arora V, Wongvipat J, Smith-Jones PM, Yoo D, Kwon A, Wasielewska T, Welsbie D, Chen CD, Higano CS, Beer TM, Hung DT, Scher HI, Jung ME, Sawyers CL (2009).
"Development of a second-generation antiandrogen for treatment of advanced prostate cancer" . Science . 324 (5928): 787–90.
Bibcode :
2009Sci...324..787T .
doi :
10.1126/science.1168175 .
PMC
2981508 .
PMID
19359544 .
^ Reyes, Antonio A.; Akeson, Richard (1988). "Generation of Multiple Independent Substitution Mutants by M13 in Vitro Mutagenesis Using a Single Mutagenic Oligonucleotide". DNA . 7 (8): 579–584.
doi :
10.1089/dna.1.1988.7.579 .
PMID
3180999 .
^
"2008 American Society for Clinical Investigation Presidential Address" (PDF) . the-asci.org . Retrieved 3 March 2017 .
^
"Charles L. Sawyers, MD" . aacr.org . Retrieved 4 March 2017 .
^
"President Obama Announces More Key Administration Posts" . whitehouse.gov . 6 December 2012. Retrieved 4 March 2017 .
^
"Charles L. Sawyers, M.D. Member of the Board of Directors" (PDF) . novartis.com . Retrieved 4 March 2017 .
^ Jacks, Tyler; Sawyers, Charles (2017).
"Introduction" . Annual Review of Cancer Biology . 1 : i.
doi :
10.1146/annurev-ca-01-121516-100001 .
^
"Annual Review of Cancer Biology Editorial Committee" . Annual Reviews . 2022. Retrieved 18 July 2022 .
^
"Doris Duke Charitable Foundation Awards $10.5 Million for Medical Research" . Philanthropy News Digest (PND) . Retrieved 5 April 2017 .
^
"Recipients of the David A. Karnofsky Memorial Award and Lecture - The ASCO Post" . www.ascopost.com . Archived from
the original on 19 September 2017. Retrieved 5 April 2017 .
^
"Awards, Appointments, Announcements" . JNCI Journal of the National Cancer Institute . 97 (11): 797. 1 June 2005.
doi :
10.1093/jnci/97.11.797 .
^
"Dorothy P. Landon-AACR Prize for Translational Cancer Research" . www.aacr.org . Archived from
the original on 3 September 2017. Retrieved 5 April 2017 .
^ Foundation, Lasker.
"Molecularly targeted treatments for chronic myeloid leukemia | The Lasker Foundation" . The Lasker Foundation . Retrieved 5 April 2017 .
^
"Breakthrough Prize" . breakthroughprize.org . Retrieved 5 April 2017 .
^
"Taubman Prize" . A. Alfred Taubman Medical Research Institute . Retrieved 16 March 2017 .
^
"2014 Honorees" . The Hope Funds for Cancer Research . 5 September 2013. Retrieved 5 April 2017 .
^
"BBVA Foundation Frontiers of Knowledge Awards" . www.fbbva.es . Archived from
the original on 21 September 2015. Retrieved 5 April 2017 .
External links
Memorial Sloan Kettering Cancer Center - Biography, Lab Description
Human Oncology and Pathogenesis Program
Howard Hughes Medical Institute - Biography, Lab Description
Video:
Talk by Sawyers at the NIH-Lasker Clinical Research Scholars Symposium, March 31, 2011.
Video:
Speaking to Katie Couric regarding Stand Up 2 Cancer - @KatieCouric, CBS news, September 8, 2010
Quoted:
New Drugs Stir Debate on Rules of Clinical Trials, New York Times, September 19, 2010
Quoted:
What can we learn from curable cancers? Newsweek, September 7, 2010
Video:
Speaking with Charlie Rose: A discussion about Cancer Treatments, October 1, 2009
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Stephen Hawking ,
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Guido Tonelli ,
Joseph Incandela (CMS) and
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Yifang Wang ,
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Life sciences
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